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Osteoradionecrosis

MedGen UID:
10500
•Concept ID:
C0029461
•
Pathologic Function
Synonym: Osteoradionecroses
SNOMED CT: Osteoradionecrosis (109333005); Radiation necrosis of bone (109333005); Osteonecrosis caused by ionizing radiation (109333005); Avascular necrosis caused by ionizing radiation (109333005)
 
Monarch Initiative: MONDO:0043735

Definition

Necrosis of bone following exposure to a source of radiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteoradionecrosis

Professional guidelines

PubMed

Medication-related osteonecrosis and osteoradionecrosis of the jaws: Update and current management.
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Dental Treatment Planning for the Patient with Oral Cancer.
Levi LE, Lalla RV
Dent Clin North Am 2018 Jan;62(1):121-130. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.009. PMID: 29126489
Treatment of late sequelae after radiotherapy for head and neck cancer.
Strojan P, Hutcheson KA, Eisbruch A, Beitler JJ, Langendijk JA, Lee AWM, Corry J, Mendenhall WM, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2017 Sep;59:79-92. Epub 2017 Jul 18 doi: 10.1016/j.ctrv.2017.07.003. PMID: 28759822Free PMC Article

Recent clinical studies

Etiology

Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.
Toneatti DJ, Graf RR, Burkhard JP, Schaller B
Clin Oral Investig 2021 Oct;25(10):5579-5593. Epub 2021 Aug 16 doi: 10.1007/s00784-021-04065-6. PMID: 34401944Free PMC Article
Osteoradionecrosis: Exposing the Evidence Not the Bone.
Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1206-1218. Epub 2021 Jan 4 doi: 10.1016/j.ijrobp.2020.12.043. PMID: 33412258
Medication-related osteonecrosis and osteoradionecrosis of the jaws: Update and current management.
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis.
Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS
Cancer Med 2017 Dec;6(12):2918-2931. Epub 2017 Oct 25 doi: 10.1002/cam4.1221. PMID: 29071801Free PMC Article
Osteoradionecrosis.
O'Dell K, Sinha U
Oral Maxillofac Surg Clin North Am 2011 Aug;23(3):455-64. doi: 10.1016/j.coms.2011.04.011. PMID: 21798443

Diagnosis

Osteoradionecrosis: Exposing the Evidence Not the Bone.
Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1206-1218. Epub 2021 Jan 4 doi: 10.1016/j.ijrobp.2020.12.043. PMID: 33412258
Medication-related osteonecrosis and osteoradionecrosis of the jaws: Update and current management.
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Dental Treatment Planning for the Patient with Oral Cancer.
Levi LE, Lalla RV
Dent Clin North Am 2018 Jan;62(1):121-130. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.009. PMID: 29126489
Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review.
Chronopoulos A, Zarra T, Ehrenfeld M, Otto S
Int Dent J 2018 Feb;68(1):22-30. Epub 2017 Jun 25 doi: 10.1111/idj.12318. PMID: 28649774Free PMC Article
Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis.
Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS
Cancer Med 2017 Dec;6(12):2918-2931. Epub 2017 Oct 25 doi: 10.1002/cam4.1221. PMID: 29071801Free PMC Article

Therapy

Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.
Toneatti DJ, Graf RR, Burkhard JP, Schaller B
Clin Oral Investig 2021 Oct;25(10):5579-5593. Epub 2021 Aug 16 doi: 10.1007/s00784-021-04065-6. PMID: 34401944Free PMC Article
Osteoradionecrosis: Exposing the Evidence Not the Bone.
Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1206-1218. Epub 2021 Jan 4 doi: 10.1016/j.ijrobp.2020.12.043. PMID: 33412258
Reconstruction of the mandible for osteoradionecrosis.
Haroun K, Coblens OM
Curr Opin Otolaryngol Head Neck Surg 2019 Oct;27(5):401-406. doi: 10.1097/MOO.0000000000000571. PMID: 31389851
Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review.
Chronopoulos A, Zarra T, Ehrenfeld M, Otto S
Int Dent J 2018 Feb;68(1):22-30. Epub 2017 Jun 25 doi: 10.1111/idj.12318. PMID: 28649774Free PMC Article
Osteoradionecrosis.
O'Dell K, Sinha U
Oral Maxillofac Surg Clin North Am 2011 Aug;23(3):455-64. doi: 10.1016/j.coms.2011.04.011. PMID: 21798443

