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Immune hydrops fetalis

MedGen UID:
105328
Concept ID:
C0455990
Disease or Syndrome
Synonyms: Hydrops Fetalis, Immune; Immune Hydrops Fetalis
SNOMED CT: Immune hydrops fetalis (15539009); Hydrops fetalis due to isoimmunization (15539009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018221
Orphanet: ORPHA364013

Definition

Immune hydrops fetalis (IHF), a form of HF, describes the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities due to maternal rhesus (Rh) incompatibility. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmune hydrops fetalis

Professional guidelines

PubMed

Lin XM, Li DZ
Ultrasound Obstet Gynecol 2022 Oct;60(4):585-586. doi: 10.1002/uog.26063. PMID: 36183347
Désilets V, Audibert F; Society of Obstetrician and Gynaecologists of Canada
J Obstet Gynaecol Can 2013 Oct;35(10):923-38. doi: 10.1016/s1701-2163(15)30816-1. PMID: 24165062
Ettore G, Guarnera S, Bianca S
Prenat Diagn 1998 Nov;18(11):1213. PMID: 9854738

Recent clinical studies

Etiology

Ergani SY, İbanoğlu MC, Çakır A, Ateş Ç, Örgül G, Tonyalı NV, Çelik ÖY, Şahin D
Rev Assoc Med Bras (1992) 2024;70(7):e20231723. Epub 2024 Jul 19 doi: 10.1590/1806-9282.20231723. PMID: 39045931Free PMC Article
Giugliani R, Barth AL, Dumas MRC, da Silva Franco JF, de Rosso Giuliani L, Grangeiro CHP, Horovitz DDG, Kim CA, de Araújo Leão EKE, de Medeiros PFV, Miguel DSCG, Moreira MESA, Dos Santos HMGP, da Silva LCS, da Silva LR, de Souza IN, Nalin T, Garcia D
Orphanet J Rare Dis 2021 May 22;16(1):238. doi: 10.1186/s13023-021-01870-w. PMID: 34022924Free PMC Article
Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
J Ultrasound Med 2018 May;37(5):1185-1191. Epub 2017 Oct 27 doi: 10.1002/jum.14462. PMID: 29076544Free PMC Article
Bellini C, Donarini G, Paladini D, Calevo MG, Bellini T, Ramenghi LA, Hennekam RC
Am J Med Genet A 2015 May;167A(5):1082-8. Epub 2015 Feb 25 doi: 10.1002/ajmg.a.36988. PMID: 25712632
Santo S, Mansour S, Thilaganathan B, Homfray T, Papageorghiou A, Calvert S, Bhide A
Prenat Diagn 2011 Feb;31(2):186-95. Epub 2011 Jan 4 doi: 10.1002/pd.2677. PMID: 21268039

Diagnosis

To-Figueras J, Erwin AL, Aguilera P, Millet O, Desnick RJ
Liver Int 2024 Aug;44(8):1842-1855. Epub 2024 May 8 doi: 10.1111/liv.15958. PMID: 38717058
Gawie-Rotman M, Shrim A, Maor-Sagie E, Haggiag N, Gabbay-Benziv R, Hallak M
Isr Med Assoc J 2023 May;25(5):367-368. PMID: 37245109
Reytan S, Zunz Henig N, Yinon Y, Avnet H, Kurolap A, Yaron Y, Baris Feldman H
Prenat Diagn 2022 Jun;42(7):890-893. Epub 2022 Apr 11 doi: 10.1002/pd.6142. PMID: 35393661
Santo S, Mansour S, Thilaganathan B, Homfray T, Papageorghiou A, Calvert S, Bhide A
Prenat Diagn 2011 Feb;31(2):186-95. Epub 2011 Jan 4 doi: 10.1002/pd.2677. PMID: 21268039
Wraith JE
Semin Neonatol 2002 Feb;7(1):75-83. doi: 10.1053/siny.2001.0088. PMID: 12069540

