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Multiple sclerosis

MedGen UID:
10123
•Concept ID:
C0026769
•
Disease or Syndrome
Synonyms: Disseminated Sclerosis; MS (Multiple Sclerosis); Multiple Sclerosis; Sclerosis, Disseminated; Sclerosis, Multiple
SNOMED CT: Disseminated sclerosis (24700007); MS - Multiple sclerosis (24700007); DS - Disseminated sclerosis (24700007); Multiple sclerosis (24700007)
 
Monarch Initiative: MONDO:0005301
Orphanet: ORPHA802

Definition

A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers. [from NCI]

Professional guidelines

PubMed

Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria.
Banwell B, Bennett JL, Marignier R, Kim HJ, Brilot F, Flanagan EP, Ramanathan S, Waters P, Tenembaum S, Graves JS, Chitnis T, Brandt AU, Hemingway C, Neuteboom R, Pandit L, Reindl M, Saiz A, Sato DK, Rostasy K, Paul F, Pittock SJ, Fujihara K, Palace J
Lancet Neurol 2023 Mar;22(3):268-282. Epub 2023 Jan 24 doi: 10.1016/S1474-4422(22)00431-8. PMID: 36706773
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.
Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA
Lancet Neurol 2018 Feb;17(2):162-173. Epub 2017 Dec 21 doi: 10.1016/S1474-4422(17)30470-2. PMID: 29275977
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, de Seze J, Fujihara K, Greenberg B, Jacob A, Jarius S, Lana-Peixoto M, Levy M, Simon JH, Tenembaum S, Traboulsee AL, Waters P, Wellik KE, Weinshenker BG; International Panel for NMO Diagnosis
Neurology 2015 Jul 14;85(2):177-89. Epub 2015 Jun 19 doi: 10.1212/WNL.0000000000001729. PMID: 26092914Free PMC Article

Curated

UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023

UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

Recent clinical studies

Etiology

Ageing and multiple sclerosis.
Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJM, Segal BM
Lancet Neurol 2023 Jan;22(1):66-77. Epub 2022 Oct 7 doi: 10.1016/S1474-4422(22)00184-3. PMID: 36216015
Multiple sclerosis - a review.
Dobson R, Giovannoni G
Eur J Neurol 2019 Jan;26(1):27-40. Epub 2018 Nov 18 doi: 10.1111/ene.13819. PMID: 30300457
Multiple sclerosis.
Cotsapas C, Mitrovic M, Hafler D
Handb Clin Neurol 2018;148:723-730. doi: 10.1016/B978-0-444-64076-5.00046-6. PMID: 29478610
Classification, diagnosis, and differential diagnosis of multiple sclerosis.
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774
Multiple sclerosis.
Compston A, Coles A
Lancet 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7. PMID: 18970977

Diagnosis

What Is Multiple Sclerosis?
Marcus R
JAMA 2022 Nov 22;328(20):2078. doi: 10.1001/jama.2022.14236. PMID: 36413229
Multiple sclerosis: clinical aspects.
Oh J, Vidal-Jordana A, Montalban X
Curr Opin Neurol 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239
Multiple sclerosis, a treatable disease.
Doshi A, Chataway J
Clin Med (Lond) 2016 Dec;16(Suppl 6):s53-s59. doi: 10.7861/clinmedicine.16-6-s53. PMID: 27956442Free PMC Article
Epidemiology of Multiple Sclerosis.
Howard J, Trevick S, Younger DS
Neurol Clin 2016 Nov;34(4):919-939. Epub 2016 Aug 18 doi: 10.1016/j.ncl.2016.06.016. PMID: 27720001
Classification, diagnosis, and differential diagnosis of multiple sclerosis.
Katz Sand I
Curr Opin Neurol 2015 Jun;28(3):193-205. doi: 10.1097/WCO.0000000000000206. PMID: 25887774

Therapy

Stem cell therapy for neurological disorders.
Alessandrini M, Preynat-Seauve O, De Bruin K, Pepper MS
S Afr Med J 2019 Sep 10;109(8b):70-77. doi: 10.7196/SAMJ.2019.v109i8b.14009. PMID: 31662153
Rehabilitation for people with multiple sclerosis: an overview of Cochrane Reviews.
Amatya B, Khan F, Galea M
Cochrane Database Syst Rev 2019 Jan 14;1(1):CD012732. doi: 10.1002/14651858.CD012732.pub2. PMID: 30637728Free PMC Article
Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis.
Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T
BMC Neurol 2014 Mar 25;14:58. doi: 10.1186/1471-2377-14-58. PMID: 24666846Free PMC Article
Pirfenidone.
Lasky J
IDrugs 2004 Feb;7(2):166-72. PMID: 15057662
Natalizumab. Elan/Biogen.
Elices MJ
Curr Opin Investig Drugs 2003 Nov;4(11):1354-62. PMID: 14758775

