Organotypic hippocampal slice cultures of male, postnatal day 15 mice (C57B6/SJL) were maintained in culture for 15 days and treated with phosphate buffered saline (vehicle) for an additional 24 h. Cultures were maintained on filter inserts in Neurobasal media with B-27 supplement (Invitrogen) and 1mM glutamine. The sample consists of 12 slices from 4 mice. Data were analyzed with MAS 5.0 and scaled to 2500. Keywords = Alzheimer’s disease Keywords = neuroprotection Keywords = sAPPalpha