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Disseminated candidiasis

MedGen UID:
102260
•Concept ID:
C0153252
•
Disease or Syndrome
Synonyms: Systemic candida infections; Systemic candidiasis
SNOMED CT: Disseminated candidiasis (70572005); Systemic candidiasis (70572005); Disseminated candidosis (70572005); Invasive candidiasis (70572005); Disseminated candida (70572005)
 
Monarch Initiative: MONDO:0042233

Definition

A fungal infection by any of the Candida species in two or more non-contiguous sterile body compartments. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated candidiasis

Professional guidelines

PubMed

Single or 2-Dose Micafungin Regimen for Treatment of Invasive Candidiasis: Therapia Sterilisans Magna!
Gumbo T
Clin Infect Dis 2015 Dec 1;61 Suppl 6:S635-42. doi: 10.1093/cid/civ715. PMID: 26567282
Developments in the treatment of candidiasis: more choices and new challenges.
Aperis G, Myriounis N, Spanakis EK, Mylonakis E
Expert Opin Investig Drugs 2006 Nov;15(11):1319-36. doi: 10.1517/13543784.15.11.1319. PMID: 17040194
Current treatment strategies for disseminated candidiasis.
Spellberg BJ, Filler SG, Edwards JE Jr
Clin Infect Dis 2006 Jan 15;42(2):244-51. Epub 2005 Dec 2 doi: 10.1086/499057. PMID: 16355336

Recent clinical studies

Etiology

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy.
Al Yazidi LS, Elsidig N, Wali Y, Nazir H
Pediatr Infect Dis J 2023 May 1;42(5):e146-e151. Epub 2023 Feb 16 doi: 10.1097/INF.0000000000003859. PMID: 36795580
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Invasive fungal infections in the ICU: how to approach, how to treat.
Paramythiotou E, Frantzeskaki F, Flevari A, Armaganidis A, Dimopoulos G
Molecules 2014 Jan 17;19(1):1085-119. doi: 10.3390/molecules19011085. PMID: 24445340Free PMC Article
Epidemiology of opportunistic invasive mycoses.
Kullberg BJ, Oude Lashof AM
Eur J Med Res 2002 May 31;7(5):183-91. PMID: 12069910

Diagnosis

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy.
Al Yazidi LS, Elsidig N, Wali Y, Nazir H
Pediatr Infect Dis J 2023 May 1;42(5):e146-e151. Epub 2023 Feb 16 doi: 10.1097/INF.0000000000003859. PMID: 36795580
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Use of T2MR in invasive candidiasis with and without candidemia.
Zacharioudakis IM, Zervou FN, Mylonakis E
Future Microbiol 2018 Aug;13:1165-1173. Epub 2018 May 24 doi: 10.2217/fmb-2018-0079. PMID: 29792512
Invasive fungal infections in the ICU: how to approach, how to treat.
Paramythiotou E, Frantzeskaki F, Flevari A, Armaganidis A, Dimopoulos G
Molecules 2014 Jan 17;19(1):1085-119. doi: 10.3390/molecules19011085. PMID: 24445340Free PMC Article

Therapy

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Chronic Disseminated Candidiasis in Children and the Role of Corticosteroids Therapy.
Al Yazidi LS, Elsidig N, Wali Y, Nazir H
Pediatr Infect Dis J 2023 May 1;42(5):e146-e151. Epub 2023 Feb 16 doi: 10.1097/INF.0000000000003859. PMID: 36795580
Candida urinary tract infections in adults.
Odabasi Z, Mert A
World J Urol 2020 Nov;38(11):2699-2707. Epub 2019 Oct 25 doi: 10.1007/s00345-019-02991-5. PMID: 31654220
Use of T2MR in invasive candidiasis with and without candidemia.
Zacharioudakis IM, Zervou FN, Mylonakis E
Future Microbiol 2018 Aug;13:1165-1173. Epub 2018 May 24 doi: 10.2217/fmb-2018-0079. PMID: 29792512
Epidemiology of opportunistic invasive mycoses.
Kullberg BJ, Oude Lashof AM
Eur J Med Res 2002 May 31;7(5):183-91. PMID: 12069910

Prognosis

Invasive candidiasis in pediatric intensive care units.
Singhi S, Deep A
Indian J Pediatr 2009 Oct;76(10):1033-44. Epub 2009 Nov 12 doi: 10.1007/s12098-009-0219-6. PMID: 19907936
Chronic disseminated candidiasis in patients with acute leukemia: emphasis on diagnostic definition and treatment.
Masood A, Sallah S
Leuk Res 2005 May;29(5):493-501. Epub 2004 Dec 30 doi: 10.1016/j.leukres.2004.10.003. PMID: 15755501
Retinal lesions as clues to disseminated bacterial and candidal infections: frequency, natural history, and etiology.
Rodríguez-Adrián LJ, King RT, Tamayo-Derat LG, Miller JW, Garcia CA, Rex JH
Medicine (Baltimore) 2003 May;82(3):187-202. doi: 10.1097/01.md.0000076008.64510.f1. PMID: 12792305
Hepatosplenic candidiasis. A manifestation of chronic disseminated candidiasis.
Kontoyiannis DP, Luna MA, Samuels BI, Bodey GP
Infect Dis Clin North Am 2000 Sep;14(3):721-39. doi: 10.1016/s0891-5520(05)70128-8. PMID: 10987117
Cutaneous and mucosal manifestations of the deep mycotic infections.
Meyer RD
Acta Derm Venereol Suppl (Stockh) 1986;121:57-72. PMID: 3521177

Clinical prediction guides

Epidemiology, Clinical Characteristics and Risk Factors for Severity of Chronic Disseminated Candidiasis in Jerusalem, Israel.
Cohen N, Orenbuch-Harroch E, Olshtain-Pops K, Lachish T, Korem M
Mycopathologia 2023 Dec;188(6):873-883. Epub 2023 Jun 16 doi: 10.1007/s11046-023-00755-9. PMID: 37326819
Chronic disseminated candidiasis and acute leukemia: Impact on survival and hematopoietic stem cell transplantation agenda.
Grateau A, Le Maréchal M, Labussière-Wallet H, Ducastelle-Leprêtre S, Nicolini FE, Thomas X, Morisset S, Michallet M, Ader F; Lyon HEMINF study Group
Med Mal Infect 2018 May;48(3):202-206. Epub 2018 Jan 4 doi: 10.1016/j.medmal.2017.12.004. PMID: 29307444
Anidulafungin: an echinocandin antifungal.
Pfaller MA
Expert Opin Investig Drugs 2004 Sep;13(9):1183-97. doi: 10.1517/13543784.13.9.1183. PMID: 15330749
Retinal lesions as clues to disseminated bacterial and candidal infections: frequency, natural history, and etiology.
Rodríguez-Adrián LJ, King RT, Tamayo-Derat LG, Miller JW, Garcia CA, Rex JH
Medicine (Baltimore) 2003 May;82(3):187-202. doi: 10.1097/01.md.0000076008.64510.f1. PMID: 12792305
Cutaneous and mucosal manifestations of the deep mycotic infections.
Meyer RD
Acta Derm Venereol Suppl (Stockh) 1986;121:57-72. PMID: 3521177

Recent systematic reviews

Acute disseminated candidiasis with skin lesions: a systematic review.
Guarana M, Nucci M
Clin Microbiol Infect 2018 Mar;24(3):246-250. Epub 2017 Aug 25 doi: 10.1016/j.cmi.2017.08.016. PMID: 28847765

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