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| Status |
Public on Feb 22, 2024 |
| Title |
Effect of ezetimibe treatment on gene expression of TGFβ1-activated primary human lung fibroblasts |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To verify whether ezetimibe inhibits myofibroblast differentiation at the transcriptome level and to reveal the mechanism of action of ezetimibe, we sequenced primary human lung fibroblasts that we isolated and cultured.
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| Overall design |
Comparative gene expression analysis of mRNA-Seq data from primary human lung fibroblasts treated with TGFβ1 and/or ezetimibe (Negative control/ TGFβ1-treated positive control / TGFβ1&ezetimibe-treated group).
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| Contributor(s) |
Lee C, Kwak S, Han J, Shin J, Lee Y, Park J, Lim B, Lee J, Kim Y, Kim S, Bae S |
| Citation(s) |
38359963 |
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| Submission date |
Feb 23, 2023 |
| Last update date |
Feb 22, 2024 |
| Contact name |
Chanho Lee |
| E-mail(s) |
[email protected]
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| Organization name |
Yonsei University College of Medicine
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| Department |
Department of Internal Medicine
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| Street address |
50-1 Yonsei-ro
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| City |
Seodaemun-gu |
| State/province |
Seoul |
| ZIP/Postal code |
03722 |
| Country |
South Korea |
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| Platforms (1) |
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| Samples (9)
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| GSM7061235 |
Primary Lung fibroblast, Negative control, biol rep 1 |
| GSM7061236 |
Primary Lung fibroblast, Negative control, biol rep 2 |
| GSM7061237 |
Primary Lung fibroblast, Negative control, biol rep 3 |
| GSM7061238 |
Primary Lung fibroblast, ezetimibe treated, biol rep 1 |
| GSM7061239 |
Primary Lung fibroblast, ezetimibe treated, biol rep 2 |
| GSM7061240 |
Primary Lung fibroblast, ezetimibe treated, biol rep 3 |
| GSM7061241 |
Primary Lung fibroblast, Positive control, biol rep 1 |
| GSM7061242 |
Primary Lung fibroblast, Positive control, biol rep 2 |
| GSM7061243 |
Primary Lung fibroblast, Positive control, biol rep 3 |
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| Relations |
| BioProject |
PRJNA938140 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE225982_CountMatrix_transcript.txt.gz |
5.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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