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Malignant Neoplasm of the Middle Third of the Esophagus

MedGen UID:
102269
•Concept ID:
C0153414
•
Neoplastic Process
Synonyms: Ca middle third esophagus; Malignant Middle Third of Esophagus Neoplasm; Malignant Middle Third of Esophagus Tumor; Malignant Middle Third of the Esophagus Neoplasm; Malignant Middle Third of the Esophagus Tumor; Malignant neoplasm of middle third of esophagus; Malignant Neoplasm of Middle Third of Esophagus; Malignant tumor of middle third of esophagus; Malignant Tumor of Middle Third of Esophagus; Malignant Tumor of the Middle Third of the Esophagus
SNOMED CT: Ca middle third esophagus (187726001); Malignant tumor of middle third of esophagus (187726001); Malignant neoplasm of middle third of esophagus (187726001)

Definition

A primary or metastatic malignant neoplasm involving the middle third segment of the esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm of the Middle Third of the Esophagus

Professional guidelines

PubMed

Challenges and considerations in interpreting the age-dependent benefit of neoadjuvant treatment for adenocarcinoma of the esophagus and gastroesophageal junction.
Li K, Yan H, Ke T
Int J Surg 2024 Sep 1;110(9):5837-5840. doi: 10.1097/JS9.0000000000001606. PMID: 38728858Free PMC Article
The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Clinical characteristics and management of gastric tube cancer after esophagectomy.
Shirakawa Y, Noma K, Maeda N, Ninomiya T, Tanabe S, Kikuchi S, Kuroda S, Nishizaki M, Kagawa S, Kawahara Y, Okada H, Fujiwara T
Esophagus 2018 Jul;15(3):180-189. Epub 2018 Mar 27 doi: 10.1007/s10388-018-0611-2. PMID: 29951985

Recent clinical studies

Etiology

Inflammatory fibroid polyp of the esophagus: a systematic review.
Mylonakis A, Triantafyllou T, Papaconstantinou D, Katsaros I, Lyros O, Mylonas KS, Karavokyros I, Schizas D
Minerva Surg 2024 Oct;79(5):564-570. Epub 2024 Sep 11 doi: 10.23736/S2724-5691.24.10430-3. PMID: 39259144
Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition.
Botteri E, Peveri G, Berstad P, Bagnardi V, Hoff G, Heath AK, Cross AJ, Vineis P, Dossus L, Johansson M, Freisling H, Matta K, Huybrechts I, Chen SLF, B Borch K, Sandanger TM, H Nøst T, Dahm CC, Antoniussen CS, Tin Tin S, Fournier A, Marques C, Artaud F, Sánchez MJ, Guevara M, Santiuste C, Agudo A, Bajracharya R, Katzke V, Ricceri F, Agnoli C, Bergmann MM, Schulze MB, Panico S, Masala G, Tjønneland A, Olsen A, Stocks T, Manjer J, Aizpurua-Atxega A, Weiderpass E, Riboli E, Gunter MJ, Ferrari P
Eur J Epidemiol 2024 Feb;39(2):147-159. Epub 2024 Jan 5 doi: 10.1007/s10654-023-01059-4. PMID: 38180593
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, Liang J, Lin X, Luo D, Zheng R, Wang X, Sun G, Wang L, Zheng L, Guo H, Wu J, Xu N, Yang J, Zhang H, Cheng Y, Wang N, Chen L, Fan Z, Sun P, Yu H
J Clin Oncol 2016 May 1;34(13):1448-54. Epub 2016 Feb 16 doi: 10.1200/JCO.2015.63.5995. PMID: 26884585

