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Lower respiratory tract infection

MedGen UID:
101764
Concept ID:
C0149725
Disease or Syndrome
Synonym: Lower respiratory tract infections
SNOMED CT: LRTI - Lower respiratory tract infection (50417007); Lower respiratory tract infection (50417007); Lower respiratory infection (50417007); Chest cold (50417007)

Definition

An acute or chronic, viral or bacterial infectious process that affects the lower respiratory tract. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLower respiratory tract infection

Professional guidelines

PubMed

Zhang XL, Zhang X, Hua W, Xie ZD, Liu HM, Zhang HL, Chen BQ, Chen Y, Sun X, Xu Y, Shu SN, Zhao SY, Shang YX, Cao L, Jia YH, Lin LN, Li J, Hao CL, Dong XY, Lin DJ, Xu HM, Zhao DY, Zeng M, Chen ZM, Huang LS
World J Pediatr 2024 Jan;20(1):11-25. Epub 2023 Dec 8 doi: 10.1007/s12519-023-00777-9. PMID: 38064012Free PMC Article
Chalmers SJ, Wylam ME
Methods Mol Biol 2020;2069:229-251. doi: 10.1007/978-1-4939-9849-4_16. PMID: 31523777
Midulla F, Petrarca L, Frassanito A, Di Mattia G, Zicari AM, Nenna R
Minerva Pediatr 2018 Dec;70(6):600-611. Epub 2018 Oct 18 doi: 10.23736/S0026-4946.18.05334-3. PMID: 30334624

Recent clinical studies

Etiology

Drysdale SB, Cathie K, Flamein F, Knuf M, Collins AM, Hill HC, Kaiser F, Cohen R, Pinquier D, Felter CT, Vassilouthis NC, Jin J, Bangert M, Mari K, Nteene R, Wague S, Roberts M, Tissières P, Royal S, Faust SN; HARMONIE Study Group
N Engl J Med 2023 Dec 28;389(26):2425-2435. doi: 10.1056/NEJMoa2309189. PMID: 38157500
Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group
N Engl J Med 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275. PMID: 35235726
Claassen-Weitz S, Lim KYL, Mullally C, Zar HJ, Nicol MP
Clin Microbiol Infect 2021 Sep;27(9):1262-1270. Epub 2021 Jun 7 doi: 10.1016/j.cmi.2021.05.034. PMID: 34111578Free PMC Article
Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, Simões EAF, Esser MT, Khan AA, Dubovsky F, Villafana T, DeVincenzo JP; Nirsevimab Study Group
N Engl J Med 2020 Jul 30;383(5):415-425. doi: 10.1056/NEJMoa1913556. PMID: 32726528
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708

Diagnosis

Azar MM
Chest 2024 Mar;165(3):559-572. Epub 2023 Oct 7 doi: 10.1016/j.chest.2023.10.005. PMID: 37813181
Oppenlander KE, Chung AA, Clabaugh D
Am Fam Physician 2023 Jul;108(1):52-57. PMID: 37440737
Joseph MM, Edwards A
Pediatr Emerg Med Pract 2019 Oct;16(10):1-24. Epub 2019 Oct 2 PMID: 31557431
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708
Reynolds JH, McDonald G, Alton H, Gordon SB
Br J Radiol 2010 Dec;83(996):998-1009. doi: 10.1259/bjr/31200593. PMID: 21088086Free PMC Article

Therapy

Drysdale SB, Cathie K, Flamein F, Knuf M, Collins AM, Hill HC, Kaiser F, Cohen R, Pinquier D, Felter CT, Vassilouthis NC, Jin J, Bangert M, Mari K, Nteene R, Wague S, Roberts M, Tissières P, Royal S, Faust SN; HARMONIE Study Group
N Engl J Med 2023 Dec 28;389(26):2425-2435. doi: 10.1056/NEJMoa2309189. PMID: 38157500
Simões EAF, Madhi SA, Muller WJ, Atanasova V, Bosheva M, Cabañas F, Baca Cots M, Domachowske JB, Garcia-Garcia ML, Grantina I, Nguyen KA, Zar HJ, Berglind A, Cummings C, Griffin MP, Takas T, Yuan Y, Wählby Hamrén U, Leach A, Villafana T
Lancet Child Adolesc Health 2023 Mar;7(3):180-189. Epub 2023 Jan 9 doi: 10.1016/S2352-4642(22)00321-2. PMID: 36634694Free PMC Article
Hammitt LL, Dagan R, Yuan Y, Baca Cots M, Bosheva M, Madhi SA, Muller WJ, Zar HJ, Brooks D, Grenham A, Wählby Hamrén U, Mankad VS, Ren P, Takas T, Abram ME, Leach A, Griffin MP, Villafana T; MELODY Study Group
N Engl J Med 2022 Mar 3;386(9):837-846. doi: 10.1056/NEJMoa2110275. PMID: 35235726
Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, Simões EAF, Esser MT, Khan AA, Dubovsky F, Villafana T, DeVincenzo JP; Nirsevimab Study Group
N Engl J Med 2020 Jul 30;383(5):415-425. doi: 10.1056/NEJMoa1913556. PMID: 32726528
Smith DK, Seales S, Budzik C
Am Fam Physician 2017 Jan 15;95(2):94-99. PMID: 28084708

