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Series GSE84422 Query DataSets for GSE84422
Status Public on Aug 19, 2016
Title Molecular Signatures Underlying Selective Regional Vulnerability to Alzheimer's Disease
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Alzheimer's disease (AD) is the most common form of dementia, characterized by progressive cognitive impairment and neurodegeneration as a result of abnormal neuronal loss. To elucidate the molecular systems associated with AD, we characterized the gene expression changes associated with multiple clinical and neuropathological traits in 1,053 postmortem brain samples across 19 brain regions from 125 persons dying with varying severities of dementia and variable AD-neuropathology severities.
 
Overall design 125 human brains were accessed from the Mount Sinai/JJ Peters VA Medical Center Brain Bank (MSBB). This brain resource was assembled after applying stringent inclusion/exclusion criteria and represents the full spectrum of clinical and neuropathological disease severity in the absence of discernable non-AD neuropathology. RNA samples from 19 brain regions isolated from the 125 MSBB specimens were collected and profiled using Affymetrix Genechip microarrays. There were 50 to 60 subjects per brain region with varying degrees of AD pathological abnormalities.
 
Contributor(s) Wang M, Roussos P, Pavel K, Haroutunian V, Zhang B
Citation(s) 27799057
Submission date Jul 14, 2016
Last update date Jun 26, 2019
Contact name Bin Zhang
Organization name Icahn School of Medicine at Mount Sinai
Department Genetics and Genomic Sciences
Street address 1470 Madison Avenue
City New York
State/province NY
ZIP/Postal code 10029
Country USA
 
Platforms (3)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (2004)
GSM2233519 Subject 495, region Amygdala
GSM2233520 Subject 551, region Amygdala
GSM2233521 Subject 625, region Amygdala
Relations
BioProject PRJNA329139

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Supplementary file Size Download File type/resource
GSE84422_RAW.tar 6.6 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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