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| Status |
Public on Nov 19, 2007 |
| Title |
Early Gene Expression Profiles During Intraoperative Myocardial Ischemia-Reperfusion in Cardiac Surgery |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Right ventricular samples were serially acquired during surgical repair of ventricular septal defect. Expression profiling revealed three patterns of gene expression: (1) increased expression above control levels within one hour of cardioplegic arrest, with further amplification during early reperfusion; (2) increased expression limited to the reperfusion phase; and (3) reduced expression during reperfusion.
Keywords: VSD Patients
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| Overall design |
4 replicates each:
Stage2, End-ischemia
Stage1, Immediately post-cardioplegic arrest
Stage3, After 5 min. Reperfusion
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| Citation(s) |
17599489 |
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| Submission date |
Nov 28, 2006 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Sara Arab |
| Organization name |
Toronto General Hospital
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| Department |
Cardiology
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| Lab |
M. Husain
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| Street address |
610 University Avenue
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| City |
Toronto |
| State/province |
ONT |
| ZIP/Postal code |
M5G 2M9 |
| Country |
Canada |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (12)
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| GSM147135 |
Stage2, End-ischemia, Replicate4 |
| GSM147136 |
Stage1, Immediately post-cardioplegic arrest, Replicate1 |
| GSM147137 |
Stage1, Immediately post-cardioplegic arrest, Replicate2 |
| GSM147138 |
Stage1, Immediately post-cardioplegic arrest, Replicate3 |
| GSM147139 |
Stage1, Immediately post-cardioplegic arrest, Replicate4 |
| GSM148145 |
Stage 3, after 5 min. Reperfusion, Replicate1 |
| GSM148146 |
Stage 3, after 5 min. Reperfusion, Replicate2 |
| GSM148147 |
Stage 3, after 5 min. Reperfusion, Replicate3 |
| GSM148149 |
Stage 3, after 5 min. Reperfusion, Replicate4 |
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| Relations |
| BioProject |
PRJNA99553 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE6381_RAW.tar |
40.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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