Prognosis

Rai E, Alaraimi R, Al Aamri I
Paediatr Anaesth 2022 Feb;32(2):181-190. Epub 2021 Dec 27 doi: 10.1111/pan.14382. PMID: 34927318
Griffin MP, Yuan Y, Takas T, Domachowske JB, Madhi SA, Manzoni P, Simões EAF, Esser MT, Khan AA, Dubovsky F, Villafana T, DeVincenzo JP; Nirsevimab Study Group
N Engl J Med 2020 Jul 30;383(5):415-425. doi: 10.1056/NEJMoa1913556. PMID: 32726528
Cunningham S
Am J Perinatol 2018 May;35(6):553-556. Epub 2018 Apr 25 doi: 10.1055/s-0038-1637765. PMID: 29694995
van Rhee F, Wong RS, Munshi N, Rossi JF, Ke XY, Fosså A, Simpson D, Capra M, Liu T, Hsieh RK, Goh YT, Zhu J, Cho SG, Ren H, Cavet J, Bandekar R, Rothman M, Puchalski TA, Reddy M, van de Velde H, Vermeulen J, Casper C
Lancet Oncol 2014 Aug;15(9):966-74. Epub 2014 Jul 17 doi: 10.1016/S1470-2045(14)70319-5. PMID: 25042199
Lee N, Lui GC, Wong KT, Li TC, Tse EC, Chan JY, Yu J, Wong SS, Choi KW, Wong RY, Ngai KL, Hui DS, Chan PK
Clin Infect Dis 2013 Oct;57(8):1069-77. Epub 2013 Jul 21 doi: 10.1093/cid/cit471. PMID: 23876395

Clinical prediction guides

Tsalik EL, Rouphael NG, Sadikot RT, Rodriguez-Barradas MC, McClain MT, Wilkins DM, Woods CW, Swamy GK, Walter EB, El Sahly HM, Keitel WA, Mulligan MJ, Tuyishimire B, Serti E, Hamasaki T, Evans SR, Ghazaryan V, Lee MS, Lautenbach E; TRAP-LRTI Study Group; Antibacterial Resistance Leadership Group
Lancet Infect Dis 2023 Apr;23(4):484-495. Epub 2022 Dec 13 doi: 10.1016/S1473-3099(22)00735-6. PMID: 36525985Free PMC Article
Claassen-Weitz S, Lim KYL, Mullally C, Zar HJ, Nicol MP
Clin Microbiol Infect 2021 Sep;27(9):1262-1270. Epub 2021 Jun 7 doi: 10.1016/j.cmi.2021.05.034. PMID: 34111578Free PMC Article
Tumbarello M, Raffaelli F, Giannella M, Mantengoli E, Mularoni A, Venditti M, De Rosa FG, Sarmati L, Bassetti M, Brindicci G, Rossi M, Luzzati R, Grossi PA, Corona A, Capone A, Falcone M, Mussini C, Trecarichi EM, Cascio A, Guffanti E, Russo A, De Pascale G, Tascini C, Gentile I, Losito AR, Bussini L, Corti G, Ceccarelli G, Corcione S, Compagno M, Giacobbe DR, Saracino A, Fantoni M, Antinori S, Peghin M, Bonfanti P, Oliva A, De Gasperi A, Tiseo G, Rovelli C, Meschiari M, Shbaklo N, Spanu T, Cauda R, Viale P
Clin Infect Dis 2021 Nov 2;73(9):1664-1676. doi: 10.1093/cid/ciab176. PMID: 33618353
Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL
Proc Natl Acad Sci U S A 2018 Dec 26;115(52):E12353-E12362. Epub 2018 Nov 27 doi: 10.1073/pnas.1809700115. PMID: 30482864Free PMC Article
Lozano JM
BMJ Clin Evid 2007 Oct 10;2007 PMID: 19450362Free PMC Article

Recent systematic reviews

Manothummetha K, Mongkolkaew T, Tovichayathamrong P, Boonyawairote R, Meejun T, Srisurapanont K, Phongkhun K, Sanguankeo A, Torvorapanit P, Moonla C, Plongla R, Kates OS, Avery RK, Nematollahi S, Permpalung N
Clin Microbiol Infect 2023 Oct;29(10):1272-1279. Epub 2023 Apr 26 doi: 10.1016/j.cmi.2023.04.021. PMID: 37116860
Padhani ZA, Moazzam Z, Ashraf A, Bilal H, Salam RA, Das JK, Bhutta ZA
Cochrane Database Syst Rev 2021 Nov 18;11(11):CD013134. doi: 10.1002/14651858.CD013134.pub3. PMID: 34791642Free PMC Article
Garegnani L, Styrmisdóttir L, Roson Rodriguez P, Escobar Liquitay CM, Esteban I, Franco JV
Cochrane Database Syst Rev 2021 Nov 16;11(11):CD013757. doi: 10.1002/14651858.CD013757.pub2. PMID: 34783356Free PMC Article
Claassen-Weitz S, Lim KYL, Mullally C, Zar HJ, Nicol MP
Clin Microbiol Infect 2021 Sep;27(9):1262-1270. Epub 2021 Jun 7 doi: 10.1016/j.cmi.2021.05.034. PMID: 34111578Free PMC Article
Gadomski AM, Scribani MB
Cochrane Database Syst Rev 2014 Jun 17;2014(6):CD001266. doi: 10.1002/14651858.CD001266.pub4. PMID: 24937099Free PMC Article

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