Prognosis

Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition.
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P
Mult Scler 2020 Dec;26(14):1816-1821. Epub 2020 Nov 11 doi: 10.1177/1352458520970841. PMID: 33174475Free PMC Article
Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants.
Hanlon P, Nicholl BI, Jani BD, Lee D, McQueenie R, Mair FS
Lancet Public Health 2018 Jul;3(7):e323-e332. Epub 2018 Jun 14 doi: 10.1016/S2468-2667(18)30091-4. PMID: 29908859Free PMC Article
Autoimmunity in uveitis.
Ten Berge JC, Schreurs MWJ, van Daele PLA, Rothova A
Acta Ophthalmol 2018 Aug;96(5):481-485. Epub 2018 Jan 25 doi: 10.1111/aos.13652. PMID: 29369534
Epidemiology of multiple sclerosis.
Leray E, Moreau T, Fromont A, Edan G
Rev Neurol (Paris) 2016 Jan;172(1):3-13. Epub 2015 Dec 21 doi: 10.1016/j.neurol.2015.10.006. PMID: 26718593

Clinical prediction guides

Imaging markers of multiple sclerosis prognosis.
Louapre C, Bodini B, Lubetzki C, Freeman L, Stankoff B
Curr Opin Neurol 2017 Jun;30(3):231-236. doi: 10.1097/WCO.0000000000000456. PMID: 28362719
Assessing upper limb function in multiple sclerosis.
Lamers I, Feys P
Mult Scler 2014 Jun;20(7):775-84. Epub 2014 Mar 24 doi: 10.1177/1352458514525677. PMID: 24664300
Neurofilaments as biomarkers in multiple sclerosis.
Teunissen CE, Khalil M
Mult Scler 2012 May;18(5):552-6. Epub 2012 Apr 4 doi: 10.1177/1352458512443092. PMID: 22492131
Conventional MR imaging.
Traboulsee A, Li DK
Neuroimaging Clin N Am 2008 Nov;18(4):651-73, x. doi: 10.1016/j.nic.2008.07.001. PMID: 19068407
The diagnosis of multiple sclerosis.
Lublin FD
Curr Opin Neurol 2002 Jun;15(3):253-6. doi: 10.1097/00019052-200206000-00005. PMID: 12045721

Recent systematic reviews

Comparative efficacy of therapies for relapsing multiple sclerosis: a systematic review and network meta-analysis.
Samjoo IA, Drudge C, Walsh S, Tiwari S, Brennan R, Boer I, Häring DA, Klotz L, Adlard N, Banhazi J
J Comp Eff Res 2023 Jul;12(7):e230016. Epub 2023 Jun 2 doi: 10.57264/cer-2023-0016. PMID: 37265062Free PMC Article
Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials.
Morales-Suarez-Varela M, Collado Sánchez E, Peraita-Costa I, Llopis-Morales A, Soriano JM
Nutrients 2021 Sep 13;13(9) doi: 10.3390/nu13093179. PMID: 34579056Free PMC Article
The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis: a systematic review and meta-analysis.
Razazian N, Kazeminia M, Moayedi H, Daneshkhah A, Shohaimi S, Mohammadi M, Jalali R, Salari N
BMC Neurol 2020 Mar 13;20(1):93. doi: 10.1186/s12883-020-01654-y. PMID: 32169035Free PMC Article
Efficacy of aquatic therapy for multiple sclerosis: a systematic review.
Corvillo I, Varela E, Armijo F, Alvarez-Badillo A, Armijo O, Maraver F
Eur J Phys Rehabil Med 2017 Dec;53(6):944-952. Epub 2017 Feb 17 doi: 10.23736/S1973-9087.17.04570-1. PMID: 28215060
Multiple Sclerosis Relapses: Epidemiology, Outcomes and Management. A Systematic Review.
Kalincik T
Neuroepidemiology 2015;44(4):199-214. Epub 2015 May 20 doi: 10.1159/000382130. PMID: 25997994

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023
    • NICE, 2022
      UK NICE Guideline NG220, Multiple sclerosis in adults: management, 2022

    Consumer resources

    Reviews

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