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Giant cell reparative granuloma

MedGen UID:
102385
•Concept ID:
C0162375
•
Disease or Syndrome
Synonym: Granuloma, Giant Cell Reparative
SNOMED CT: Central giant cell granuloma (15350006); CGCG - Central giant cell granuloma (15350006); Central giant cell reparative granuloma of jaw (15350006)
 
Monarch Initiative: MONDO:0006770

Definition

A localized, benign but sometimes aggressive osteolytic lesion of the jaws characterized by osteoclast-type giant cells in a vascular stroma. It more frequently affects the anterior jaws, in particular the mandible. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell reparative granuloma

Professional guidelines

PubMed

Occurrence of O'Brien-type annular elastolytic giant cell granuloma during pravastatin treatment illustrating statin-induced photosensitivity.
Breton C, Gusdorf L, Durlach A, Viguier M
Ann Dermatol Venereol 2023 Sep;150(3):232-234. Epub 2023 Apr 24 doi: 10.1016/j.annder.2023.03.002. PMID: 37100679
Regarding "Denosumab for the management of central giant cell granuloma of the jaws-a case series".
Kaban LB, Dodson TB
Int J Oral Maxillofac Surg 2022 Jun;51(6):844-845. Epub 2021 Oct 15 doi: 10.1016/j.ijom.2021.09.012. PMID: 34657767
Management of giant cell lesions.
Kaban LB, Dodson TB
Int J Oral Maxillofac Surg 2006 Nov;35(11):1074-5; author reply 1076. Epub 2006 Oct 20 doi: 10.1016/j.ijom.2006.08.010. PMID: 17055701

Recent clinical studies

Etiology

Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone of the Head: CT and MR Imaging Findings.
Li SL, Kong YG, Zou Y, Yu X, Ouyang HQ, Chen SM, Deng YQ
Comb Chem High Throughput Screen 2023;26(6):1180-1185. doi: 10.2174/1386207325666220818124912. PMID: 35984022
Giant cell reparative granuloma of the scapula: report of a case and literature review.
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456
Fibro-osseous lesions of the maxillofacial bones.
McCarthy EF
Head Neck Pathol 2013 Mar;7(1):5-10. Epub 2013 Mar 5 doi: 10.1007/s12105-013-0430-7. PMID: 23459840Free PMC Article
Cherubism: clinicopathologic features.
Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884
Giant cell reparative granuloma: presentation of one case and review of the literature.
Poli G, Di Liddo M, Fruscio A, Verni E, Lollini ME
Chir Organi Mov 1996 Apr-Jun;81(2):217-21. PMID: 8968125

Diagnosis

Giant-cell reparative granuloma of the hands and feet.
Eck HC, Weiner SD
Orthopedics 2004 Jan;27(1):67-70. doi: 10.3928/0147-7447-20040101-23. PMID: 14763535
Giant cell reparative granuloma of the hand: case report and review of giant cell lesions of hands and feet.
MacDonald DF, Binhammer PA, Rubenstein JD, Fornasier VL
Can J Surg 2003 Dec;46(6):471-3. PMID: 14680358Free PMC Article
Giant-cell reparative granuloma.
Palacios E, Valvassori G
Ear Nose Throat J 2000 Sep;79(9):688. PMID: 11011486
Giant cell reparative granuloma outside the jaw bone. Diagnostic criteria and review of the literature with the first case described in the temporal bone.
Hirschl S, Katz A
Hum Pathol 1974 Mar;5(2):171-81. doi: 10.1016/s0046-8177(74)80064-x. PMID: 4590573
The central giant cell reparative granuloma of the jaws. An analysis of 38 cases.
Waldron CA, Shafer WG
Am J Clin Pathol 1966 Apr;45(4):437-47. doi: 10.1093/ajcp/45.4.437. PMID: 5910047

