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| Status |
Public on Sep 27, 2013 |
| Title |
Sub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle control (olive oil) for 28 days and sacrificed three days after the final exposure.
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| Overall design |
This experiment examined the forestomach transcriptional response of male mice exposed to BaP for 28 days at three different doses, including D1 (25 mg/kg BW/day), D2 (50 mg/kg BW/day), and D3 (75 mg/kg BW/day) and vehicle control. Each dose group was examined 72 hours following the final exposure. Each dose group and time point had 4-5 biological replicates. There were a total 17 samples (arrays) included in the final analysis using a two-colour reference design.
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| Contributor(s) |
Williams A, Labib S, Halappanavar S, Guo C, Yauk CL, White PA |
| Citation(s) |
23735875 |
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| Submission date |
Jan 11, 2013 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Sarah Labib |
| Organization name |
Health Canada
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| Street address |
204b-50 Colombine
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| City |
Ottawa |
| State/province |
Ontario |
| ZIP/Postal code |
K1A0K9 |
| Country |
Canada |
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| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA186427 |
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