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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 24, 2015 |
| Title |
Expression data from proximal jejunum of WT vs. TLR2 KO mice after methotrexate (MTX) treatment |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The role of innate immunity in modulating severity of chemotherapy-induced complications is so far unclear. The aim of this study was to determine how TLR2 may influence MTX-induced mucositis in the small intestine in mice. We used microarrays to assess gene expression profiles in proximal jejunum of WT vs. TLR2 KO mice after systemic treatment with MTX.
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| Overall design |
Mucositis was induced by i.p. injection of MTX [40mg/kg BW/d] for 4 days in WT or TLR2 knockout (KO) mice. On day 7, mice were sacrificed and RNA was extracted from proximal jejunum (n=3 mice/group) and hybridized on Affymetrix microarrays.
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| Contributor(s) |
Cario E, Frank M |
| Citation(s) |
25589072 |
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| Submission date |
Apr 01, 2014 |
| Last update date |
Apr 18, 2017 |
| Contact name |
Elke Cario |
| E-mail(s) |
[email protected]
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| Phone |
+49-201-723-4527
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| Organization name |
University of Duisburg-Essen, University Hospital of Essen
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| Department |
Division of Gastroenterology and Hepatology
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| Lab |
Cario
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| Street address |
Virchowstr. 171
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| City |
Essen |
| State/province |
NRW |
| ZIP/Postal code |
45147 |
| Country |
Germany |
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| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM1361235 |
KO, - MTX, biological rep1 |
| GSM1361236 |
KO, - MTX, biological rep2 |
| GSM1361237 |
KO, - MTX, biological rep3 |
| GSM1361238 |
WT, + MTX, biological rep1 |
| GSM1361239 |
WT, + MTX, biological rep2 |
| GSM1361240 |
WT, + MTX, biological rep3 |
| GSM1361241 |
KO, + MTX, biological rep1 |
| GSM1361242 |
KO, + MTX, biological rep2 |
| GSM1361243 |
KO, + MTX, biological rep3 |
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| Relations |
| BioProject |
PRJNA243285 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE56426_RAW.tar |
51.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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