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AXL AXL receptor tyrosine kinase

Gene ID: 558, updated on 27-Nov-2024
Gene type: protein coding
Also known as: ARK; UFO; AXL3; JTK11; Tyro7

Summary

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]

Genomic context

Location:
19q13.2
Sequence:
Chromosome: 19; NC_000019.10 (41219223..41261766)
Total number of exons:
21

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