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| Status |
Public on Sep 29, 2022 |
| Title |
Aberrant lncRNA–mRNA Expression Profile and Function Networks during the Adipogenesis of Mesenchymal Stem Cells from Patients with Ankylosing Spondylitis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We have already demonstrated that mesenchymal stem cells from patients with ankylosing spondylitis (ASMSCs) exhibited greater adipogenic differentiation potential than those from healthy donors (HDMSCs). Here, we further investigated the expression profile of long noncoding RNA (lncRNA) and mRNA, aiming to explore the underlying mechanism of abnormal adipogenic differentiation in ASMSCs.
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| Overall design |
HDMSCs and ASMSCs were separately isolated and induced with adipogenic differentiation medium for 10 days. Thereafter, lncRNAs and mRNAs that were differentially expressed (DE) between HDMSCs and ASMSCs were identified via high-throughput sequencing
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| Contributor(s) |
Liu Z, Cen S, Qiu S, Cai M |
| Citation(s) |
36246583 |
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| Submission date |
Sep 02, 2022 |
| Last update date |
Oct 28, 2022 |
| Contact name |
Zhenhua Liu |
| Organization name |
Zhujiang Hospital
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| Department |
Spine surgery
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| Lab |
orthopedic center
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| Street address |
industry Avenue 253#
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| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510128 |
| Country |
China |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (6)
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| GSM6541539 |
Mesenchymal stem cell, ankylosing spondylitis patient 1,induction day 10 |
| GSM6541540 |
Mesenchymal stem cell, ankylosing spondylitis patient 2,induction day 10 |
| GSM6541541 |
Mesenchymal stem cell, ankylosing spondylitis patient 3,induction day 10 |
| GSM6541542 |
Mesenchymal stem cell, healthy donor 1,induction day 10 |
| GSM6541543 |
Mesenchymal stem cell, healthy donor 2,induction day 10 |
| GSM6541544 |
Mesenchymal stem cell, healthy donor 3,induction day 10 |
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| Relations |
| BioProject |
PRJNA876263 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE212613_H1H2H3--A2A3A4.all.gene.xls.gz |
2.1 Mb |
(ftp)(http) |
XLS |
| GSE212613_H1H2H3--A2A3A4.all.mRNA.xls.gz |
3.2 Mb |
(ftp)(http) |
XLS |
| GSE212613_H1H2H3--A2A3A4.all.ncRNA.xls.gz |
849.0 Kb |
(ftp)(http) |
XLS |
| GSE212613_H1H2H3--A2A3A4.different.gene.xls.gz |
70.8 Kb |
(ftp)(http) |
XLS |
| GSE212613_H1H2H3--A2A3A4.different.mRNA.xls.gz |
112.4 Kb |
(ftp)(http) |
XLS |
| GSE212613_H1H2H3--A2A3A4.different.ncRNA.xls.gz |
22.1 Kb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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