Prognosis

Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis : A systematic review and meta-analysis.
Balermpas P, van Timmeren JE, Knierim DJ, Guckenberger M, Ciernik IF
Strahlenther Onkol 2022 Mar;198(3):219-228. Epub 2022 Jan 14 doi: 10.1007/s00066-021-01896-w. PMID: 35029717Free PMC Article
Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.
Toneatti DJ, Graf RR, Burkhard JP, Schaller B
Clin Oral Investig 2021 Oct;25(10):5579-5593. Epub 2021 Aug 16 doi: 10.1007/s00784-021-04065-6. PMID: 34401944Free PMC Article
Osteoradionecrosis: Exposing the Evidence Not the Bone.
Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1206-1218. Epub 2021 Jan 4 doi: 10.1016/j.ijrobp.2020.12.043. PMID: 33412258
Medication-related osteonecrosis and osteoradionecrosis of the jaws: Update and current management.
Kün-Darbois JD, Fauvel F
Morphologie 2021 Jun;105(349):170-187. Epub 2020 Dec 3 doi: 10.1016/j.morpho.2020.11.008. PMID: 33281055
Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis.
Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, Heaivilin N, Zumsteg ZS
Cancer Med 2017 Dec;6(12):2918-2931. Epub 2017 Oct 25 doi: 10.1002/cam4.1221. PMID: 29071801Free PMC Article

Clinical prediction guides

Prevention and Management of Osteoradionecrosis in Patients With Head and Neck Cancer Treated With Radiation Therapy: ISOO-MASCC-ASCO Guideline.
Peterson DE, Koyfman SA, Yarom N, Lynggaard CD, Ismaila N, Forner LE, Fuller CD, Mowery YM, Murphy BA, Watson E, Yang DH, Alajbeg I, Bossi P, Fritz M, Futran ND, Gelblum DY, King E, Ruggiero S, Smith DK, Villa A, Wu JS, Saunders D
J Clin Oncol 2024 Jun 1;42(16):1975-1996. Epub 2024 May 1 doi: 10.1200/JCO.23.02750. PMID: 38691821
Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis : A systematic review and meta-analysis.
Balermpas P, van Timmeren JE, Knierim DJ, Guckenberger M, Ciernik IF
Strahlenther Onkol 2022 Mar;198(3):219-228. Epub 2022 Jan 14 doi: 10.1007/s00066-021-01896-w. PMID: 35029717Free PMC Article
Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review.
Chronopoulos A, Zarra T, Ehrenfeld M, Otto S
Int Dent J 2018 Feb;68(1):22-30. Epub 2017 Jun 25 doi: 10.1111/idj.12318. PMID: 28649774Free PMC Article
Medical treatment of osteoradionecrosis of the mandible by PENTOCLO: preliminary results.
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781

Recent systematic reviews

Hyperbaric oxygen therapy for late radiation tissue injury.
Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Dental extraction, intensity-modulated radiotherapy of head and neck cancer, and osteoradionecrosis : A systematic review and meta-analysis.
Balermpas P, van Timmeren JE, Knierim DJ, Guckenberger M, Ciernik IF
Strahlenther Onkol 2022 Mar;198(3):219-228. Epub 2022 Jan 14 doi: 10.1007/s00066-021-01896-w. PMID: 35029717Free PMC Article
Survival of dental implants and occurrence of osteoradionecrosis in irradiated head and neck cancer patients: a systematic review and meta-analysis.
Toneatti DJ, Graf RR, Burkhard JP, Schaller B
Clin Oral Investig 2021 Oct;25(10):5579-5593. Epub 2021 Aug 16 doi: 10.1007/s00784-021-04065-6. PMID: 34401944Free PMC Article
Osteoradionecrosis: Exposing the Evidence Not the Bone.
Frankart AJ, Frankart MJ, Cervenka B, Tang AL, Krishnan DG, Takiar V
Int J Radiat Oncol Biol Phys 2021 Apr 1;109(5):1206-1218. Epub 2021 Jan 4 doi: 10.1016/j.ijrobp.2020.12.043. PMID: 33412258
Risk factors for osteoradionecrosis after head and neck radiation: a systematic review.
Nabil S, Samman N
Oral Surg Oral Med Oral Pathol Oral Radiol 2012 Jan;113(1):54-69. Epub 2012 Feb 3 doi: 10.1016/j.tripleo.2011.07.042. PMID: 22669065

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