U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anti-ADAMTS13 antibody positivity

MedGen UID:
1053501
Concept ID:
CN377294
Finding
HPO: HP:6000462

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats, member 13 (ADAMTS13). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-ADAMTS13 antibody positivity

Professional guidelines

PubMed

Matsumoto M, Miyakawa Y, Kokame K, Ueda Y, Wada H, Higasa S, Yagi H, Ogawa Y, Sakai K, Miyata T, Morishita E, Fujimura Y; For TTP group of Blood Coagulation Abnormalities Research Study Team, Research on Rare and Intractable diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan
Int J Hematol 2023 Nov;118(5):529-546. Epub 2023 Sep 10 doi: 10.1007/s12185-023-03657-0. PMID: 37689812Free PMC Article
Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M; For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants
Int J Hematol 2017 Jul;106(1):3-15. Epub 2017 May 26 doi: 10.1007/s12185-017-2264-7. PMID: 28550351

Recent clinical studies

Etiology

Matsumoto M, Miyakawa Y, Kokame K, Ueda Y, Wada H, Higasa S, Yagi H, Ogawa Y, Sakai K, Miyata T, Morishita E, Fujimura Y; For TTP group of Blood Coagulation Abnormalities Research Study Team, Research on Rare and Intractable diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan
Int J Hematol 2023 Nov;118(5):529-546. Epub 2023 Sep 10 doi: 10.1007/s12185-023-03657-0. PMID: 37689812Free PMC Article
Sakai K, Matsumoto M, De Waele L, Dekimpe C, Hamada E, Kubo M, Tersteeg C, De Meyer SF, Vanhoorelbeke K
Blood Adv 2023 Jan 10;7(1):131-140. doi: 10.1182/bloodadvances.2022008885. PMID: 36306339Free PMC Article
Yun J, Gu J, Kim HK
J Thromb Thrombolysis 2021 Nov;52(4):1133-1136. Epub 2021 Apr 29 doi: 10.1007/s11239-021-02406-6. PMID: 33914240
Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M; For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants
Int J Hematol 2017 Jul;106(1):3-15. Epub 2017 May 26 doi: 10.1007/s12185-017-2264-7. PMID: 28550351
Zanato V, Lombardi AM, Busetto L, Prà CD, Foletto M, Prevedello L, De Marinis GB, Fabris F, Vettor R, Fabris R
Endocrine 2017 Jun;56(3):521-527. Epub 2016 Aug 16 doi: 10.1007/s12020-016-1059-6. PMID: 27530508

Diagnosis

Matsumoto M, Miyakawa Y, Kokame K, Ueda Y, Wada H, Higasa S, Yagi H, Ogawa Y, Sakai K, Miyata T, Morishita E, Fujimura Y; For TTP group of Blood Coagulation Abnormalities Research Study Team, Research on Rare and Intractable diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan
Int J Hematol 2023 Nov;118(5):529-546. Epub 2023 Sep 10 doi: 10.1007/s12185-023-03657-0. PMID: 37689812Free PMC Article
Sakai K, Matsumoto M, De Waele L, Dekimpe C, Hamada E, Kubo M, Tersteeg C, De Meyer SF, Vanhoorelbeke K
Blood Adv 2023 Jan 10;7(1):131-140. doi: 10.1182/bloodadvances.2022008885. PMID: 36306339Free PMC Article
Nazy I, Jevtic SD, Moore JC, Huynh A, Smith JW, Kelton JG, Arnold DM
J Thromb Haemost 2021 May;19(5):1342-1347. Epub 2021 Mar 14 doi: 10.1111/jth.15283. PMID: 33639037Free PMC Article
Schelpe AS, Roose E, Joly BS, Pareyn I, Mancini I, Biganzoli M, Deckmyn H, Voorberg J, Fijnheer R, Peyvandi F, De Meyer SF, Coppo P, Veyradier A, Vanhoorelbeke K
Haematologica 2019 Jun;104(6):1268-1276. Epub 2018 Dec 6 doi: 10.3324/haematol.2018.205666. PMID: 30523052Free PMC Article
Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M; For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants
Int J Hematol 2017 Jul;106(1):3-15. Epub 2017 May 26 doi: 10.1007/s12185-017-2264-7. PMID: 28550351