Diagnosis

Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Primary acinic cell carcinoma of the esophagus.
Nie L, Wang Q, Meng F
Clin Res Hepatol Gastroenterol 2019 Aug;43(4):359-361. Epub 2018 Dec 11 doi: 10.1016/j.clinre.2018.11.006. PMID: 30552027
Acute esophageal necrosis.
Rodrigues BD, Dos Santos R, da Luz MM, Chaves E Silva F, Reis IG
Clin J Gastroenterol 2016 Dec;9(6):341-344. Epub 2016 Oct 11 doi: 10.1007/s12328-016-0692-1. PMID: 27730597
Tumors of the esophagus.
Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):401-11. doi: 10.1007/s002689910065. PMID: 10706912
Esophageal sarcomas.
Perch SJ, Soffen EM, Whittington R, Brooks JJ
J Surg Oncol 1991 Nov;48(3):194-8. doi: 10.1002/jso.2930480311. PMID: 1658495

Therapy

Clinical outcomes and ctDNA correlates for CAPOX BETR: a phase II trial of capecitabine, oxaliplatin, bevacizumab, trastuzumab in previously untreated advanced HER2+ gastroesophageal adenocarcinoma.
Singh H, Lowder KE, Kapner K, Kelly RJ, Zheng H, McCleary NJ, Abrams TA, Chan JA, Regan EM, Klempner SJ, Hannigan AM, Remland J, Brais LK, Andrews E, Yurgelun M, Cleary JM, Rubinson DA, Ritterhouse LL, Maron G, Aguirre AJ, Meyerhardt JA, Gardecki E, Lennerz JK, Wolpin BM, Enzinger PC
Nat Commun 2024 Aug 9;15(1):6833. doi: 10.1038/s41467-024-51271-3. PMID: 39122726Free PMC Article
Esophageal cancer surgery in Greece during the era of the financial crisis.
Schizas D, Mylonas KS, Hasemaki N, Mpaili E, Ntomi V, Michalinos A, Theochari NA, Theochari CA, Mpoura M, Bakopoulos A, Liakakos T
Dis Esophagus 2021 Feb 10;34(2) doi: 10.1093/dote/doaa067. PMID: 32766686
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, Liang J, Lin X, Luo D, Zheng R, Wang X, Sun G, Wang L, Zheng L, Guo H, Wu J, Xu N, Yang J, Zhang H, Cheng Y, Wang N, Chen L, Fan Z, Sun P, Yu H
J Clin Oncol 2016 May 1;34(13):1448-54. Epub 2016 Feb 16 doi: 10.1200/JCO.2015.63.5995. PMID: 26884585
Primary lymphoma of the esophagus.
Gupta NM, Goenka MK, Jindal A, Behera A, Vaiphei K
J Clin Gastroenterol 1996 Oct;23(3):203-6. doi: 10.1097/00004836-199610000-00009. PMID: 8899502

Prognosis

Inflammatory fibroid polyp of the esophagus: a systematic review.
Mylonakis A, Triantafyllou T, Papaconstantinou D, Katsaros I, Lyros O, Mylonas KS, Karavokyros I, Schizas D
Minerva Surg 2024 Oct;79(5):564-570. Epub 2024 Sep 11 doi: 10.23736/S2724-5691.24.10430-3. PMID: 39259144
Epidemiology of gastrointestinal cancers: a systematic analysis from the Global Burden of Disease Study 2021.
Danpanichkul P, Suparan K, Tothanarungroj P, Dejvajara D, Rakwong K, Pang Y, Barba R, Thongpiya J, Fallon MB, Harnois D, Lui RN, Wallace MB, Yang JD, Roberts LR, Wijarnpreecha K
Gut 2024 Dec 10;74(1):26-34. doi: 10.1136/gutjnl-2024-333227. PMID: 39242191
Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
Tumors of the esophagus.
Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):401-11. doi: 10.1007/s002689910065. PMID: 10706912

