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Abnormal serum osmolality

MedGen UID:
1053100
Concept ID:
CN377508
Finding
HPO: HP:6000679

Definition

Any deviation from the normal range of the serum osmolality, defined as the sum of the osmolalities of every single dissolved particle in the blood such as sodium and associated anions, potassium, glucose, and urea. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal serum osmolality

Professional guidelines

PubMed

Sakuma M, Misawa F, Maeda M, Fujii Y, Uchida H, Mimura M, Takeuchi H
Psychiatry Res 2021 Mar;297:113708. Epub 2021 Jan 4 doi: 10.1016/j.psychres.2021.113708. PMID: 33461119

Recent clinical studies

Etiology

Bhasin-Chhabra B, Veitla V, Weinberg S, Koratala A
Nutr Clin Pract 2022 Oct;37(5):1023-1032. Epub 2022 Aug 29 doi: 10.1002/ncp.10907. PMID: 36036229
Almalki MH, Ahmad MM, Brema I, Almehthel M, AlDahmani KM, Mahzari M, Beshyah SA
Sultan Qaboos Univ Med J 2021 Aug;21(3):354-364. Epub 2021 Aug 29 doi: 10.18295/squmj.4.2021.010. PMID: 34522399Free PMC Article
Lacey J, Corbett J, Forni L, Hooper L, Hughes F, Minto G, Moss C, Price S, Whyte G, Woodcock T, Mythen M, Montgomery H
Ann Med 2019 May-Jun;51(3-4):232-251. Epub 2019 Jun 17 doi: 10.1080/07853890.2019.1628352. PMID: 31204514Free PMC Article
Buffington MA, Abreo K
J Intensive Care Med 2016 May;31(4):223-36. Epub 2015 Jan 14 doi: 10.1177/0885066614566794. PMID: 25592330
Greenberg A, Verbalis JG
Kidney Int 2006 Jun;69(12):2124-30. Epub 2006 May 3 doi: 10.1038/sj.ki.5000432. PMID: 16672911

Diagnosis

Bhasin-Chhabra B, Veitla V, Weinberg S, Koratala A
Nutr Clin Pract 2022 Oct;37(5):1023-1032. Epub 2022 Aug 29 doi: 10.1002/ncp.10907. PMID: 36036229
Almalki MH, Ahmad MM, Brema I, Almehthel M, AlDahmani KM, Mahzari M, Beshyah SA
Sultan Qaboos Univ Med J 2021 Aug;21(3):354-364. Epub 2021 Aug 29 doi: 10.18295/squmj.4.2021.010. PMID: 34522399Free PMC Article
Seay NW, Lehrich RW, Greenberg A
Am J Kidney Dis 2020 Feb;75(2):272-286. Epub 2019 Oct 10 doi: 10.1053/j.ajkd.2019.07.014. PMID: 31606238
Buffington MA, Abreo K
J Intensive Care Med 2016 May;31(4):223-36. Epub 2015 Jan 14 doi: 10.1177/0885066614566794. PMID: 25592330
Yee AH, Burns JD, Wijdicks EF
Neurosurg Clin N Am 2010 Apr;21(2):339-52. doi: 10.1016/j.nec.2009.10.011. PMID: 20380974

Therapy

Leong XF, Cheng M, Jong B, Hwang NC, Roscoe A
J Cardiothorac Vasc Anesth 2021 Nov;35(11):3374-3384. Epub 2020 Jul 17 doi: 10.1053/j.jvca.2020.07.047. PMID: 32888797
Buffington MA, Abreo K
J Intensive Care Med 2016 May;31(4):223-36. Epub 2015 Jan 14 doi: 10.1177/0885066614566794. PMID: 25592330
Schreckinger M, Szerlip N, Mittal S
Clin Neurol Neurosurg 2013 Feb;115(2):121-6. Epub 2012 Aug 24 doi: 10.1016/j.clineuro.2012.08.009. PMID: 22921808
Greenberg A, Verbalis JG
Kidney Int 2006 Jun;69(12):2124-30. Epub 2006 May 3 doi: 10.1038/sj.ki.5000432. PMID: 16672911
Elgart HN
AACN Clin Issues 2004 Oct-Dec;15(4):607-21. doi: 10.1097/00044067-200410000-00011. PMID: 15586161

Prognosis

Gadoth A, Nisnboym M, Alcalay Y, Zubkov A, Schwartz I, Schwartz D, Abboud M, Rubinek T, Yossepowitch O, Weinstein T
Neurol Neuroimmunol Neuroinflamm 2023 Nov;10(6) Epub 2023 Aug 17 doi: 10.1212/NXI.0000000000200155. PMID: 37591767Free PMC Article
Ozbek B, Tanrıkulu N
Braz J Cardiovasc Surg 2020 Apr 1;35(2):155-159. doi: 10.21470/1678-9741-2019-0325. PMID: 32369294Free PMC Article
Lacey J, Corbett J, Forni L, Hooper L, Hughes F, Minto G, Moss C, Price S, Whyte G, Woodcock T, Mythen M, Montgomery H
Ann Med 2019 May-Jun;51(3-4):232-251. Epub 2019 Jun 17 doi: 10.1080/07853890.2019.1628352. PMID: 31204514Free PMC Article
Cakir U, Tayman C
Am J Perinatol 2019 May;36(6):641-646. Epub 2018 Oct 6 doi: 10.1055/s-0038-1673397. PMID: 30292174
Greenberg A, Verbalis JG
Kidney Int 2006 Jun;69(12):2124-30. Epub 2006 May 3 doi: 10.1038/sj.ki.5000432. PMID: 16672911

Clinical prediction guides

Almalki MH, Ahmad MM, Brema I, Almehthel M, AlDahmani KM, Mahzari M, Beshyah SA
Sultan Qaboos Univ Med J 2021 Aug;21(3):354-364. Epub 2021 Aug 29 doi: 10.18295/squmj.4.2021.010. PMID: 34522399Free PMC Article
Cakir U, Tayman C
Am J Perinatol 2019 May;36(6):641-646. Epub 2018 Oct 6 doi: 10.1055/s-0038-1673397. PMID: 30292174
Ferrer E
Drugs Today (Barc) 2010 Mar;46(3):163-71. doi: 10.1358/dot.2010.46.3.1464842. PMID: 20467590
Greenberg A, Verbalis JG
Kidney Int 2006 Jun;69(12):2124-30. Epub 2006 May 3 doi: 10.1038/sj.ki.5000432. PMID: 16672911
Jabbari B, Huott AD
Epilepsia 1980 Feb;21(1):91-6. doi: 10.1111/j.1528-1157.1980.tb04048.x. PMID: 6766396

Recent systematic reviews

Sakuma M, Misawa F, Maeda M, Fujii Y, Uchida H, Mimura M, Takeuchi H
Psychiatry Res 2021 Mar;297:113708. Epub 2021 Jan 4 doi: 10.1016/j.psychres.2021.113708. PMID: 33461119

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