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| Status |
Public on Jul 08, 2006 |
| Title |
Loss of BMPR2 Signaling in Smooth Muscle in Mouse Lung |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Mice expressing a doxycycline-inducible dominant negative BMPR2 transgene expressed only in smooth muscle are activated for one or eight weeks, and compared to transactivator-only mice also fed doxycycline. All mice are 12 weeks of old at sacrifice.
Keywords: time course with SM22-rtTA x tetO7-BMPR2 transgene
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| Overall design |
Each chip is a pool of three individual mice, to reduce variability. The transactivator-only mice are controls. The other mice all had elevated RV pressures at time of sacrifice. RNA was prepared from whole lung.
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| Contributor(s) |
Tada Y, Majka S, Carr M, Harral J, Crona D, Kuriyama T, West J |
| Citation(s) |
17369292 |
| |
| Submission date |
Jul 06, 2006 |
| Last update date |
Feb 11, 2019 |
| Contact name |
James West |
| E-mail(s) |
[email protected]
|
| Organization name |
Vanderbilt University
|
| Department |
Medicine
|
| Lab |
Pulmonary
|
| Street address |
4200 E 9TH Ave, Box B133
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37201 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
| GSM118653 |
Control Female FVB/N |
| GSM118658 |
Control Male SM22-rtTA only Lung |
| GSM119284 |
Lung from SM22-dnBMPR2 inducible transgenic females activated 1 week |
| GSM119285 |
Lung from SM22-dnBMPR2 inducible transgenic males activated 1 week |
| GSM119286 |
Lung from SM22-dnBMPR2 inducible transgenic females activated 8 weeks |
| GSM119287 |
Lung from SM22-dnBMPR2 inducible transgenic males activated 8 weeks |
|
| Relations |
| BioProject |
PRJNA96473 |
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