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Increased urinary bile acid level

MedGen UID:
1053386
Concept ID:
CN377354
Finding
HPO: HP:6000523

Definition

The amount of bile acids in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Dekker SEI, Bierau J, Giera M, Blomberg N, Drenth JPH, Mayboroda OA, de Fijter JW, Soonawala D; DIPAK Consortium
Eur J Clin Invest 2024 Apr;54(4):e14147. Epub 2023 Dec 9 doi: 10.1111/eci.14147. PMID: 38071418
Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
Batta AK, Arora R, Salen G, Tint GS, Eskreis D, Katz S
J Lipid Res 1989 Dec;30(12):1953-62. PMID: 2621422

Recent clinical studies

Etiology

Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D
Gut 2020 Jul;69(7):1258-1268. Epub 2020 Feb 19 doi: 10.1136/gutjnl-2019-320438. PMID: 32075887Free PMC Article
Zhang MH, Setchell KD, Zhao J, Gong JY, Lu Y, Wang JS
World J Gastroenterol 2019 Feb 21;25(7):859-869. doi: 10.3748/wjg.v25.i7.859. PMID: 30809085Free PMC Article
Chabot GG
Clin Pharmacokinet 1997 Oct;33(4):245-59. doi: 10.2165/00003088-199733040-00001. PMID: 9342501
Strandvik B, Wahlén E, Wikström SA
Scand J Clin Lab Invest 1994 Feb;54(1):1-10. doi: 10.3109/00365519409086503. PMID: 8171265

Diagnosis

Wang WX, Chen L, Wang GY, Zhang JL, Tan XW, Lin QH, Chen YJ, Zhang J, Zhu PP, Miao J, Su MM, Liu CX, Jia W, Lan K
Drug Metab Dispos 2020 Aug;48(8):662-672. Epub 2020 Jun 4 doi: 10.1124/dmd.120.000011. PMID: 32499339
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D
Gut 2020 Jul;69(7):1258-1268. Epub 2020 Feb 19 doi: 10.1136/gutjnl-2019-320438. PMID: 32075887Free PMC Article
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Walters JR
Nat Rev Gastroenterol Hepatol 2014 Jul;11(7):426-34. Epub 2014 Mar 25 doi: 10.1038/nrgastro.2014.32. PMID: 24662279
Thuijls G, van Wijck K, Grootjans J, Derikx JP, van Bijnen AA, Heineman E, Dejong CH, Buurman WA, Poeze M
Ann Surg 2011 Feb;253(2):303-8. doi: 10.1097/SLA.0b013e318207a767. PMID: 21245670

Therapy

Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D
Gut 2020 Jul;69(7):1258-1268. Epub 2020 Feb 19 doi: 10.1136/gutjnl-2019-320438. PMID: 32075887Free PMC Article
Zhang MH, Setchell KD, Zhao J, Gong JY, Lu Y, Wang JS
World J Gastroenterol 2019 Feb 21;25(7):859-869. doi: 10.3748/wjg.v25.i7.859. PMID: 30809085Free PMC Article
Wang XX, Edelstein MH, Gafter U, Qiu L, Luo Y, Dobrinskikh E, Lucia S, Adorini L, D'Agati VD, Levi J, Rosenberg A, Kopp JB, Gius DR, Saleem MA, Levi M
J Am Soc Nephrol 2016 May;27(5):1362-78. Epub 2015 Sep 30 doi: 10.1681/ASN.2014121271. PMID: 26424786Free PMC Article
Chabot GG
Clin Pharmacokinet 1997 Oct;33(4):245-59. doi: 10.2165/00003088-199733040-00001. PMID: 9342501

Prognosis

Rojo-Sánchez A, Carmona-Martes A, Díaz-Olmos Y, Santamaría-Torres M, Cala MP, Orozco-Acosta E, Aroca-Martínez G, Pacheco-Londoño L, Navarro-Quiroz E, Pacheco-Lugo LA
Sci Rep 2024 Apr 25;14(1):9555. doi: 10.1038/s41598-024-60217-0. PMID: 38664528Free PMC Article
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Bajaj JS, Kakiyama G, Cox IJ, Nittono H, Takei H, White M, Fagan A, Gavis EA, Heuman DM, Gilles HC, Hylemon P, Taylor-Robinson SD, Legido-Quigley C, Kim M, Xu J, Williams R, Sikaroodi M, Pandak WM, Gillevet PM
Liver Transpl 2018 Jun;24(6):752-761. Epub 2018 May 13 doi: 10.1002/lt.25046. PMID: 29500907Free PMC Article
Berg UB, Németh A
J Pediatr Gastroenterol Nutr 2018 Apr;66(4):575-580. doi: 10.1097/MPG.0000000000001862. PMID: 29240010
El-Mir MY, Badia MD, Luengo N, Monte MJ, Marin JJ
Clin Sci (Lond) 2001 May;100(5):499-508. PMID: 11294690

Clinical prediction guides

Wang XX, Edelstein MH, Gafter U, Qiu L, Luo Y, Dobrinskikh E, Lucia S, Adorini L, D'Agati VD, Levi J, Rosenberg A, Kopp JB, Gius DR, Saleem MA, Levi M
J Am Soc Nephrol 2016 May;27(5):1362-78. Epub 2015 Sep 30 doi: 10.1681/ASN.2014121271. PMID: 26424786Free PMC Article
Chu L, Zhang K, Zhang Y, Jin X, Jiang H
Int Urol Nephrol 2015 Feb;47(2):345-51. Epub 2014 Dec 25 doi: 10.1007/s11255-014-0901-0. PMID: 25539619
Chabot GG
Clin Pharmacokinet 1997 Oct;33(4):245-59. doi: 10.2165/00003088-199733040-00001. PMID: 9342501
Nakashima M, Umemura K
Blood Press Suppl 1996;2:62-6. PMID: 8913542
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Recent systematic reviews

Botero Aguirre JP, Restrepo Hamid AM
Cochrane Database Syst Rev 2015 Nov 23;2015(11):CD010481. doi: 10.1002/14651858.CD010481.pub2. PMID: 26595825Free PMC Article

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