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GTR Home > Conditions/Phenotypes > Spermatogenic failure, x-linked, 8

Spermatogenic failure, x-linked, 8

Summary

X-linked spermatogenic failure-8 (SPGFX8) is characterized by male infertility associated with markedly reduced progressive sperm motility. Patient sperm show head and midpiece defects, with deformed and detached acrosomes (Schneider et al., 2023; Jin et al., 2024). For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: CYCL1, SPGFX8, CYLC1
    Summary: cylicin 1

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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