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Aqueous humor viral DNA positivity

MedGen UID:
1053425
•Concept ID:
CN376449
•
Finding
HPO: HP:0430031

Definition

The presence of viral DNA (e.g., cytomegalovirus, herpes simplex virus, or varicella zoster virus) in the aqueous humor of the eye. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAqueous humor viral DNA positivity

Professional guidelines

PubMed

Cytomegalovirus Anterior Uveitis: Clinical Manifestations, Diagnosis, Treatment, and Immunological Mechanisms.
Zhang J, Kamoi K, Zong Y, Yang M, Ohno-Matsui K
Viruses 2023 Jan 9;15(1) doi: 10.3390/v15010185. PMID: 36680225Free PMC Article
Classification Criteria for Cytomegalovirus Anterior Uveitis.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:89-95. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.060. PMID: 33845019Free PMC Article
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044

Recent clinical studies

Etiology

Cytomegalovirus Anterior Uveitis: Clinical Manifestations, Diagnosis, Treatment, and Immunological Mechanisms.
Zhang J, Kamoi K, Zong Y, Yang M, Ohno-Matsui K
Viruses 2023 Jan 9;15(1) doi: 10.3390/v15010185. PMID: 36680225Free PMC Article
Classification Criteria for Cytomegalovirus Anterior Uveitis.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:89-95. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.060. PMID: 33845019Free PMC Article
Causes of Hypertensive Anterior Uveitis in Thailand.
Khieu C, Kongyai N, Pathanapitoon K, Van Der Eijk AA, Rothova A
Ocul Immunol Inflamm 2020 May 18;28(4):559-565. Epub 2019 Nov 7 doi: 10.1080/09273948.2019.1678651. PMID: 31697590
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044
Association of cytomegalovirus with idiopathic chronic anterior uveitis with ocular hypertension in Korean patients.
Park SW, Yu HG
Ocul Immunol Inflamm 2013 Jun;21(3):192-6. Epub 2013 Mar 12 doi: 10.3109/09273948.2012.754908. PMID: 23480606

Diagnosis

Cytomegalovirus Anterior Uveitis: Clinical Manifestations, Diagnosis, Treatment, and Immunological Mechanisms.
Zhang J, Kamoi K, Zong Y, Yang M, Ohno-Matsui K
Viruses 2023 Jan 9;15(1) doi: 10.3390/v15010185. PMID: 36680225Free PMC Article
Usefulness of aqueous and vitreous humor analysis in infectious uveitis.
Santos HNVD, Ferracioli-Oda E, Barbosa TS, Otani CSV, Tanaka T, Silva LCSD, Lopes GO, Doi A, Hirata CE, Yamamoto JH
Clinics (Sao Paulo) 2020;75:e1498. Epub 2020 Jan 24 doi: 10.6061/clinics/2020/e1498. PMID: 31994615Free PMC Article
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044
Association of cytomegalovirus with idiopathic chronic anterior uveitis with ocular hypertension in Korean patients.
Park SW, Yu HG
Ocul Immunol Inflamm 2013 Jun;21(3):192-6. Epub 2013 Mar 12 doi: 10.3109/09273948.2012.754908. PMID: 23480606
Testing ocular fluids in uveitis.
Bodaghi B, LeHoang P
Ophthalmol Clin North Am 2002 Sep;15(3):271-9. doi: 10.1016/s0896-1549(02)00037-8. PMID: 12434476

Therapy

Cytomegalovirus Anterior Uveitis: Clinical Manifestations, Diagnosis, Treatment, and Immunological Mechanisms.
Zhang J, Kamoi K, Zong Y, Yang M, Ohno-Matsui K
Viruses 2023 Jan 9;15(1) doi: 10.3390/v15010185. PMID: 36680225Free PMC Article
Prognostic Factors of Cytomegalovirus Infection Associated Retinitis in HIV-Negative Patients: A Retrospective Cohort Study.
Qian Z, Chen X, Tao Y, Li W, Gu W
Ocul Immunol Inflamm 2021 Jan 2;29(1):154-159. Epub 2019 Oct 3 doi: 10.1080/09273948.2019.1659978. PMID: 31580185
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
Schoenberger SD, Kim SJ, Thorne JE, Mruthyunjaya P, Yeh S, Bakri SJ, Ehlers JP
Ophthalmology 2017 Mar;124(3):382-392. Epub 2017 Jan 13 doi: 10.1016/j.ophtha.2016.11.007. PMID: 28094044
Aqueous humor immune factors and cytomegalovirus (CMV) levels in CMV retinitis through treatment - The CRIGSS study.
Iyer JV, Agrawal R, Yeo TK, Gunasekeran DV, Balne PK, Lee B, Au VB, Connolly J, Teoh SC
Cytokine 2016 Aug;84:56-62. Epub 2016 May 27 doi: 10.1016/j.cyto.2016.05.009. PMID: 27239802
Progressive herpetic linear endotheliitis.
Shen YC, Wang CY, Chen YC, Lee YF
Cornea 2007 Apr;26(3):365-7. doi: 10.1097/ICO.0b013e31802c9e49. PMID: 17413967

