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GTR Home > Conditions/Phenotypes > Spermatogenic failure, X-linked, 4

Spermatogenic failure, X-linked, 4

Summary

X-linked spermatogenic failure-4 (SPGFX4) is characterized by male infertility due to azoospermia or oligoasthenoteratozoospermia. Some patients show maturation arrest, and Sertoli cell-only phenotype has been observed (Hardy et al., 2021; Arafat et al., 2021; Kherraf et al., 2022). For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: ACRC, NAAR1, SPGFX4, GCNA
    Summary: germ cell nuclear acidic peptidase

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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