DHX37 DEAH-box helicase 37

Gene ID: 57647, updated on 11-Jan-2025
Gene type: protein coding
Also known as: Dhr1; DDX37; SRXY11; NEDBAVC

Summary

This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

Description	Tests
Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies MedGen: C5231481OMIM: 618731GeneReviews: Not available	See labs
Vanishing testis MedGen: C0266427OMIM: 273250GeneReviews: Nonsyndromic Disorders of Testicular Development Overview	See labs

Genomic context

Location:: 12q24.31

Sequence:: Chromosome: 12; NC_000012.12 (124946826..124989131, complement)

Total number of exons:: 28

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Variation

Resource	Links for this gene
ClinVar	Variants reported to ClinVar
dbVar	Studies and variants
SNP	Variation Viewer for DHX37 variants
Genome viewer	Explore NCBI-annotated and select non-NCBI annotated genome assemblies

Links

ClinVar
Related medical variations
dbVar
Link from Gene to dbVar
MedGen
Related information in MedGen
OMIM
Link to related OMIM entry
PubMed (OMIM)
Gene links to PubMed derived from omim_pubmed_cited links
RefSeq RNAs
Link to Nucleotide RefSeq RNAs
Variation Viewer
Related Variants

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