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Decreased urine creatinine level

MedGen UID:
1053968
•Concept ID:
CN376625
•
Finding
HPO: HP:6000115

Definition

The amount of creatinine in the urine, normalized for urine concentration, is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urine creatinine level

Professional guidelines

PubMed

Acute kidney injury, its definition, and treatment in adults: guidelines and reality.
Matuszkiewicz-Rowińska J, Małyszko J
Pol Arch Intern Med 2020 Dec 22;130(12):1074-1080. Epub 2020 May 19 doi: 10.20452/pamw.15373. PMID: 32426960
Diabetic Kidney Disease: Diagnosis, Treatment, and Prevention.
McGrath K, Edi R
Am Fam Physician 2019 Jun 15;99(12):751-759. PMID: 31194487
National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification.
Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G; National Kidney Foundation
Ann Intern Med 2003 Jul 15;139(2):137-47. doi: 10.7326/0003-4819-139-2-200307150-00013. PMID: 12859163

Recent clinical studies

Etiology

A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy.
Lafayette R, Barbour S, Israni R, Wei X, Eren N, Floege J, Jha V, Kim SG, Maes B, Phoon RKS, Singh H, Tesař V, Lin CJF, Barratt J
Kidney Int 2024 Jun;105(6):1306-1315. Epub 2024 Mar 27 doi: 10.1016/j.kint.2024.03.012. PMID: 38552841
Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance.
Wang L, Xu X, Zhang M, Hu C, Zhang X, Li C, Nie S, Huang Z, Zhao Z, Hou FF, Zhou M
JAMA Intern Med 2023 Apr 1;183(4):298-310. doi: 10.1001/jamainternmed.2022.6817. PMID: 36804760Free PMC Article
Acute kidney injury, its definition, and treatment in adults: guidelines and reality.
Matuszkiewicz-Rowińska J, Małyszko J
Pol Arch Intern Med 2020 Dec 22;130(12):1074-1080. Epub 2020 May 19 doi: 10.20452/pamw.15373. PMID: 32426960
Subclinical AKI: ready for primetime in clinical practice?
Vanmassenhove J, Van Biesen W, Vanholder R, Lameire N
J Nephrol 2019 Feb;32(1):9-16. Epub 2018 Dec 6 doi: 10.1007/s40620-018-00566-y. PMID: 30523562
Post-partum podocyturia following pre-eclamptic pregnancy.
Furuta I, Zhai T, Umazume T, Ishikawa S, Hosokawa A, Kojima T, Chiba K, Yamada T, Morikawa M, Minakami H
J Obstet Gynaecol Res 2017 Jun;43(6):1008-1013. doi: 10.1111/jog.13326. PMID: 28621045

Diagnosis

A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy.
Lafayette R, Barbour S, Israni R, Wei X, Eren N, Floege J, Jha V, Kim SG, Maes B, Phoon RKS, Singh H, Tesař V, Lin CJF, Barratt J
Kidney Int 2024 Jun;105(6):1306-1315. Epub 2024 Mar 27 doi: 10.1016/j.kint.2024.03.012. PMID: 38552841
Acute kidney injury, its definition, and treatment in adults: guidelines and reality.
Matuszkiewicz-Rowińska J, Małyszko J
Pol Arch Intern Med 2020 Dec 22;130(12):1074-1080. Epub 2020 May 19 doi: 10.20452/pamw.15373. PMID: 32426960
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364
How to use… serum creatinine, cystatin C and GFR.
Pasala S, Carmody JB
Arch Dis Child Educ Pract Ed 2017 Feb;102(1):37-43. Epub 2016 Sep 19 doi: 10.1136/archdischild-2016-311062. PMID: 27647862

Therapy

A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy.
Lafayette R, Barbour S, Israni R, Wei X, Eren N, Floege J, Jha V, Kim SG, Maes B, Phoon RKS, Singh H, Tesař V, Lin CJF, Barratt J
Kidney Int 2024 Jun;105(6):1306-1315. Epub 2024 Mar 27 doi: 10.1016/j.kint.2024.03.012. PMID: 38552841
The Effects of Febuxostat on Urine NGAL and Urine KIM-1 in Patients with Hyperuricemia.
Tang Y, Liu T, Cai Q, Zhao M
J Healthc Eng 2022;2022:6028611. Epub 2022 Apr 4 doi: 10.1155/2022/6028611. PMID: 35419185Free PMC Article
Nephrology Update: Acute Kidney Injury.
Sarabu N, Rahman M
FP Essent 2016 May;444:11-7. PMID: 27163760
Solifenacin and Tamsulosin Combination Therapy Decreases Urine Nerve Growth Factor/Creatinine Levels in Men.
Chan R, Munoz A, Wenker EP, Whipple M, Miles B, Boone TB
Urology 2016 May;91:150-3. Epub 2016 Jan 29 doi: 10.1016/j.urology.2016.01.020. PMID: 26829718
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial.
Pitt B, Kober L, Ponikowski P, Gheorghiade M, Filippatos G, Krum H, Nowack C, Kolkhof P, Kim SY, Zannad F
Eur Heart J 2013 Aug;34(31):2453-63. Epub 2013 May 27 doi: 10.1093/eurheartj/eht187. PMID: 23713082Free PMC Article

