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| Status |
Public on Jun 28, 2011 |
| Title |
Lack of Toll-like Receptor Signaling Improves Host Defense in Severe Septic Peritonitis in Severe Septic Peritonitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
TLRs are considered important for innate immune responses that combat bacterial infections. Here, the role of TLRs in severe septic peritonitis using the colon ascendens stent peritonitis (CASP) model was examined. We demonstrate that mice deficient for MyD88 and TRIF had markedly reduced bacterial numbers both in peritoneal cavity and peripheral blood, indicating that bacterial clearance in this model is inhibited by TLR signals. Moreover, survival of Myd88-/-;TrifLps2/Lps2 mice was significantly improved. The lack of TLR signals prevented the excessive induction of inflammatory cytokines and of IL 10. Notably, the expression of IFN-gamma, which has an essential protective role in septic peritonitis, and of IFN-regulated genes including several p47 and p65 GTPases as well as IP 10 was independent of TLR signaling. These results provide evidence that, in severe septic peritonitis, TLR deficiency balances the innate immune response in a favorable manner by attenuating deleterious responses such as excessive cytokine release, while leaving intact protective IFN-gamma production.
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| Overall design |
In this dataset, expression data of genes induced by septic peritonitis in spleens from TLR-deficient and wildtype mice are included. 3 groups (septic TLR-deficient mice, septic wildtype mice, and untreated wildtype mice) with 4 replicates each.
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| Contributor(s) |
Prazeres da Costa O, Holzmann B |
| Citation(s) |
21628330 |
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| Submission date |
Sep 23, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Olivia Prazeres da Costa |
| E-mail(s) |
[email protected]
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| Phone |
00498941404149
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| Organization name |
Technische Universität München
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| Department |
Medical Microbiology, Immunology and Hygiene
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| Street address |
Trogerstr. 30
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| City |
München |
| State/province |
Bavaria |
| ZIP/Postal code |
81675 |
| Country |
Germany |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA132735 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24327_RAW.tar |
44.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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