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Secondary Parkinson disease

MedGen UID:
10592
•Concept ID:
C0030569
•
Disease or Syndrome
Synonyms: Parkinson Disease, Secondary; Parkinson Disease, Symptomatic; Parkinsonism, Secondary; Parkinsonism, Symptomatic; Secondary Parkinson Disease; Secondary Parkinsonism; Symptomatic Parkinson Disease; Symptomatic Parkinsonism
SNOMED CT: Secondary Parkinson's disease (230292008); Secondary Parkinson disease (230292008); Secondary parkinsonism (230292008); Symptomatic parkinsonism (265377002); Disorders presenting primarily with parkinsonism (32798002)
 
Monarch Initiative: MONDO:0006966

Definition

A condition with a clinical picture similar to that of Parkinson disease, but which is caused by external factors, including medication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Parkinson disease

Professional guidelines

PubMed

Management of Pain in Parkinson's Disease.
Buhmann C, Kassubek J, Jost WH
J Parkinsons Dis 2020;10(s1):S37-S48. doi: 10.3233/JPD-202069. PMID: 32568113Free PMC Article
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS).
Lefaucheur JP, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, Cotelli M, De Ridder D, Ferrucci R, Langguth B, Marangolo P, Mylius V, Nitsche MA, Padberg F, Palm U, Poulet E, Priori A, Rossi S, Schecklmann M, Vanneste S, Ziemann U, Garcia-Larrea L, Paulus W
Clin Neurophysiol 2017 Jan;128(1):56-92. Epub 2016 Oct 29 doi: 10.1016/j.clinph.2016.10.087. PMID: 27866120
A review of nicotinamide: treatment of skin diseases and potential side effects.
Rolfe HM
J Cosmet Dermatol 2014 Dec;13(4):324-8. doi: 10.1111/jocd.12119. PMID: 25399625

Recent clinical studies

Etiology

Drug-induced parkinsonism: diagnosis and treatment.
Conn H, Jankovic J
Expert Opin Drug Saf 2024 Dec;23(12):1503-1513. Epub 2024 Oct 25 doi: 10.1080/14740338.2024.2418950. PMID: 39419777
Solvent exposure strongly linked to Parkinson's.
Wadman M
Science 2023 May 19;380(6646):683. Epub 2023 May 18 doi: 10.1126/science.adi7660. PMID: 37200442
Secondary parkinsonism.
Terashi H, Taguchi T, Aizawa H
Nihon Rinsho 2017 Jan;75(1):63-70. PMID: 30566296
Neural transplantation.
Lindvall O
Cell Transplant 1995 Jul-Aug;4(4):393-400. doi: 10.1177/096368979500400410. PMID: 7582570
Metoclopramide-induced parkinsonism.
Sethi KD, Patel B, Meador KJ
South Med J 1989 Dec;82(12):1581-2. doi: 10.1097/00007611-198912000-00033. PMID: 2595431

Diagnosis

Nonmotor Symptoms in Vascular and Other Secondary Parkinsonism.
Levin OS, Chimagomedova AS, Skripkina NA, Lyashenko EA, Babkina OV
Int Rev Neurobiol 2017;134:1303-1334. Epub 2017 Jul 4 doi: 10.1016/bs.irn.2017.05.016. PMID: 28805574
Movement disorders and stroke.
Defebvre L, Krystkowiak P
Rev Neurol (Paris) 2016 Aug-Sep;172(8-9):483-487. Epub 2016 Jul 28 doi: 10.1016/j.neurol.2016.07.006. PMID: 27476417
The diagnosis of Parkinson's disease.
Tolosa E, Wenning G, Poewe W
Lancet Neurol 2006 Jan;5(1):75-86. doi: 10.1016/S1474-4422(05)70285-4. PMID: 16361025
Parkinsonism-plus syndromes.
Jankovic J
Mov Disord 1989;4 Suppl 1:S95-119. doi: 10.1002/mds.870040512. PMID: 2657411
Symptomatic Parkinsonism.
Pearce J
Postgrad Med J 1977 Dec;53(626):726-8. doi: 10.1136/pgmj.53.626.726. PMID: 343078Free PMC Article

