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Gastric carcinoid tumor

MedGen UID:
1053427
•Concept ID:
CN378250
•
Finding
HPO: HP:6000898

Definition

Originating from enterochromaffin-like cells, gastric carcinoid tumors are rare tumors that develop within the gastric mucosa. They can present as an isolated lesion or there can be multiple lesions. The tumor can invade locally into deeper structures of the gastrointestinal tract wall. Solitary gastric carcinoids have a greater chance for the development of malignancy and metastasis as compared to multiple gastric carcinoids due to hypergastrinemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric carcinoid tumor

Professional guidelines

PubMed

Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999

Recent clinical studies

Etiology

Solitary Gastric Carcinoid Tumor Associated with Long-Term Use of Omeprazole: A Case Report and Review of the Literature.
Nandy N, Hanson JA, Strickland RG, McCarthy DM
Dig Dis Sci 2016 Mar;61(3):708-12. Epub 2015 Dec 29 doi: 10.1007/s10620-015-4014-0. PMID: 26715503
Gastric carcinoid tumor after laparoscopic sleeve gastrectomy.
Erim T, Colak Y, Szomstein S
Surg Obes Relat Dis 2015 Nov-Dec;11(6):e51-2. Epub 2015 Jun 25 doi: 10.1016/j.soard.2015.06.016. PMID: 26507937
Proton pump inhibitors: potential adverse effects.
Abraham NS
Curr Opin Gastroenterol 2012 Nov;28(6):615-20. doi: 10.1097/MOG.0b013e328358d5b9. PMID: 23010681
Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999
Multifocal gastric carcinoid tumor in a patient with pernicious anemia receiving lansoprazole.
Attila T, Santharam R, Blom D, Komorowski R, Koch TR
Dig Dis Sci 2005 Mar;50(3):509-13. doi: 10.1007/s10620-005-2466-3. PMID: 15810634

Diagnosis

Gastric carcinoid tumor after laparoscopic sleeve gastrectomy.
Erim T, Colak Y, Szomstein S
Surg Obes Relat Dis 2015 Nov-Dec;11(6):e51-2. Epub 2015 Jun 25 doi: 10.1016/j.soard.2015.06.016. PMID: 26507937
Gastric carcinoid tumor in a 14-year old girl.
Kirsaclioglu CT, Kuloglu Z, Kansu A, Ensari A, Siklar Z, Berberoğlu M, Ocal G
Scand J Gastroenterol 2014 Nov;49(11):1391-3. Epub 2014 Sep 2 doi: 10.3109/00365521.2014.953574. PMID: 25180819
Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999
Gastric carcinoid tumor.
Mermuys K, Van Hoe L, Vanhoenacker PR
JBR-BTR 2007 Mar-Apr;90(2):137. PMID: 17555079
A gastric carcinoid tumor with massive bleeding.
Honig LJ, Weingarten G
Am J Gastroenterol 1974 Jan;61(1):40-4. PMID: 4544767

Therapy

Solitary Gastric Carcinoid Tumor Associated with Long-Term Use of Omeprazole: A Case Report and Review of the Literature.
Nandy N, Hanson JA, Strickland RG, McCarthy DM
Dig Dis Sci 2016 Mar;61(3):708-12. Epub 2015 Dec 29 doi: 10.1007/s10620-015-4014-0. PMID: 26715503
Gastric carcinoid tumor after laparoscopic sleeve gastrectomy.
Erim T, Colak Y, Szomstein S
Surg Obes Relat Dis 2015 Nov-Dec;11(6):e51-2. Epub 2015 Jun 25 doi: 10.1016/j.soard.2015.06.016. PMID: 26507937
Proton pump inhibitors: potential adverse effects.
Abraham NS
Curr Opin Gastroenterol 2012 Nov;28(6):615-20. doi: 10.1097/MOG.0b013e328358d5b9. PMID: 23010681
Multifocal gastric carcinoid tumor in a patient with pernicious anemia receiving lansoprazole.
Attila T, Santharam R, Blom D, Komorowski R, Koch TR
Dig Dis Sci 2005 Mar;50(3):509-13. doi: 10.1007/s10620-005-2466-3. PMID: 15810634
Multimodality treatment for gastric carcinoid tumor with liver metastases.
Caplin ME, Hodgson HJ, Dhillon AP, Begent R, Buscombe J, Dick R, Rolles K, Burroughs AK
Am J Gastroenterol 1998 Oct;93(10):1945-8. doi: 10.1111/j.1572-0241.1998.00551.x. PMID: 9772061

Prognosis

Gastric carcinoid tumor after laparoscopic sleeve gastrectomy.
Erim T, Colak Y, Szomstein S
Surg Obes Relat Dis 2015 Nov-Dec;11(6):e51-2. Epub 2015 Jun 25 doi: 10.1016/j.soard.2015.06.016. PMID: 26507937
Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor.
Zhang L, Ozao J, Warner R, Divino C
World J Surg 2011 Aug;35(8):1879-86. doi: 10.1007/s00268-011-1137-0. PMID: 21559999
Multifocal gastric carcinoid tumor in a patient with pernicious anemia receiving lansoprazole.
Attila T, Santharam R, Blom D, Komorowski R, Koch TR
Dig Dis Sci 2005 Mar;50(3):509-13. doi: 10.1007/s10620-005-2466-3. PMID: 15810634
Carcinoid tumors of the stomach.
Modlin IM, Lye KD, Kidd M
Surg Oncol 2003 Aug;12(2):153-72. doi: 10.1016/s0960-7404(03)00034-3. PMID: 12946486
Gastric carcinoid tumors: the biology and therapy of an enigmatic and controversial lesion.
Gilligan CJ, Lawton GP, Tang LH, West AB, Modlin IM
Am J Gastroenterol 1995 Mar;90(3):338-52. PMID: 7872269

Clinical prediction guides

The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors.
Tüzün A, Keskin O, Yakut M, Kalkan C, Soykan I
Platelets 2014;25(5):363-6. Epub 2013 Oct 31 doi: 10.3109/09537104.2013.821607. PMID: 24175991
Proton pump inhibitors: potential adverse effects.
Abraham NS
Curr Opin Gastroenterol 2012 Nov;28(6):615-20. doi: 10.1097/MOG.0b013e328358d5b9. PMID: 23010681
Minimally invasive surgery for gastric carcinoid tumor.
Otani Y, Furukawa T, Suganuma K, Yoshida M, Saikawa Y, Kubota T, Kumai K, Mukai M, Kameyama K, Takami H, Kitajima M
Biomed Pharmacother 2002;56 Suppl 1:217s-221s. doi: 10.1016/s0753-3322(02)00282-2. PMID: 12487286
Gastric carcinoid tumors without autoimmune gastritis in Japan: a relationship with Helicobacter pylori infection.
Sato Y, Iwafuchi M, Ueki J, Yoshimura A, Mochizuki T, Motoyama H, Sugimura K, Honma T, Narisawa R, Ichida T, Asakura H, Van Thiel DH
Dig Dis Sci 2002 Mar;47(3):579-85. doi: 10.1023/a:1017972204219. PMID: 11911346
Octreotide suppression test predicts beneficial outcome from antrectomy in a patient with gastric carcinoid tumor.
Higham AD, Dimaline R, Varro A, Attwood S, Armstrong G, Dockray GJ, Thompson DG
Gastroenterology 1998 Apr;114(4):817-22. doi: 10.1016/s0016-5085(98)70596-7. PMID: 9516403

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