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Elevated urine fructose level

MedGen UID:
1053583
•Concept ID:
CN377953
•
Finding
HPO: HP:6000804

Definition

Amount of fructose in the urine above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urine fructose level

Conditions with this feature

Essential fructosuria
MedGen UID:
78645
•Concept ID:
C0268160
•
Disease or Syndrome
Essential fructosuria is a benign, asymptomatic defect of intermediary metabolism characterized by the intermittent appearance of fructose in the urine (summary by Bonthron et al., 1994).
See: Condition Record
Essential fructosuria

Recent clinical studies

Etiology

Enhanced renoprotective actions of Paricalcitol and omega-3 fatty acids co-therapy against diabetic nephropathy in rat.
El-Boshy M, Alsaegh A, Qasem AH, Sindi RA, Abdelghany AH, Gadalla H, Reda D, Azzeh F, Idris S, Ahmad J, Refaat B
J Adv Res 2022 May;38:119-129. Epub 2021 Aug 18 doi: 10.1016/j.jare.2021.08.010. PMID: 35572411Free PMC Article
Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Sharma R, Kumari M, Prakash P, Gupta S, Tiwari S
Am J Physiol Renal Physiol 2020 Mar 1;318(3):F720-F731. Epub 2020 Feb 10 doi: 10.1152/ajprenal.00507.2019. PMID: 32036699
d-Glycerate kinase deficiency in a neuropediatric patient.
Sass JO, Behringer S, Fernando M, Cesaroni E, Cursio I, Volpini A, Till C
Brain Dev 2020 Feb;42(2):226-230. Epub 2019 Dec 11 doi: 10.1016/j.braindev.2019.11.008. PMID: 31837836
Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria.
Zhang LH, Zhu XY, Eirin A, Nargesi AA, Woollard JR, Santelli A, Sun IO, Textor SC, Lerman LO
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F12-F22. Epub 2019 May 1 doi: 10.1152/ajprenal.00399.2018. PMID: 31042059Free PMC Article
Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence.
Xia B, Zhu Q, Zhao Y, Ge W, Zhao Y, Song Q, Zhou Y, Shi H, Zhang Y
Environ Int 2018 Dec;121(Pt 1):159-168. Epub 2018 Sep 9 doi: 10.1016/j.envint.2018.09.001. PMID: 30208345

Diagnosis

Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Sharma R, Kumari M, Prakash P, Gupta S, Tiwari S
Am J Physiol Renal Physiol 2020 Mar 1;318(3):F720-F731. Epub 2020 Feb 10 doi: 10.1152/ajprenal.00507.2019. PMID: 32036699
d-Glycerate kinase deficiency in a neuropediatric patient.
Sass JO, Behringer S, Fernando M, Cesaroni E, Cursio I, Volpini A, Till C
Brain Dev 2020 Feb;42(2):226-230. Epub 2019 Dec 11 doi: 10.1016/j.braindev.2019.11.008. PMID: 31837836
DHEA-induced modulation of renal gluconeogenesis, insulin sensitivity and plasma lipid profile in the control- and dexamethasone-treated rabbits. Metabolic studies.
Kiersztan A, Nagalski A, Nalepa P, Tempes A, Trojan N, Usarek M, Jagielski AK
Biochimie 2016 Feb;121:87-101. Epub 2015 Nov 23 doi: 10.1016/j.biochi.2015.11.019. PMID: 26616007
Gastrointestinal Symptoms and Altered Intestinal Permeability Induced by Combat Training Are Associated with Distinct Metabotypic Changes.
Phua LC, Wilder-Smith CH, Tan YM, Gopalakrishnan T, Wong RK, Li X, Kan ME, Lu J, Keshavarzian A, Chan EC
J Proteome Res 2015 Nov 6;14(11):4734-42. Epub 2015 Oct 27 doi: 10.1021/acs.jproteome.5b00603. PMID: 26506213
Oral fructose absorption in obese children with non-alcoholic fatty liver disease.
Sullivan JS, Le MT, Pan Z, Rivard C, Love-Osborne K, Robbins K, Johnson RJ, Sokol RJ, Sundaram SS
Pediatr Obes 2015 Jun;10(3):188-95. Epub 2014 Jun 24 doi: 10.1111/ijpo.238. PMID: 24961681Free PMC Article

