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| Status |
Public on Aug 30, 2017 |
| Title |
RNA-sequencing of C.elegans isp-1 mutant and superoxide dismutase-isp-1 double mutants |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
isp-1;sod double mutants have decreased lifespan, increased resistance to oxidative stress and slow physiologic rates. We performed RNA sequencing to compare gene expression between isp-1 mutants and isp-1;sod-3 and isp-1;sod-5 double mutants
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| Overall design |
Nine biological replicates per genotype; mRNA was isolated individually from each replicate; three mRNA samples were pooled into one sample; three samples for WT, isp-1, isp-1;sod-3, isp-1;sod-5 were sequenced individually
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| |
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| Contributor(s) |
Van Raamsdonk JM, Johnson BK |
| Citation(s) |
28392283, 37372097 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 GM121756 |
Molecular mechanisms by which mild elevation of mitochondrial superoxide extends lifespan |
HARVARD UNIVERSITY (MEDICAL SCHOOL) |
Jeremy Michael Van Raamsdonk |
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| |
| Submission date |
Feb 23, 2017 |
| Last update date |
Sep 11, 2023 |
| Contact name |
Jeremy Michael Van Raamsdonk |
| Organization name |
McGill University
|
| Department |
Neurology and Neurosurgery
|
| Street address |
1001 Decarie Boulevard
|
| City |
Montreal |
| State/province |
QC |
| ZIP/Postal code |
H4A3J1 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL19757 |
Illumina NextSeq 500 (Caenorhabditis elegans) |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA376493 |
| SRA |
SRP100601 |
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