Therapy

Désilets V, De Bie I, Audibert F
J Obstet Gynaecol Can 2018 Aug;40(8):1077-1090. doi: 10.1016/j.jogc.2017.12.011. PMID: 30103882
Asabe K, Oka Y, Shirakusa T
Congenit Anom (Kyoto) 2005 Sep;45(3):96-101. doi: 10.1111/j.1741-4520.2005.00075.x. PMID: 16131368
Ogburn PL Jr, Ramin KD, Danilenko-Dixon D, Fairbanks VF, Ramsey PS
Am J Obstet Gynecol 2001 Jul;185(1):238-9. doi: 10.1067/mob.2001.112395. PMID: 11483935
Anandakumar C, Biswas A, Chua TM, Choolani M, Chia D, Wong YC, Gole L
Ultrasound Obstet Gynecol 1999 Apr;13(4):263-5. doi: 10.1046/j.1469-0705.1999.13040263.x. PMID: 10341405
Negishi H, Yamada H, Okuyama K, Sagawa T, Makinoda S, Fujimoto S
J Perinat Med 1997;25(1):71-7. doi: 10.1515/jpme.1997.25.1.71. PMID: 9085206

Prognosis

Hizem S, Elaribi Y, Ben Slama S, Dimassi K, Jilani H, Rejeb I, Sebaï M, Bekri S, Ben Jemaa L
Clin Chim Acta 2021 Feb;513:68-70. Epub 2020 Dec 29 doi: 10.1016/j.cca.2020.12.027. PMID: 33382994
Okeke TC, Egbugara MN, Ezenyeaku CC, Ikeako LC
Niger J Med 2013 Oct-Dec;22(4):266-73. PMID: 24283082
Désilets V, Audibert F; Society of Obstetrician and Gynaecologists of Canada
J Obstet Gynaecol Can 2013 Oct;35(10):923-38. doi: 10.1016/s1701-2163(15)30816-1. PMID: 24165062
Wraith JE
Semin Neonatol 2002 Feb;7(1):75-83. doi: 10.1053/siny.2001.0088. PMID: 12069540
Nelson J
Hum Genet 1997 Dec;101(3):355-8. doi: 10.1007/s004390050641. PMID: 9439667

Clinical prediction guides

Guo D, He S, Lin N, Dai Y, Li Y, Xu L, Wu X
BMC Med Genomics 2023 Apr 20;16(1):83. doi: 10.1186/s12920-023-01505-y. PMID: 37081464Free PMC Article
Smeland MF, Brouillard P, Prescott T, Boon LM, Hvingel B, Nordbakken CV, Nystad M, Holla ØL, Vikkula M
J Med Genet 2023 Jan;60(1):57-64. Epub 2021 Dec 7 doi: 10.1136/jmedgenet-2021-108179. PMID: 34876502Free PMC Article
Ghesh L, Besnard T, Joubert M, Picard V, Le Vaillant C, Beneteau C
Clin Genet 2022 Dec;102(6):543-547. Epub 2022 Sep 13 doi: 10.1111/cge.14217. PMID: 36031591
Giugliani R, Barth AL, Dumas MRC, da Silva Franco JF, de Rosso Giuliani L, Grangeiro CHP, Horovitz DDG, Kim CA, de Araújo Leão EKE, de Medeiros PFV, Miguel DSCG, Moreira MESA, Dos Santos HMGP, da Silva LCS, da Silva LR, de Souza IN, Nalin T, Garcia D
Orphanet J Rare Dis 2021 May 22;16(1):238. doi: 10.1186/s13023-021-01870-w. PMID: 34022924Free PMC Article
Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM
J Ultrasound Med 2018 May;37(5):1185-1191. Epub 2017 Oct 27 doi: 10.1002/jum.14462. PMID: 29076544Free PMC Article

Recent systematic reviews

Brewer CJ, Makhamreh MM, Shivashankar K, McLaren R, Toro M, Berger SI, Al-Kouatly HB
Prenat Diagn 2023 Nov;43(12):1556-1566. Epub 2023 Oct 30 doi: 10.1002/pd.6451. PMID: 37902181
Al-Kouatly HB, Shivashankar K, Mossayebi MH, Makhamreh M, Critchlow E, Gao Z, Fasehun LK, Alkuraya FS, Ryan EE, Hegde M, Wodoslawsky S, Hughes J, Berger SI
Clin Genet 2023 May;103(5):503-512. Epub 2023 Feb 26 doi: 10.1111/cge.14309. PMID: 36757664
Mone F, Eberhardt RY, Hurles ME, Mcmullan DJ, Maher ER, Lord J, Chitty LS, Dempsey E, Homfray T, Giordano JL, Wapner RJ, Sun L, Sparks TN, Norton ME, Kilby MD
Ultrasound Obstet Gynecol 2021 Oct;58(4):509-518. doi: 10.1002/uog.23652. PMID: 33847422Free PMC Article

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