Prognosis

Subclinical AKI: ready for primetime in clinical practice?
Vanmassenhove J, Van Biesen W, Vanholder R, Lameire N
J Nephrol 2019 Feb;32(1):9-16. Epub 2018 Dec 6 doi: 10.1007/s40620-018-00566-y. PMID: 30523562
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364
Classifying AKI by Urine Output versus Serum Creatinine Level.
Kellum JA, Sileanu FE, Murugan R, Lucko N, Shaw AD, Clermont G
J Am Soc Nephrol 2015 Sep;26(9):2231-8. Epub 2015 Jan 7 doi: 10.1681/ASN.2014070724. PMID: 25568178Free PMC Article
Pseudo-(tumor-induced) rickets.
Whyte MP, Podgornik MN, Wollberg VA, Eddy MC, McAlister WH
J Bone Miner Res 2001 Aug;16(8):1564-71. doi: 10.1359/jbmr.2001.16.8.1564. PMID: 11499880

Clinical prediction guides

Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance.
Wang L, Xu X, Zhang M, Hu C, Zhang X, Li C, Nie S, Huang Z, Zhao Z, Hou FF, Zhou M
JAMA Intern Med 2023 Apr 1;183(4):298-310. doi: 10.1001/jamainternmed.2022.6817. PMID: 36804760Free PMC Article
A longitudinal study of creatine kinase and creatinine levels in Duchenne muscular dystrophy.
Zygmunt AM, Wong BL, Horn PS, Lambert J, Bange JE, Rybalsky I, Chouteau W, Tian C
Muscle Nerve 2023 Feb;67(2):138-145. Epub 2022 Dec 5 doi: 10.1002/mus.27760. PMID: 36444146
Urinary leucine aminopeptidase 3 in population environmentally exposed to airborne arsenic.
Skoczynska A, Skoczynska M, Wojakowska A, Turczyn B, Gruszczynski L, Scieszka M
Hum Exp Toxicol 2021 Aug;40(8):1308-1319. Epub 2021 Jan 27 doi: 10.1177/0960327120988874. PMID: 33501841
Subclinical AKI: ready for primetime in clinical practice?
Vanmassenhove J, Van Biesen W, Vanholder R, Lameire N
J Nephrol 2019 Feb;32(1):9-16. Epub 2018 Dec 6 doi: 10.1007/s40620-018-00566-y. PMID: 30523562
Classifying AKI by Urine Output versus Serum Creatinine Level.
Kellum JA, Sileanu FE, Murugan R, Lucko N, Shaw AD, Clermont G
J Am Soc Nephrol 2015 Sep;26(9):2231-8. Epub 2015 Jan 7 doi: 10.1681/ASN.2014070724. PMID: 25568178Free PMC Article

Recent systematic reviews

Renal Protection and Safety of Sodium-glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease.
Zhou T, Yao K, Xie Y, Lin Y, Wang J, Chen X
Curr Pharm Des 2023;29(21):1659-1670. doi: 10.2174/1381612829666230804103643. PMID: 37537933
The effect of quercetin on diabetic nephropathy (DN): a systematic review and meta-analysis of animal studies.
Hu T, Yue J, Tang Q, Cheng KW, Chen F, Peng M, Zhou Q, Wang M
Food Funct 2022 May 10;13(9):4789-4803. doi: 10.1039/d1fo03958j. PMID: 35416188
Effect of Calcium Fortified Foods on Health Outcomes: A Systematic Review and Meta-Analysis.
Cormick G, Betran AP, Romero IB, Cormick MS, Belizán JM, Bardach A, Ciapponi A
Nutrients 2021 Jan 22;13(2) doi: 10.3390/nu13020316. PMID: 33499250Free PMC Article
The Efficacy and Safety of Leflunomide for the Treatment of Lupus Nephritis in Chinese Patients: Systematic Review and Meta-Analysis.
Cao H, Rao Y, Liu L, Lin J, Yang H, Zhang X, Chen Z
PLoS One 2015;10(12):e0144548. Epub 2015 Dec 15 doi: 10.1371/journal.pone.0144548. PMID: 26670616Free PMC Article
Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis.
Mitaka C, Kudo T, Haraguchi G, Tomita M
Crit Care 2011;15(5):R258. Epub 2011 Oct 27 doi: 10.1186/cc10519. PMID: 22032777Free PMC Article

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