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Breast microcalcification

MedGen UID:
105455
•Concept ID:
C0520594
•
Finding
Synonyms: Microcalcification; Microcalcifications of the breast
SNOMED CT: Microcalcifications of the breast (44771000)
 
HPO: HP:0040403

Definition

The term breast microcalcification is used to define calcium deposits in the breast with a diameter of less than 1 mm. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast microcalcification

Professional guidelines

PubMed

Rapid Differential Diagnosis of Breast Microcalcification Using Targeted Near-Infrared Fluorophores.
Park MH, Lim W, Jo D, Jung JS, Kim S, Kim J, Lim HS, Lee JS, Min JJ, Hyun H
Adv Healthc Mater 2018 Apr;7(7):e1701062. Epub 2017 Dec 6 doi: 10.1002/adhm.201701062. PMID: 29210533
Clinical utility of dual-energy contrast-enhanced spectral mammography for breast microcalcifications without associated mass: a preliminary analysis.
Cheung YC, Tsai HP, Lo YF, Ueng SH, Huang PC, Chen SC
Eur Radiol 2016 Apr;26(4):1082-9. Epub 2015 Jul 10 doi: 10.1007/s00330-015-3904-z. PMID: 26159872
FDG-PET/CT detection of very early breast cancer in women with breast microcalcification lesions found in mammography screening.
Peng NJ, Chou CP, Pan HB, Chang TH, Hu C, Chiu YL, Fu TY, Chang HT
J Med Imaging Radiat Oncol 2015 Aug;59(4):445-452. Epub 2015 Apr 14 doi: 10.1111/1754-9485.12309. PMID: 25872026

Recent clinical studies

Etiology

Application value of digital tungsten-molybdenum dual target three-dimensional positioning indwelling guide wire excision biopsy in diagnosis of breast microcalcification.
Ma J
J Xray Sci Technol 2023;31(4):853-864. doi: 10.3233/XST-230039. PMID: 37248945
New insights into breast microcalcification for poor prognosis: NACT cohort and bone metastasis evaluation cohort.
Hu Y, Mao L, Wang M, Li Z, Li M, Wang C, Ji L, Zeng H, Zhang X
J Cancer Res Clin Oncol 2023 Aug;149(10):7285-7297. Epub 2023 Mar 14 doi: 10.1007/s00432-023-04668-4. PMID: 36917189
Correlation between Breast Ultrasound Microcalcification and the Prognosis of Breast Cancer.
Xue S, Zhao Q, Tai M, Li N, Liu Y
J Healthc Eng 2021;2021:6835963. Epub 2021 Nov 29 doi: 10.1155/2021/6835963. PMID: 34880978Free PMC Article
Omega-3 fatty acids in pathological calcification and bone health.
Sharma T, Mandal CC
J Food Biochem 2020 Aug;44(8):e13333. Epub 2020 Jun 17 doi: 10.1111/jfbc.13333. PMID: 32548903
A comparison of diagnostic performance of vacuum-assisted biopsy and core needle biopsy for breast microcalcification: a systematic review and meta-analysis.
Huang XC, Hu XH, Wang XR, Zhou CX, Wang FF, Yang S, Wang GY
Ir J Med Sci 2018 Nov;187(4):999-1008. Epub 2018 Mar 16 doi: 10.1007/s11845-018-1781-6. PMID: 29549564

Diagnosis

Interpretable Radiomic Signature for Breast Microcalcification Detection and Classification.
Prinzi F, Orlando A, Gaglio S, Vitabile S
J Imaging Inform Med 2024 Jun;37(3):1038-1053. Epub 2024 Feb 13 doi: 10.1007/s10278-024-01012-1. PMID: 38351223Free PMC Article
A review of ultrasound detection methods for breast microcalcification.
Ouyang YL, Zhou ZH, Wu WW, Tian J, Xu F, Wu SC, Tsui PH
Math Biosci Eng 2019 Mar 6;16(4):1761-1785. doi: 10.3934/mbe.2019085. PMID: 31137184
Breast Microcalcification Diagnosis Using Deep Convolutional Neural Network from Digital Mammograms.
Cai H, Huang Q, Rong W, Song Y, Li J, Wang J, Chen J, Li L
Comput Math Methods Med 2019;2019:2717454. Epub 2019 Mar 3 doi: 10.1155/2019/2717454. PMID: 30944574Free PMC Article
Rapid Differential Diagnosis of Breast Microcalcification Using Targeted Near-Infrared Fluorophores.
Park MH, Lim W, Jo D, Jung JS, Kim S, Kim J, Lim HS, Lee JS, Min JJ, Hyun H
Adv Healthc Mater 2018 Apr;7(7):e1701062. Epub 2017 Dec 6 doi: 10.1002/adhm.201701062. PMID: 29210533
A Molecular View of Pathological Microcalcification in Breast Cancer.
Sharma T, Radosevich JA, Pachori G, Mandal CC
J Mammary Gland Biol Neoplasia 2016 Jun;21(1-2):25-40. Epub 2016 Jan 15 doi: 10.1007/s10911-015-9349-9. PMID: 26769216