Prognosis

Cytomegalovirus Anterior Uveitis: Clinical Manifestations, Diagnosis, Treatment, and Immunological Mechanisms.
Zhang J, Kamoi K, Zong Y, Yang M, Ohno-Matsui K
Viruses 2023 Jan 9;15(1) doi: 10.3390/v15010185. PMID: 36680225Free PMC Article
Prognostic Factors of Cytomegalovirus Infection Associated Retinitis in HIV-Negative Patients: A Retrospective Cohort Study.
Qian Z, Chen X, Tao Y, Li W, Gu W
Ocul Immunol Inflamm 2021 Jan 2;29(1):154-159. Epub 2019 Oct 3 doi: 10.1080/09273948.2019.1659978. PMID: 31580185
Causes of Hypertensive Anterior Uveitis in Thailand.
Khieu C, Kongyai N, Pathanapitoon K, Van Der Eijk AA, Rothova A
Ocul Immunol Inflamm 2020 May 18;28(4):559-565. Epub 2019 Nov 7 doi: 10.1080/09273948.2019.1678651. PMID: 31697590
Aqueous humor immune factors and cytomegalovirus (CMV) levels in CMV retinitis through treatment - The CRIGSS study.
Iyer JV, Agrawal R, Yeo TK, Gunasekeran DV, Balne PK, Lee B, Au VB, Connolly J, Teoh SC
Cytokine 2016 Aug;84:56-62. Epub 2016 May 27 doi: 10.1016/j.cyto.2016.05.009. PMID: 27239802
Association of cytomegalovirus with idiopathic chronic anterior uveitis with ocular hypertension in Korean patients.
Park SW, Yu HG
Ocul Immunol Inflamm 2013 Jun;21(3):192-6. Epub 2013 Mar 12 doi: 10.3109/09273948.2012.754908. PMID: 23480606

Clinical prediction guides

Iris depigmentation and cytomegalovirus in aqueous humor as predictors of uveitic activity and recurrence in chronic and recurrent anterior uveitis.
Kam KW, Mok E, Ho M, Wong CH, Sze RKH, Chan PK, Young AL
Indian J Ophthalmol 2023 Dec 1;71(12):3684-3689. Epub 2023 Nov 20 doi: 10.4103/IJO.IJO_2937_22. PMID: 37991304Free PMC Article
Polymorphisms of the cytomegalovirus glycoprotein B genotype in patients with Posner-Schlossman syndrome.
Zhai R, Wang Z, Sheng Q, Fan X, Kong X, Sun X
Br J Ophthalmol 2022 Sep;106(9):1240-1244. Epub 2021 Mar 22 doi: 10.1136/bjophthalmol-2020-318284. PMID: 33753409Free PMC Article
Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients.
Leleu I, Jhanji V, Touhami S, Westcott M, Angi M, Titah C, Rousseau A, Hamard P, Brasnu E, Manicom T, Blumen-Ohana E, Rozenberg F, Vauloup-Fellous C, Deback C, Labetoulle M, Sahel JA, Bodaghi B, Merabet L, Kobal A, Brignole-Baudouin F, Errera MH
Ocul Immunol Inflamm 2021 Jan 2;29(1):160-168. Epub 2019 Oct 23 doi: 10.1080/09273948.2019.1662059. PMID: 31642720
Relationships between the clinical characteristics and copy numbers of DNA of cytomegalovirus determined by real-time PCR.
Yoshimura A, Araki-Sasaki K, Toyokawa N, Fujiwara R, Jho N, Gomi F
Int Ophthalmol 2020 Sep;40(9):2297-2305. Epub 2020 May 16 doi: 10.1007/s10792-020-01412-6. PMID: 32418075Free PMC Article
Detection of herpesvirus DNA in vitreous and aqueous specimens by the polymerase chain reaction.
Fox GM, Crouse CA, Chuang EL, Pflugfelder SC, Cleary TJ, Nelson SJ, Atherton SS
Arch Ophthalmol 1991 Feb;109(2):266-71. doi: 10.1001/archopht.1991.01080020112054. PMID: 1847043

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