|
| Status |
Public on Jan 31, 2011 |
| Title |
Global Reactivation of Epigenetically Silenced Genes in Prostate Cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional silencing associated with aberrant promoter hypermethylation is a common mechanism of inactivation of tumor suppressor genes in cancer cells.
|
| |
|
| Overall design |
To profile the genes silenced by hypermethylation in prostate cancer, we screened an expression microarray for genes reactivated in the LNCaP, DU-145, PC-3 and MDA2b prostate tumor cell lines after treatment with the demethylating drug 5-aza-2 deoxycytidine (5Aza-dC) and histone deacetylation inhibiting drug trichostatin A (TSA).
|
| |
|
| Contributor(s) |
Ochs MF |
| Citation(s) |
20699414 |
| |
| Submission date |
Oct 15, 2009 |
| Last update date |
Mar 21, 2012 |
| Contact name |
Ilsiya Ibragimova |
| E-mail(s) |
[email protected]
|
| Organization name |
Fox Chase Cancer Center
|
| Department |
ICR
|
| Lab |
Paul Cairns
|
| Street address |
333 Cottman ave, w350
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19111 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9452 |
MWG human 15k oligonucleotide microarray |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA120275 |
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