Therapy

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review.
Weng JC, Li D, Wang L, Wu Z, Wang JM, Li GL, Jia W, Zhang LW, Zhang JT
J Neurosurg 2019 Sep 1;131(3):695-705. Epub 2018 Oct 12 doi: 10.3171/2018.4.JNS1849. PMID: 30497189
Effect of denosumab on recurrent giant cell reparative granuloma of the lumbar spine.
Akeda K, Kasai Y, Sakakibara T, Matsumine A, Takegami N, Yamada J, Sudo A
Spine (Phila Pa 1976) 2015 May 15;40(10):E601-8. doi: 10.1097/BRS.0000000000000862. PMID: 25955096
Giant cell reparative granuloma of the cranial vault-case report and review of literature.
Mukerji N, Willmott H, Joy A, Sutter R, Wadley J
Surg Neurol 2009 Apr;71(4):493-5. Epub 2008 Mar 4 doi: 10.1016/j.surneu.2007.09.042. PMID: 18291468
Alternative surgical treatment for giant-cell reparative granuloma in the metacarpal, using phenol and ethanol adjuvant therapy.
Yoshida T, Sakamoto A, Tanaka K, Matsuda S, Oda Y, Iwamoto Y
J Hand Surg Am 2007 Jul-Aug;32(6):887-92. doi: 10.1016/j.jhsa.2007.04.001. PMID: 17606072
Giant cell reparative granuloma of the temporal bone treated with calcitonin.
Souter MA, Bird PA, Worthington JP
Otol Neurotol 2006 Oct;27(7):999-1002. doi: 10.1097/01.mao.0000224076.54978.f0. PMID: 16788413

Prognosis

Maxillary Giant Cell Granuloma: A Long-Term Follow-Up.
Arthur Md DM, Palacios E, Nguyen J
Ear Nose Throat J 2020 Jan;99(1):39-41. Epub 2019 Apr 23 doi: 10.1177/0145561319840867. PMID: 31012347
Giant cell reparative granuloma of the occipital bone.
Santos-Briz A, Lobato RD, Ramos A, Millán JM, Ricoy JR, Martínez-Tello FJ
Skeletal Radiol 2003 Mar;32(3):151-5. Epub 2002 Dec 7 doi: 10.1007/s00256-002-0563-3. PMID: 12605280
Giant cell reparative granuloma of the temporal bone: neuroradiological and immunohistochemical findings.
Yoshimura J, Onda K, Tanaka R, Takahashi H
Neurol Med Chir (Tokyo) 2002 Nov;42(11):510-5. doi: 10.2176/nmc.42.510. PMID: 12472217
Peripheral giant-cell granuloma. Review of 13 cases.
Gandara-Rey JM, Pacheco Martins Carneiro JL, Gandara-Vila P, Blanco-Carrion A, García-García A, Madriñán-Graña P, Martín MS
Med Oral 2002 Jul-Oct;7(4):254-9. PMID: 12134126
Cherubism: clinicopathologic features.
Yamaguchi T, Dorfman HD, Eisig S
Skeletal Radiol 1999 Jun;28(6):350-3. doi: 10.1007/s002560050530. PMID: 10450884

Clinical prediction guides

Orbital Giant Cell Reparative Granuloma: A Case Report.
Wang N, Li J, Ma J
Ophthalmic Plast Reconstr Surg 2024 May-Jun 01;40(3):e97-e102. Epub 2024 May 10 doi: 10.1097/IOP.0000000000002622. PMID: 38738724Free PMC Article
Significance of Histone H3.3 (G34W)-Mutant Protein in Pathological Diagnosis of Giant Cell Tumor of Bone.
Miskad UA, Syamsul F, Dahlan H, Sungowati NK, Achmad D, Johan MP
Asian Pac J Cancer Prev 2023 May 1;24(5):1737-1741. doi: 10.31557/APJCP.2023.24.5.1737. PMID: 37247296Free PMC Article
Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone of the Head: CT and MR Imaging Findings.
Li SL, Kong YG, Zou Y, Yu X, Ouyang HQ, Chen SM, Deng YQ
Comb Chem High Throughput Screen 2023;26(6):1180-1185. doi: 10.2174/1386207325666220818124912. PMID: 35984022
Diffuse Tenosynovial Giant Cell Tumor Around the Temporomandibular Joint: An Entity With Special Radiologic and Pathologic Features.
Wang JG, Liu J, He B, Gao L, Zhang L, Liu J
J Oral Maxillofac Surg 2019 May;77(5):1022.e1-1022.e39. Epub 2019 Jan 29 doi: 10.1016/j.joms.2019.01.025. PMID: 30796908
Giant cell reparative granuloma of the scapula: report of a case and literature review.
Angelini A, Pagliarini E, Belluzzi E, Cappellesso R, Ruggieri P
Skeletal Radiol 2019 Aug;48(8):1293-1298. Epub 2019 Jan 4 doi: 10.1007/s00256-018-3132-0. PMID: 30607456

Recent systematic reviews

Surgical management and long-term outcomes of intracranial giant cell tumors: a single-institution experience with a systematic review.
Weng JC, Li D, Wang L, Wu Z, Wang JM, Li GL, Jia W, Zhang LW, Zhang JT
J Neurosurg 2019 Sep 1;131(3):695-705. Epub 2018 Oct 12 doi: 10.3171/2018.4.JNS1849. PMID: 30497189

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