|
| Status |
Public on Jul 01, 2010 |
| Title |
Control of intestinal homeostasis, colitis and colitis-associated colorectal cancer by the inflammatory caspases |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Inflammatory caspases are essential effectors of inflammation and cell death. Here, we investigated their roles in colitis and colorectal cancer and report a bimodal regulation of intestinal homeostasis, inflammation and tumorigenesis by caspases-1 and -12. Casp1-/- mice exhibited defects in mucosal tissue repair and succumbed rapidly after dextran sulfate sodium (DSS) administration. This phenotype was rescued by administration of exogenous interleukin-18 and was partially reproduced in mice deficient in the inflammasome adaptor ASC. Casp12-/- mice, in which the inflammasome is derepressed, were resistant to acute colitis and showed signs of enhanced repair. Together with their increased inflammatory response, the enhanced repair response of Casp12-/- mice rendered them more susceptible to colorectal cancer induced by azoxymethane (AOM)+DSS. Taken together, our results indicate that the inflammatory caspases are critical in the induction of inflammation in the gut following injury, which is necessary for tissue repair and maintenance of immune tolerance.
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| |
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| Overall design |
Total RNA obtained from isolated tumors or normal colon tissue from wild type and caspase-12 deficient mice were compared.
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| Contributor(s) |
Yeretssian G, Saleh M |
| Citation(s) |
20226691 |
| |
| Submission date |
Feb 18, 2010 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Garabet Yeretssian |
| Organization name |
McGill
|
| Department |
Medicine
|
| Lab |
Saleh
|
| Street address |
3649 Promenade Sir-William Osler
|
| City |
Montreal |
| State/province |
QC |
| ZIP/Postal code |
H3G 0B1 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA125543 |
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