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| Status |
Public on Jan 22, 2024 |
| Title |
Enhancement of the anticancer ability of natural killer cells through allogeneic mitochondrial transfer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Conventional natural killer (NK)-based anticancer immunotherapy has a limitation in that a culture period of approximately 2 weeks is required to increase the number and activity of NK cells. In addition, the anticancer activity of NK cells is closely associated with their mitochondrial function. In this study, we aimed to investigate whether the NK-anticancer activity increased after transferring allogeneic mitochondria into NK cells. Using this method, NK cells with enhanced anticancer activity can be produced without in vitro culture and can be used for anticancer treatment.
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| Overall design |
Total RNA from NK-92MI cells was isolated and hybridized on Affymetrix microarrays. The isolated mitochondria were transferred to the NK cells and compared to control NK cells.
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| Contributor(s) |
Kim SH, Kim MJ, Lim M, Kim J, Kim H, Yun C, Yoo Y, Lee Y, Min K, Choi Y |
| Citation(s) |
37370835 |
| |
| Submission date |
Jan 31, 2023 |
| Last update date |
Jan 23, 2024 |
| Contact name |
Jihye Kim |
| E-mail(s) |
[email protected]
|
| Phone |
7209755448
|
| Organization name |
Cleveland Clinic
|
| Street address |
9500 Euclid Ave.
|
| City |
Cleveland |
| State/province |
Ohio |
| ZIP/Postal code |
44195 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19251 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA930031 |
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