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| Status |
Public on Feb 13, 2023 |
| Title |
S-adenosylmethionine synthases specify distinct H3K3me3 populations and gene expression patterns during heat stress [RNA-seq: sams-4 RNAi, Heat shock] |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We find that two SAM synthases in C. elegans, SAMS-1 and SAMS-3/4, contribute differently to modification of H3K4me3, gene expression and survival in the heat stress response. Our data showing differential SAM provisioning to distinct groups of methylated targets based on SAM synthase source suggests that determining how methyl donors are provided will broaden insight into 1CC functions in aging and stress.
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| |
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| Overall design |
Examination of differential gene expression in C. elegans with low SAM at with and without heat shock
|
| Web link |
https://pubmed.ncbi.nlm.nih.gov/36756948/
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| |
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| Contributor(s) |
Godbole A, Walker A |
| Citation(s) |
36756948 |
| |
| Submission date |
Jan 24, 2023 |
| Last update date |
Feb 13, 2023 |
| Contact name |
Amy K Walker |
| E-mail(s) |
[email protected]
|
| Organization name |
UMass Chan Medical School
|
| Department |
Program in Molecular Medicine
|
| Lab |
Amy Walker
|
| Street address |
Suite 137, Biotech 2, 373 Plantation St
|
| City |
Worcester |
| State/province |
Massachusetts |
| ZIP/Postal code |
01605 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL13657 |
Illumina HiSeq 2000 (Caenorhabditis elegans) |
|
| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE223597 |
S-adenosylmethionine synthases specify distinct H3K3me3 populations and gene expression patterns during heat stress |
|
| Relations |
| BioProject |
PRJNA926941 |
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