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| Status |
Public on Jul 22, 2017 |
| Title |
DKK3 overexpression increases malignant property in head and neck squamous cell carcinoma-derived HSC-3 cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We hypothesized that DKK3 may exert oncogenic function supecifically in head and neck squamous cell carcinoma (HNSCC). DKK3 overexpression in HNSCC cell resulted in elevated cellular proliferation, migration, invasion and in vivo tumor growth.
This elevated malignant properties was not driven by Wnt/beta-catenin pathway.
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| |
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| Overall design |
Single analysis for each condition (HSC-3 no transfection, HSC-3 GFP transfection and HSC-3 DKK3 transfection)
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| |
|
| Contributor(s) |
Katase N |
| Citation(s) |
28470144 |
| |
| Submission date |
Jul 22, 2016 |
| Last update date |
Aug 25, 2017 |
| Contact name |
Satoshi Kondo |
| Organization name |
Toray Industries,Inc.
|
| Street address |
10-1 tebiro 6-chome
|
| City |
Kamakura |
| State/province |
Kanagawa |
| ZIP/Postal code |
248-8555 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL13915 |
3D-Gene Human Oligo chip 25k V2.1 |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA330950 |