Therapy

Drug-induced parkinsonism: diagnosis and treatment.
Conn H, Jankovic J
Expert Opin Drug Saf 2024 Dec;23(12):1503-1513. Epub 2024 Oct 25 doi: 10.1080/14740338.2024.2418950. PMID: 39419777
Treatment of Parkinson's disease.
Italian Neurological Society; Italian Society of Clinical Neurophysiology; Guidelines for the Treatment of Parkinson's Disease 2002
Neurol Sci 2003 Jun;24 Suppl 3:S165-213. doi: 10.1007/s100720300068. PMID: 12836051
Symptomatic Parkinsonism.
Pearce J
Postgrad Med J 1977 Dec;53(626):726-8. doi: 10.1136/pgmj.53.626.726. PMID: 343078Free PMC Article
Parkinsonism--neuropathology.
Lewis PD
Br Med J 1971 Sep 18;3(5776):690-2. doi: 10.1136/bmj.3.5776.690. PMID: 4936440Free PMC Article
Drug-induced extrapyramidal syndromes.
Lader MH
J R Coll Physicians Lond 1970 Oct;5(1):87-98. PMID: 4150143Free PMC Article

Prognosis

Movement disorders and stroke.
Defebvre L, Krystkowiak P
Rev Neurol (Paris) 2016 Aug-Sep;172(8-9):483-487. Epub 2016 Jul 28 doi: 10.1016/j.neurol.2016.07.006. PMID: 27476417
The diagnosis of Parkinson's disease.
Tolosa E, Wenning G, Poewe W
Lancet Neurol 2006 Jan;5(1):75-86. doi: 10.1016/S1474-4422(05)70285-4. PMID: 16361025
Apomorphine test to predict dopaminergic responsiveness in parkinsonian syndromes.
Hughes AJ, Lees AJ, Stern GM
Lancet 1990 Jul 7;336(8706):32-4. doi: 10.1016/0140-6736(90)91531-e. PMID: 1973218
Metoclopramide-induced parkinsonism.
Sethi KD, Patel B, Meador KJ
South Med J 1989 Dec;82(12):1581-2. doi: 10.1097/00007611-198912000-00033. PMID: 2595431
Predicting Parkinson's disease.
Snyder SH, D'Amato RJ
Nature 1985 Sep 19-25;317(6034):198-9. doi: 10.1038/317198a0. PMID: 3876509

Clinical prediction guides

Drug-induced Parkinson`s disease. A clinical review.
Bohlega SA, Al-Foghom NB
Neurosciences (Riyadh) 2013 Jul;18(3):215-21. PMID: 23887211
Neural degeneration and the transport of neurotransmitters.
Edwards RH
Ann Neurol 1993 Nov;34(5):638-45. doi: 10.1002/ana.410340504. PMID: 7902065
Apomorphine test to predict dopaminergic responsiveness in parkinsonian syndromes.
Hughes AJ, Lees AJ, Stern GM
Lancet 1990 Jul 7;336(8706):32-4. doi: 10.1016/0140-6736(90)91531-e. PMID: 1973218
Predicting Parkinson's disease.
Snyder SH, D'Amato RJ
Nature 1985 Sep 19-25;317(6034):198-9. doi: 10.1038/317198a0. PMID: 3876509
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.
Langston JW, Ballard P, Tetrud JW, Irwin I
Science 1983 Feb 25;219(4587):979-80. doi: 10.1126/science.6823561. PMID: 6823561

Recent systematic reviews

Metals and neurodegenerative diseases. A systematic review.
Cicero CE, Mostile G, Vasta R, Rapisarda V, Signorelli SS, Ferrante M, Zappia M, Nicoletti A
Environ Res 2017 Nov;159:82-94. Epub 2017 Aug 1 doi: 10.1016/j.envres.2017.07.048. PMID: 28777965
Chlorpromazine versus metiapine for schizophrenia.
Zare M, Bazrafshan A
Cochrane Database Syst Rev 2017 Mar 25;3(3):CD011655. doi: 10.1002/14651858.CD011655.pub2. PMID: 28349512Free PMC Article
Parkinsonian-Pyramidal syndromes: A systematic review.
Tranchant C, Koob M, Anheim M
Parkinsonism Relat Disord 2017 Jun;39:4-16. Epub 2017 Feb 22 doi: 10.1016/j.parkreldis.2017.02.025. PMID: 28256436
Solvents and Parkinson disease: a systematic review of toxicological and epidemiological evidence.
Lock EA, Zhang J, Checkoway H
Toxicol Appl Pharmacol 2013 Feb 1;266(3):345-55. Epub 2012 Dec 7 doi: 10.1016/j.taap.2012.11.016. PMID: 23220449Free PMC Article
Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results.
van der Mark M, Brouwer M, Kromhout H, Nijssen P, Huss A, Vermeulen R
Environ Health Perspect 2012 Mar;120(3):340-7. doi: 10.1289/ehp.1103881. PMID: 22389202Free PMC Article

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