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Series GSE32962 Query DataSets for GSE32962
Status Public on Oct 13, 2011
Title In vitro prednisolone resistance signature in MLL-rearranged infant ALL
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Acute Lymphoblastic Leukemia (ALL) in infants (<1 year of age) is characterized by a high incidence of MLL translocations which is associated with a poor prognosis. Contributing to this poor prognosis is cellular drug resistance, especially to glucocorticoids like prednisolone. Although in vitro prednisolone resistance mechanisms have been proposed in pediatric ALL, it has never been studied in MLL-rearranged infant ALL, which are highly resistant to glucocorticoids in vitro and in vivo.
 
Overall design We analyzed primary MLL-rearranged infant ALL expression profiles, which were either in vitro prednisolone-resistant or prednisolone-sensitive, in order to study in vitro prednisolone resistance.
 
Contributor(s) Spijkers-Hagelstein JA, Stam RW
Citation(s) 22282267
Submission date Oct 13, 2011
Last update date Mar 25, 2019
Contact name Jill Spijkers-Hagelstein
E-mail(s) [email protected]
Phone +31107043951
Organization name ErasmusMC - Sophia's Childrens Hospital
Department Pediatric Oncology
Street address Dr Molewaterplein 50
City Rotterdam
ZIP/Postal code 3015 GE
Country Netherlands
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (43)
GSM816393 MLL-rearranged infant ALL in vitro resistant to prednisolone 1
GSM816394 MLL-rearranged infant ALL in vitro resistant to prednisolone 2
GSM816395 MLL-rearranged infant ALL in vitro resistant to prednisolone 3
Relations
BioProject PRJNA146413

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE32962_RAW.tar 213.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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