Clinical prediction guides

Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition.
Botteri E, Peveri G, Berstad P, Bagnardi V, Hoff G, Heath AK, Cross AJ, Vineis P, Dossus L, Johansson M, Freisling H, Matta K, Huybrechts I, Chen SLF, B Borch K, Sandanger TM, H Nøst T, Dahm CC, Antoniussen CS, Tin Tin S, Fournier A, Marques C, Artaud F, Sánchez MJ, Guevara M, Santiuste C, Agudo A, Bajracharya R, Katzke V, Ricceri F, Agnoli C, Bergmann MM, Schulze MB, Panico S, Masala G, Tjønneland A, Olsen A, Stocks T, Manjer J, Aizpurua-Atxega A, Weiderpass E, Riboli E, Gunter MJ, Ferrari P
Eur J Epidemiol 2024 Feb;39(2):147-159. Epub 2024 Jan 5 doi: 10.1007/s10654-023-01059-4. PMID: 38180593
Long-term efficacy and predictors of pembrolizumab-based regimens in patients with advanced esophageal cancer in the real world.
Wang HC, Huang X, Chen J, Li Y, Cong Y, Qu BL, Feng SQ, Liu F
World J Gastroenterol 2023 Nov 7;29(41):5641-5656. doi: 10.3748/wjg.v29.i41.5641. PMID: 38077159Free PMC Article
Esophageal cancer surgery in Greece during the era of the financial crisis.
Schizas D, Mylonas KS, Hasemaki N, Mpaili E, Ntomi V, Michalinos A, Theochari NA, Theochari CA, Mpoura M, Bakopoulos A, Liakakos T
Dis Esophagus 2021 Feb 10;34(2) doi: 10.1093/dote/doaa067. PMID: 32766686
Safety and Efficacy of Durvalumab and Tremelimumab Alone or in Combination in Patients with Advanced Gastric and Gastroesophageal Junction Adenocarcinoma.
Kelly RJ, Lee J, Bang YJ, Almhanna K, Blum-Murphy M, Catenacci DVT, Chung HC, Wainberg ZA, Gibson MK, Lee KW, Bendell JC, Denlinger CS, Chee CE, Omori T, Leidner R, Lenz HJ, Chao Y, Rebelatto MC, Brohawn PZ, He P, McDevitt J, Sheth S, Englert JM, Ku GY
Clin Cancer Res 2020 Feb 15;26(4):846-854. Epub 2019 Nov 1 doi: 10.1158/1078-0432.CCR-19-2443. PMID: 31676670Free PMC Article
Novel stent in the palliation of malignant esophageal strictures: a retrospective study.
Chen H, Ni Z, Jing D, He L, Qiao L, Liu L, Wei X, Jiang M, Tang S, Xu H
Dis Esophagus 2017 Feb 1;30(3):1-5. doi: 10.1111/dote.12446. PMID: 26727310

Recent systematic reviews

Inflammatory fibroid polyp of the esophagus: a systematic review.
Mylonakis A, Triantafyllou T, Papaconstantinou D, Katsaros I, Lyros O, Mylonas KS, Karavokyros I, Schizas D
Minerva Surg 2024 Oct;79(5):564-570. Epub 2024 Sep 11 doi: 10.23736/S2724-5691.24.10430-3. PMID: 39259144
Role of thoracic endovascular aortic repair in T4b esophageal cancer management: a systematic review.
Papaconstantinou D, Koliakos N, Tzortzis AS, Mandrakas N, Bakopoulos A, Lianos GD, Peroulis M, Schizas D
Dis Esophagus 2024 Oct 28;37(11) doi: 10.1093/dote/doae058. PMID: 39058341
Effect of different surgical approaches on the survival and safety of Siewert type II esophagogastric junction adenocarcinoma: a systematic review and meta-analysis.
Zheng H, Yin X, Pan T, Tao X, Xu X, Li Z
BMC Cancer 2023 Nov 21;23(1):1130. doi: 10.1186/s12885-023-11640-5. PMID: 37990193Free PMC Article
The relationship between metabolic syndrome and increased risk of Barrett's esophagus: an updated systematic review and meta-analysis.
Karimian M, Salamati M, Azami M
BMC Gastroenterol 2020 May 6;20(1):138. doi: 10.1186/s12876-020-01267-2. PMID: 32375671Free PMC Article
Effectiveness of voice rehabilitation on vocalisation in postlaryngectomy patients: a systematic review.
Xi S
Int J Evid Based Healthc 2010 Dec;8(4):256-8. doi: 10.1111/j.1744-1609.2010.00177.x. PMID: 21091891

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