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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Oct 13, 2011 |
| Title |
Beta-catenin Controls Metastasis in Braf-activated Pten-inactivated Melanomas |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Malignant melanoma is characterized by frequent metastasis, however specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating beta-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and BrafV600E mutation, we demonstrate that beta-catenin is a central mediator of melanoma metastasis to lymph node and lung. In addition to altering metastasis, beta-catenin levels control tumor differentiation and regulate both MAPK/Erk and PI3K/Akt signaling. Highly metastatic tumors with beta-catenin stabilization are very similar to a subset of human melanomas; together these findings establish Wnt signaling as a metastasis regulator in melanoma.
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| Overall design |
MoGene-1_0-st-v1: Four samples total. Two biological replicates of uncultured Pten/Braf murine melanomas and two biological replicates of uncultured Pten/Braf/Bcat-STA murine melanomas.
MoEx-1_0-st-v1: Two samples total. Dissociated tumor and FACS-enriched Pten/Braf and Pten/Braf/Bcat-STA murine melanoma.
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| Contributor(s) |
Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Rothberg BG, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M |
| Citation(s) |
22172720 |
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| Submission date |
Oct 12, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
William Damsky |
| Organization name |
Yale School of Meicine
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| Department |
Dermatology
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| Street address |
333 Cedar St, LCI 501
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| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
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| Platforms (2) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA146587 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE32907_RAW.tar |
62.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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