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| Status |
Public on Nov 15, 2023 |
| Title |
Microarray expression analysis depicting MHCII-dependent features of FOXP3-expressing CD4 T regulatory cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis comparing K14 and MCHII+/- Tregs. The hypothesis was that the lack of MHCII+/- in the spleen and intestine would result in a large shift in K14 Treg gene expression away from an activated and effector phenotype. Results demonstrate how a lack of MHCII-antigen presentation in the small intestine, where Tregs exhibit an effector penotype, does not greatly reduce effector features of T regulatory cells in K14 mice.
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| Overall design |
RNA was isolated from splenic and intestinal FOXP3 Tregs and conventional T cells from control MHCII+/-, FOXP3GFP mice and experimental K14Aβb, FOXP3GFP mice which lack expression of MHCII outside of the thymus. Mice were pooled for each condition.
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| |
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| Contributor(s) |
Korn LL, Beiting D, Laufer TM |
| Citation(s) |
36935092 |
| |
| Submission date |
Feb 27, 2023 |
| Last update date |
Feb 14, 2024 |
| Contact name |
Terri Laufer |
| E-mail(s) |
[email protected]
|
| Phone |
(215)573-2955
|
| Organization name |
University of Pennsylvania
|
| Lab |
276 John Morgan Building
|
| Street address |
3620 Hamilton Walk
|
| City |
Philadlephia |
| State/province |
Pennsylvania |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (8)
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| GSM7067673 |
Splenic T regulatory cells rep2 |
| GSM7067674 |
Small intestine T conventional cells rep1 |
| GSM7067675 |
Small intestine T regulatory cells rep1 |
| GSM7067676 |
Small intestine T conventional cells rep2 |
| GSM7067677 |
Small intestine T regulatory cells rep2 |
|
| Relations |
| BioProject |
PRJNA939149 |
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