Therapy

Enhanced renoprotective actions of Paricalcitol and omega-3 fatty acids co-therapy against diabetic nephropathy in rat.
El-Boshy M, Alsaegh A, Qasem AH, Sindi RA, Abdelghany AH, Gadalla H, Reda D, Azzeh F, Idris S, Ahmad J, Refaat B
J Adv Res 2022 May;38:119-129. Epub 2021 Aug 18 doi: 10.1016/j.jare.2021.08.010. PMID: 35572411Free PMC Article
Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria.
Zhang LH, Zhu XY, Eirin A, Nargesi AA, Woollard JR, Santelli A, Sun IO, Textor SC, Lerman LO
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F12-F22. Epub 2019 May 1 doi: 10.1152/ajprenal.00399.2018. PMID: 31042059Free PMC Article
Effects of 1,5-anhydroglucitol on postprandial blood glucose and insulin levels and hydrogen excretion in rats and healthy humans.
Nakamura S, Tanabe K, Yoshinaga K, Shimura F, Oku T
Br J Nutr 2017 Jul;118(2):81-91. doi: 10.1017/S0007114517001866. PMID: 28820081
The metabolism of carbohydrates and lipid peroxidation in lead-exposed workers.
Kasperczyk A, Dobrakowski M, Ostałowska A, Zalejska-Fiolka J, Birkner E
Toxicol Ind Health 2015 Dec;31(12):1318-24. Epub 2013 Jul 5 doi: 10.1177/0748233713483204. PMID: 23833244
beta-Hydroxybutyrate decreases adenosine triphosphate degradation products in human subjects.
Lestan B, Walden K, Schmaltz S, Spychala J, Fox IH
J Lab Clin Med 1994 Aug;124(2):199-209. PMID: 8051483

Prognosis

Oral fructose absorption in obese children with non-alcoholic fatty liver disease.
Sullivan JS, Le MT, Pan Z, Rivard C, Love-Osborne K, Robbins K, Johnson RJ, Sokol RJ, Sundaram SS
Pediatr Obes 2015 Jun;10(3):188-95. Epub 2014 Jun 24 doi: 10.1111/ijpo.238. PMID: 24961681Free PMC Article
Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats.
Zhao CX, Xu X, Cui Y, Wang P, Wei X, Yang S, Edin ML, Zeldin DC, Wang DW
J Pharmacol Exp Ther 2009 Feb;328(2):610-20. Epub 2008 Nov 13 doi: 10.1124/jpet.108.143396. PMID: 19008412Free PMC Article
Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy.
Koschinsky T, He CJ, Mitsuhashi T, Bucala R, Liu C, Buenting C, Heitmann K, Vlassara H
Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6474-9. doi: 10.1073/pnas.94.12.6474. PMID: 9177242Free PMC Article

Clinical prediction guides

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria.
Zhang LH, Zhu XY, Eirin A, Nargesi AA, Woollard JR, Santelli A, Sun IO, Textor SC, Lerman LO
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F12-F22. Epub 2019 May 1 doi: 10.1152/ajprenal.00399.2018. PMID: 31042059Free PMC Article
Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence.
Xia B, Zhu Q, Zhao Y, Ge W, Zhao Y, Song Q, Zhou Y, Shi H, Zhang Y
Environ Int 2018 Dec;121(Pt 1):159-168. Epub 2018 Sep 9 doi: 10.1016/j.envint.2018.09.001. PMID: 30208345
Perspective: The Paradox in Dietary Advanced Glycation End Products Research-The Source of the Serum and Urinary Advanced Glycation End Products Is the Intestines, Not the Food.
DeChristopher LR
Adv Nutr 2017 Sep;8(5):679-683. Epub 2017 Sep 15 doi: 10.3945/an.117.016154. PMID: 28916568Free PMC Article
Hyponatremia with Persistent Elevated Urinary Fractional Uric Acid Excretion: Evidence for Proximal Tubular Injury?
Lee SK, Lanaspa MA, Sánchez-Lozada LG, Johnson RJ
Kidney Blood Press Res 2016;41(5):535-544. Epub 2016 Aug 26 doi: 10.1159/000447928. PMID: 27561821
Oral fructose absorption in obese children with non-alcoholic fatty liver disease.
Sullivan JS, Le MT, Pan Z, Rivard C, Love-Osborne K, Robbins K, Johnson RJ, Sokol RJ, Sundaram SS
Pediatr Obes 2015 Jun;10(3):188-95. Epub 2014 Jun 24 doi: 10.1111/ijpo.238. PMID: 24961681Free PMC Article

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