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| Status |
Public on Apr 03, 2024 |
| Title |
Gene expression profiling of human colorectal cancer cell lines [Affymetrix] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We observed human colorectal cancer cell lines obtained resistance under treatment, and resistant cells switched back to sensitive state when the treatment is withdrawn.
To understand gene expressions change during this process, we performed Affymetrix experiments for parental, R20 (resistant), and W20 (withdrawal treatment) clones for three colorectal cancer cell lines.
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| Overall design |
Parental is the original cell line, and R20 are the cells survived 20 cycles of cetuximab and natural killer cells treatment, W20 cells are the R20 cells cultured without treatment for another 20 cycles.
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| Contributor(s) |
Yanguang C, Jiawei Z |
| Citation(s) |
38544569 |
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| Submission date |
Feb 13, 2024 |
| Last update date |
Apr 04, 2024 |
| Contact name |
Yanguang Cao |
| E-mail(s) |
[email protected]
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| Organization name |
UNC Chapel Hill
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| Street address |
301 Pharmacy Ln
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| City |
Chapel Hill |
| State/province |
North Carolina |
| ZIP/Postal code |
27599 |
| Country |
USA |
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| Platforms (1) |
| GPL24324 |
[Clariom_S_Human_HT] Affymetrix Clariom S Assay HT, Human (Includes Pico Assay) |
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| Samples (27)
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| GSM8077224 |
LIM1215 cell line, Parental, Replicate 1 |
| GSM8077225 |
LIM1215 cell line, Parental, Replicate 2 |
| GSM8077226 |
LIM1215 cell line, Parental, Replicate 3 |
| GSM8077227 |
LIM1215 cell line, Resistant, Replicate 1 |
| GSM8077228 |
LIM1215 cell line, Resistant, Replicate 2 |
| GSM8077229 |
LIM1215 cell line, Resistant, Replicate 3 |
| GSM8077230 |
LIM1215 cell line, Reverse (Withdrawal treatment), Replicate 1 |
| GSM8077231 |
LIM1215 cell line, Reverse (Withdrawal treatment), Replicate 2 |
| GSM8077232 |
LIM1215 cell line, Reverse (Withdrawal treatment), Replicate 3 |
| GSM8077233 |
SW48 cell line, Parental, Replicate 1 |
| GSM8077234 |
SW48 cell line, Parental, Replicate 2 |
| GSM8077235 |
SW48 cell line, Parental, Replicate 3 |
| GSM8077236 |
SW48 cell line, Resistant, Replicate 1 |
| GSM8077237 |
SW48 cell line, Resistant, Replicate 2 |
| GSM8077238 |
SW48 cell line, Resistant, Replicate 3 |
| GSM8077239 |
SW48 cell line, Reverse (Withdrawal treatment), Replicate 1 |
| GSM8077240 |
SW48 cell line, Reverse (Withdrawal treatment), Replicate 2 |
| GSM8077241 |
SW48 cell line, Reverse (Withdrawal treatment), Replicate 3 |
| GSM8077242 |
Caco2 cell line, Parental, Replicate 1 |
| GSM8077243 |
Caco2 cell line, Parental, Replicate 2 |
| GSM8077244 |
Caco2 cell line, Parental, Replicate 3 |
| GSM8077245 |
Caco2 cell line, Resistant, Replicate 1 |
| GSM8077246 |
Caco2 cell line, Resistant, Replicate 2 |
| GSM8077247 |
Caco2 cell line, Resistant, Replicate 3 |
| GSM8077248 |
Caco2 cell line, Reverse (Withdrawal treatment), Replicate 1 |
| GSM8077249 |
Caco2 cell line, Reverse (Withdrawal treatment), Replicate 2 |
| GSM8077250 |
Caco2 cell line, Reverse (Withdrawal treatment), Replicate 3 |
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| Relations |
| BioProject |
PRJNA1076137 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE255674_RAW.tar |
35.2 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
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