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| Status |
Public on Sep 22, 2008 |
| Title |
The Transcriptome of the rat hypothalamo-neurohypophyseal system is highly strain-dependant |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
We have used microarrays to comprehensively describe the transcriptomes of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and the neurointermediate lobe (NIL) of adult male Sprague-Dawley (SD) and Wistar-Kyoto (WKY) rats, as well as the paraventricular nucleus of Wistar (WIST) rats. Comparison of these gene lists has enabled us to identify surprisingly large differences in hypothalamo-neurohypophyseal system gene expression patterns in these three strains. We have also shown that different transcript populations are enriched in the PVN and the SON of SD and WKY rats. The transcriptome differences catalogued here may be molecular substrates for the neuro-humoral phenotypic differences exhibited by different strains of rats.
Keywords: Transcriptome, Hypothalamo-neurohypophyseal system, Genetic
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| Overall design |
For each experimental group (SON-WKY, PVN-WKY, NIL-WKY, SON-SD, PVN-SD, NIL-SD, PVN-WISTAR) five chips were hybridised with independantly pooled RNA from a biological n=5.
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| Contributor(s) |
Hindmarch C, Yao S, Hesketh S, Jessop D, Harbuz M, Paton J, Murphy D |
| Citation(s) |
18001331 |
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| Submission date |
Jul 16, 2007 |
| Last update date |
Jul 31, 2017 |
| Contact name |
DAVID MURPHY |
| Organization name |
University of Bristol
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| Department |
Medicine and Dentistry
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| Lab |
Laboratories for Integrative Neuroscience and Endocrinolgy
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| Street address |
Whitson Street
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| City |
Bristol |
| State/province |
AVON |
| ZIP/Postal code |
BS1 3NY |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (35)
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| Relations |
| BioProject |
PRJNA101587 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8491_RAW.tar |
69.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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