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| Status |
Public on Jun 07, 2016 |
| Title |
Impact of tRNA-Glu(UUC) and tRNA-Arg(CCG) on mRNA stability |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Stable expression of tRNA-Glu(UUC) and tRNA-Arg(CCG) followed by whole-genome transcript stability measurements using a-amanitin mediated inhibition of RNA Pol II.
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| |
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| Overall design |
Transfer RNA loci chr1.trna5 (Glu-TTC) and chr16.trna1 (Arg-CCG) were stably over-expressed in MDA-MB-231 cells. Cells were treated with a-amanitin (10ug/mL) and samples were collected at 0- and 9-nr. The RNA samples were then profiled.
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| |
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| Contributor(s) |
Goodarzi H, Nguyen H, Zhang S, Tavazoie SF |
| Citation(s) |
27259150 |
| |
| Submission date |
Jan 28, 2016 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Hani Goodarzi |
| Organization name |
UCSF
|
| Department |
Biochemistry and Biophysics
|
| Street address |
600 16th St, GH S312D
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE77401 |
Modulated expression of specific tRNA species drives cancer progression |
|
| Relations |
| BioProject |
PRJNA310108 |
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