Therapy

Nazy I, Jevtic SD, Moore JC, Huynh A, Smith JW, Kelton JG, Arnold DM
J Thromb Haemost 2021 May;19(5):1342-1347. Epub 2021 Mar 14 doi: 10.1111/jth.15283. PMID: 33639037Free PMC Article
Caeiro Alves F, Aguiar R, Pessegueiro P, Pires C
BMJ Case Rep 2018 Mar 17;2018 doi: 10.1136/bcr-2017-222582. PMID: 29550758Free PMC Article
Joly BS, Stepanian A, Leblanc T, Hajage D, Chambost H, Harambat J, Fouyssac F, Guigonis V, Leverger G, Ulinski T, Kwon T, Loirat C, Coppo P, Veyradier A; French Reference Center for Thrombotic Microangiopathies
Lancet Haematol 2016 Nov;3(11):e537-e546. Epub 2016 Oct 3 doi: 10.1016/S2352-3026(16)30125-9. PMID: 27720178
Iioka F, Shimomura D, Ishii T, Maesako Y, Ohgoe K, Nakamura F, Matsuo S, Ohno H
Int J Hematol 2012 Oct;96(4):506-12. Epub 2012 Aug 10 doi: 10.1007/s12185-012-1162-2. PMID: 22878941
Sevy A, Doche E, Squarcioni C, Poullin P, Serratrice J, Nicoli F, Weiller PJ
J Clin Apher 2011;26(3):152-5. Epub 2010 Dec 13 doi: 10.1002/jca.20276. PMID: 21647953

Prognosis

Schelpe AS, Roose E, Joly BS, Pareyn I, Mancini I, Biganzoli M, Deckmyn H, Voorberg J, Fijnheer R, Peyvandi F, De Meyer SF, Coppo P, Veyradier A, Vanhoorelbeke K
Haematologica 2019 Jun;104(6):1268-1276. Epub 2018 Dec 6 doi: 10.3324/haematol.2018.205666. PMID: 30523052Free PMC Article
Mancini I, Ferrari B, Valsecchi C, Pontiggia S, Fornili M, Biganzoli E, Peyvandi F; Italian Group of TTP Investigators
Eur J Intern Med 2017 Apr;39:79-83. Epub 2016 Nov 22 doi: 10.1016/j.ejim.2016.11.003. PMID: 27887777
Zanato V, Lombardi AM, Busetto L, Prà CD, Foletto M, Prevedello L, De Marinis GB, Fabris F, Vettor R, Fabris R
Endocrine 2017 Jun;56(3):521-527. Epub 2016 Aug 16 doi: 10.1007/s12020-016-1059-6. PMID: 27530508
Mai Falk J, Scharrer I
Transfusion 2016 Nov;56(11):2819-2823. Epub 2016 Aug 11 doi: 10.1111/trf.13751. PMID: 27514869
Li D, Xiao J, Paessler M, Zheng XL
Thromb Haemost 2011 Nov;106(5):947-58. Epub 2011 Sep 8 doi: 10.1160/TH11-05-0337. PMID: 21901237Free PMC Article

Clinical prediction guides

Sakai K, Matsumoto M, De Waele L, Dekimpe C, Hamada E, Kubo M, Tersteeg C, De Meyer SF, Vanhoorelbeke K
Blood Adv 2023 Jan 10;7(1):131-140. doi: 10.1182/bloodadvances.2022008885. PMID: 36306339Free PMC Article
Zanato V, Lombardi AM, Busetto L, Prà CD, Foletto M, Prevedello L, De Marinis GB, Fabris F, Vettor R, Fabris R
Endocrine 2017 Jun;56(3):521-527. Epub 2016 Aug 16 doi: 10.1007/s12020-016-1059-6. PMID: 27530508
Mai Falk J, Scharrer I
Transfusion 2016 Nov;56(11):2819-2823. Epub 2016 Aug 11 doi: 10.1111/trf.13751. PMID: 27514869
Huang H, Sun W, Liang Y, Long XD, Peng Y, Liu Z, Wen X, Jia M
Ren Fail 2014 Sep;36(8):1263-7. Epub 2014 Jul 3 doi: 10.3109/0886022X.2014.934649. PMID: 24990576
Li D, Xiao J, Paessler M, Zheng XL
Thromb Haemost 2011 Nov;106(5):947-58. Epub 2011 Sep 8 doi: 10.1160/TH11-05-0337. PMID: 21901237Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...