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| Status |
Public on Nov 10, 2015 |
| Title |
Near-whole-genome transcriptome analysis of gene expression in human skeletal muscle tissue at baseline in obese individuals with Type 2 Diabetes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of gene expression associated with exercise response. The hypothesis tested was that individuals with Type 2 Diabetes that failed to demonstrate exercise-induced metabolic improvements would also reflect this lack of response in their skeletal muscle transcriptional profile at baseline. Of 186 genes identified by microarray analysis, 70% were upregulated in Responders and downregulated in Non-responders. Several genes involved in substrate metabolism and mitochondrial biogenesis differed significantly between the groups at baseline. This differential baseline gene expression indicated that Non-responders had blunted oxidative capacity.
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| Overall design |
Total RNA extracted from baseline samples of skeletal muscle of obese individuals with Type 2 Diabetes who were characterized as either Responders or Non-responders was examined for differential expression of exercise response-assocated genes.
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| Contributor(s) |
Stephens NA, Xie H, Johannsen NM, Church TS, Smith SR, Sparks LM |
| Citation(s) |
26163877 |
| |
| Submission date |
Nov 06, 2015 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Lauren M. Sparks |
| E-mail(s) |
[email protected]
|
| Organization name |
FLORIDA HOSPITAL
|
| Department |
Translational Research Institute for Metabolism and Diabetes
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| Street address |
301 E. Princeton St
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| City |
Orlando |
| State/province |
FL |
| ZIP/Postal code |
32804 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA301633 |
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