IL13 interleukin 13
Gene ID: 3596, updated on 4-Jan-2025Gene type: protein coding
Also known as: P600; IL-13
- See all available tests in GTR for this gene
- Go to complete Gene record for IL13
- Go to Variation Viewer for IL13 variants
Summary
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. GeneReviews: Not available | |
| A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. GeneReviews: Not available | |
| A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. GeneReviews: Not available | |
| A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. GeneReviews: Not available | |
| A large-scale, consortium-based genomewide association study of asthma. GeneReviews: Not available | |
| A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. GeneReviews: Not available | |
| Allergic rhinitis, susceptibility to | not available |
| Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. GeneReviews: Not available | |
| Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. GeneReviews: Not available | |
| Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. GeneReviews: Not available | |
| Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. GeneReviews: Not available | |
| Inherited susceptibility to asthma | See labs |
Genomic context
- Location:
- 5q31.1
- Sequence:
- Chromosome: 5; NC_000005.10 (132656522..132661110)
- Total number of exons:
- 6
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for IL13 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- IL13 database
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.