U.S. flag

An official website of the United States government

GTR Home > Conditions/Phenotypes > Lewy body dementia

Lewy body dementia

Synonyms
Autosomal dominant diffuse Lewy body disease; Diffuse Lewy body disease; Lewy Body Disease

Summary

Dementia with Lewy bodies (DLB) is a neurodegenerative disorder clinically characterized by dementia and parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Pathologically, Lewy bodies are present in a pattern more widespread than usually observed in Parkinson disease (see PD; 168600). Alzheimer disease (AD; 104300)-associated pathology and spongiform changes may also be seen (McKeith et al., 1996; Mizutani, 2000; McKeith et al., 2005). [from OMIM]

Available tests

61 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (61 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: GBA, GCB, GLUC, GBA1
    Summary: glucosylceramidase beta 1

  • Also known as: NACP, PARK1, PARK4, PD1, SNCA
    Summary: synuclein alpha

  • Also known as: , SNCB
    Summary: synuclein beta

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

Show allHide all

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.