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Aseptic Necrosis of Bone

MedGen UID:
105445
•Concept ID:
C0520474
•
Pathologic Function
Synonyms: Bone Aseptic Necrosis; Necrosis, Aseptic, of Bone

Definition

Necrosis of bone due to an inadequate blood supply. [from NCI]

Professional guidelines

PubMed

Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen.
Wiernik PH, Dutcher JP, Paietta E, Gucalp R, Markus S, Weinberg V, Azar C, Garl S, Benson L
Leukemia 1993 Aug;7(8):1236-41. PMID: 8350624
Management of nephrotic syndrome in childhood.
Melvin T, Bennett W
Drugs 1991 Jul;42(1):30-51. doi: 10.2165/00003495-199142010-00003. PMID: 1718684
Histological differential diagnosis of aseptic bone-necrosis.
Bély M
Acta Morphol Acad Sci Hung 1979;27(1-2):95-105. PMID: 506823

Recent clinical studies

Etiology

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Prevention of glucocorticoid morbidity in giant cell arteritis.
Buttgereit F, Matteson EL, Dejaco C, Dasgupta B
Rheumatology (Oxford) 2018 Feb 1;57(suppl_2):ii11-ii21. doi: 10.1093/rheumatology/kex459. PMID: 29982779
Thrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head.
Pósán E, Szepesi K, Gáspár L, Csernátony Z, Hársfalvi J, Ajzner E, Tóth A, Udvardy M
Blood Coagul Fibrinolysis 2003 Apr;14(3):243-8. doi: 10.1097/01.mbc.0000061299.28953.34. PMID: 12695746
Clinical study of aseptic necrosis of bone after renal transplantation.
Abe H, Sako H, Okino K, Nakane Y, Kodama M, Park KI, Inoue H, Kim CJ, Tomoyoshi T
Transplant Proc 1994 Aug;26(4):1987. PMID: 8066643
Aseptic necrosis of bone in systemic lupus erythematosus. Relationship to corticosteroid therapy.
Abeles M, Urman JD, Rothfield NF
Arch Intern Med 1978 May;138(5):750-4. PMID: 646538

Diagnosis

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Gaucher disease: a comprehensive review.
Rosenbloom BE, Weinreb NJ
Crit Rev Oncog 2013;18(3):163-75. doi: 10.1615/critrevoncog.2013006060. PMID: 23510062
Aseptic necrosis and glucocorticosteroids in systemic lupus erythematosus: a reevaluation.
Weiner ES, Abeles M
J Rheumatol 1989 May;16(5):604-8. PMID: 2666654
Computer analysis of factors influencing the appearance of aseptic necrosis in patients with SLE.
Dimant J, Ginzler EM, Diamond HS, Schlesinger M, Marino CT, Weiner M, Kaplan D
J Rheumatol 1978 Summer;5(2):136-41. PMID: 671430
Septic arthritis in systemic lupus erythematosus.
Quismorio FP, Dubois EL
J Rheumatol 1975 Mar;2(1):73-82. PMID: 1185738

Therapy

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Aseptic necrosis of bone following renal transplantation: experience in 194 transplant recipients and review of the literature.
Ibels LS, Alfrey AC, Huffer WE, Weil R 3rd
Medicine (Baltimore) 1978 Jan;57(1):25-45. doi: 10.1097/00005792-197801000-00002. PMID: 337042
Aseptic necrosis of bone in adult renal transplant recipients.
Ibels LS, Alfrey AC, Huffer WE, Weil R 3rd
Proc Clin Dial Transplant Forum 1976 Nov 19-22;6:172-80. PMID: 801062
Aseptic necrosis of bone in systemic lupus erythematosus.
Leventhal GH, Dorfman HD
Semin Arthritis Rheum 1974 Fall;4(1):73-93. doi: 10.1016/0049-0172(74)90018-3. PMID: 4846262
Aseptic necrosis of bone secondary to occupational exposure to compressed air: roentgenologic findings in 59 cases.
Nellen JR, Kindwall EP
Am J Roentgenol Radium Ther Nucl Med 1972 Jul;115(3):512-24. doi: 10.2214/ajr.115.3.512. PMID: 5038632

Prognosis

Thrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head.
Pósán E, Szepesi K, Gáspár L, Csernátony Z, Hársfalvi J, Ajzner E, Tóth A, Udvardy M
Blood Coagul Fibrinolysis 2003 Apr;14(3):243-8. doi: 10.1097/01.mbc.0000061299.28953.34. PMID: 12695746
Clinical study of aseptic necrosis of bone after renal transplantation.
Abe H, Sako H, Okino K, Nakane Y, Kodama M, Park KI, Inoue H, Kim CJ, Tomoyoshi T
Transplant Proc 1994 Aug;26(4):1987. PMID: 8066643
Management of nephrotic syndrome in childhood.
Melvin T, Bennett W
Drugs 1991 Jul;42(1):30-51. doi: 10.2165/00003495-199142010-00003. PMID: 1718684
Aseptic necrosis and glucocorticosteroids in systemic lupus erythematosus: a reevaluation.
Weiner ES, Abeles M
J Rheumatol 1989 May;16(5):604-8. PMID: 2666654
Aseptic necrosis of bone; management and prognosis.
PHEMISTER DB
Postgrad Med 1948 Jul;4(1):20-5. doi: 10.1080/00325481.1948.11693653. PMID: 18874041

Clinical prediction guides

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Thrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head.
Pósán E, Szepesi K, Gáspár L, Csernátony Z, Hársfalvi J, Ajzner E, Tóth A, Udvardy M
Blood Coagul Fibrinolysis 2003 Apr;14(3):243-8. doi: 10.1097/01.mbc.0000061299.28953.34. PMID: 12695746
Dysbaric osteonecrosis: a reassessment and hypothesis.
Hutter CD
Med Hypotheses 2000 Apr;54(4):585-90. doi: 10.1054/mehy.1999.0901. PMID: 10859644
Elevated fibrin D-dimer fragment in sickle cell anemia: evidence for activation of coagulation during the steady state as well as in painful crisis.
Francis RB Jr
Haemostasis 1989;19(2):105-11. doi: 10.1159/000215901. PMID: 2731776

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