Therapy

Interpretable Radiomic Signature for Breast Microcalcification Detection and Classification.
Prinzi F, Orlando A, Gaglio S, Vitabile S
J Imaging Inform Med 2024 Jun;37(3):1038-1053. Epub 2024 Feb 13 doi: 10.1007/s10278-024-01012-1. PMID: 38351223Free PMC Article
Omega-3 fatty acids in pathological calcification and bone health.
Sharma T, Mandal CC
J Food Biochem 2020 Aug;44(8):e13333. Epub 2020 Jun 17 doi: 10.1111/jfbc.13333. PMID: 32548903
A machine learning approach on multiscale texture analysis for breast microcalcification diagnosis.
Fanizzi A, Basile TMA, Losurdo L, Bellotti R, Bottigli U, Dentamaro R, Didonna V, Fausto A, Massafra R, Moschetta M, Popescu O, Tamborra P, Tangaro S, La Forgia D
BMC Bioinformatics 2020 Mar 11;21(Suppl 2):91. doi: 10.1186/s12859-020-3358-4. PMID: 32164532Free PMC Article
Breast Tumor Microcalcification Induced by Bone Morphogenetic Protein-2: A New Murine Model for Human Breast Tumor Diagnosis.
Hajibeigi A, Nasr K, Udayakumar D, Nham K, Lenkinski RE
Contrast Media Mol Imaging 2018;2018:2082154. Epub 2018 Nov 11 doi: 10.1155/2018/2082154. PMID: 30534026Free PMC Article
Microcalcification detectability using a bench-top prototype photon-counting breast CT based on a Si strip detector.
Cho HM, Ding H, Barber WC, Iwanczyk JS, Molloi S
Med Phys 2015 Jul;42(7):4401-10. doi: 10.1118/1.4922680. PMID: 26133636Free PMC Article

Prognosis

New insights into breast microcalcification for poor prognosis: NACT cohort and bone metastasis evaluation cohort.
Hu Y, Mao L, Wang M, Li Z, Li M, Wang C, Ji L, Zeng H, Zhang X
J Cancer Res Clin Oncol 2023 Aug;149(10):7285-7297. Epub 2023 Mar 14 doi: 10.1007/s00432-023-04668-4. PMID: 36917189
Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
Correlation between Breast Ultrasound Microcalcification and the Prognosis of Breast Cancer.
Xue S, Zhao Q, Tai M, Li N, Liu Y
J Healthc Eng 2021;2021:6835963. Epub 2021 Nov 29 doi: 10.1155/2021/6835963. PMID: 34880978Free PMC Article
BMP-2 upregulates the AKT/mTOR pathway in breast cancer with microcalcification and indicates a poor prognosis.
Wang S, Gu M, Jiang H, Zheng X
Clin Transl Oncol 2020 Aug;22(8):1263-1271. Epub 2019 Dec 20 doi: 10.1007/s12094-019-02248-y. PMID: 31863351
Breast Microcalcification Diagnosis Using Deep Convolutional Neural Network from Digital Mammograms.
Cai H, Huang Q, Rong W, Song Y, Li J, Wang J, Chen J, Li L
Comput Math Methods Med 2019;2019:2717454. Epub 2019 Mar 3 doi: 10.1155/2019/2717454. PMID: 30944574Free PMC Article

Clinical prediction guides

Interpretable Radiomic Signature for Breast Microcalcification Detection and Classification.
Prinzi F, Orlando A, Gaglio S, Vitabile S
J Imaging Inform Med 2024 Jun;37(3):1038-1053. Epub 2024 Feb 13 doi: 10.1007/s10278-024-01012-1. PMID: 38351223Free PMC Article
Application value of digital tungsten-molybdenum dual target three-dimensional positioning indwelling guide wire excision biopsy in diagnosis of breast microcalcification.
Ma J
J Xray Sci Technol 2023;31(4):853-864. doi: 10.3233/XST-230039. PMID: 37248945
Adenomyoepithelioma of the Breast: A Report of 3 Cases.
AlQurashi M, Abdel Hadi M, Binammar AA, Al Muhanna A, Kussaibi H, Al Shammary E
Am J Case Rep 2022 Apr 11;23:e936070. doi: 10.12659/AJCR.936070. PMID: 35400730Free PMC Article
A convolutional deep learning model for improving mammographic breast-microcalcification diagnosis.
Kang D, Gweon HM, Eun NL, Youk JH, Kim JA, Son EJ
Sci Rep 2021 Dec 14;11(1):23925. doi: 10.1038/s41598-021-03516-0. PMID: 34907330Free PMC Article
A machine learning approach on multiscale texture analysis for breast microcalcification diagnosis.
Fanizzi A, Basile TMA, Losurdo L, Bellotti R, Bottigli U, Dentamaro R, Didonna V, Fausto A, Massafra R, Moschetta M, Popescu O, Tamborra P, Tangaro S, La Forgia D
BMC Bioinformatics 2020 Mar 11;21(Suppl 2):91. doi: 10.1186/s12859-020-3358-4. PMID: 32164532Free PMC Article

Recent systematic reviews

A comparison of diagnostic performance of vacuum-assisted biopsy and core needle biopsy for breast microcalcification: a systematic review and meta-analysis.
Huang XC, Hu XH, Wang XR, Zhou CX, Wang FF, Yang S, Wang GY
Ir J Med Sci 2018 Nov;187(4):999-1008. Epub 2018 Mar 16 doi: 10.1007/s11845-018-1781-6. PMID: 29549564

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