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| Status |
Public on Nov 30, 2016 |
| Title |
Epigenetic stress responses induce muscle stem cell aging by Hoxa9 developmental signals [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Background and Aims: Analysis of aging-induced impairments in satellite cells (SCs) – the stem cells of skeletal muscle that are required for its regeneration. Hox genes are known to control stem cell function and development of various tissues.
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| |
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| Overall design |
Hindlimb muscles from young adult (3-4 months) and old (22-28 months) C57BL/6J mice were injured by BaCl2 injection in order to induce satellite cell activation. Satellite cells were isolated 3 days after injury and gene expression was analyzed.
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| |
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| Contributor(s) |
Schwörer S, Tümpel S, Rudolph KL |
| Citation(s) |
27919074 |
| |
| Submission date |
Sep 27, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Friedrich Becker |
| E-mail(s) |
[email protected]
|
| Phone |
+49 3641 656838
|
| Organization name |
Leibniz Institute on Aging - Fritz Lipmann Institute
|
| Department |
Stem cell aging
|
| Lab |
Prof. Lenhard K. Rudolph
|
| Street address |
Beutenberg Strasse 11
|
| City |
Jena |
| State/province |
Thuringia |
| ZIP/Postal code |
07745 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE87812 |
Epigenetic stress responses induce muscle stem cell aging by Hoxa9 developmental signals |
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| Relations |
| BioProject |
PRJNA344669 |
| SRA |
SRP090515 |
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