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Radicular cyst

MedGen UID:
11098
•Concept ID:
C0034543
•
Anatomical Abnormality
Synonyms: Apical Periodontal Cyst; Apical Periodontal Cysts; Cyst, Apical Periodontal; Cyst, Periapical; Cyst, Radicular; Cysts, Apical Periodontal; Cysts, Periapical; Cysts, Radicular; Periapical Cyst; Periapical Cysts; Periodontal Cyst, Apical; Periodontal Cysts, Apical; Radicular Cyst; Radicular Cysts
SNOMED CT: Radicular cyst (89988002); Apical cyst (89988002); Periapical cyst (89988002); Radiculodental cyst (89988002); Apical periodontal cyst (89988002); Periradicular cyst (89988002); Apical radicular cyst (89988002)

Definition

An odontogenic cyst of inflammatory origin associated with non-vital teeth. The maxilla is the most common site of involvement. Many radicular cysts are symptomless and discovered incidentally on radiological examination of a carious or non-vital tooth. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadicular cyst

Professional guidelines

PubMed

Assessment of Hounsfield unit in the differential diagnosis of odontogenic cysts.
Uehara K, Hisatomi M, Munhoz L, Kawazu T, Yanagi Y, Okada S, Takeshita Y, Saito EA, Asaumi J
Dentomaxillofac Radiol 2021 Feb 1;50(2):20200188. Epub 2020 Aug 12 doi: 10.1259/dmfr.20200188. PMID: 32783633Free PMC Article
Management of Large Radicular Lesions Using Decompression: A Case Series and Review of the Literature.
Tian FC, Bergeron BE, Kalathingal S, Morris M, Wang XY, Niu LN, Tay FR
J Endod 2019 May;45(5):651-659. Epub 2019 Mar 2 doi: 10.1016/j.joen.2018.12.014. PMID: 30833094
The treatment of the apical granuloma and the small radicular cyst.
BLUM T
N Y State Dent J 1947 Dec;13(10):576-9. PMID: 20270902

Recent clinical studies

Etiology

Prevalence of Nonendodontic Diagnoses in Periapical Biopsies: A 6-year Institutional Experience.
Rudman J, He J, Jalali P, Khalighinejad N, Woo V
J Endod 2022 Oct;48(10):1257-1262. Epub 2022 Jul 14 doi: 10.1016/j.joen.2022.07.003. PMID: 35843357
Endoscopic enucleation of large jaw cysts: Promising outcomes.
Abdelwahab M, Elfattah AMA, Khafagy YW, El-Degwi A
Auris Nasus Larynx 2018 Jun;45(3):578-584. Epub 2017 Sep 24 doi: 10.1016/j.anl.2017.08.008. PMID: 28951046
Odontogenic cysts. A clinicopathological study.
Al Sheddi MA
Saudi Med J 2012 Mar;33(3):304-8. PMID: 22426912
Huge radicular cyst.
Lee JY, Byun JY
Otolaryngol Head Neck Surg 2010 Nov;143(5):704-5. Epub 2010 Aug 16 doi: 10.1016/j.otohns.2010.06.816. PMID: 20974345
Periapical surgery.
Hirsch JM, Ahlström U, Henrikson PA, Heyden G, Peterson LE
Int J Oral Surg 1979 Jun;8(3):173-85. doi: 10.1016/s0300-9785(79)80016-2. PMID: 118123

Diagnosis

The Paradigm of the Inflammatory Radicular Cyst: Biological Aspects to be Considered.
Rios Osorio N, Caviedes-Bucheli J, Mosquera-Guevara L, Adames-Martinez JS, Gomez-Pinto D, Jimenez-Jimenez K, Avendano Maz H, Bornacelly-Mendoza S
Eur Endod J 2023 Jan;8(1):20-36. doi: 10.14744/eej.2022.26918. PMID: 36748442Free PMC Article
Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133
Giant radicular cyst of the maxilla.
Deshmukh J, Shrivastava R, Bharath KP, Mallikarjuna R
BMJ Case Rep 2014 May 2;2014 doi: 10.1136/bcr-2014-203678. PMID: 24792022Free PMC Article
Huge radicular cyst.
Lee JY, Byun JY
Otolaryngol Head Neck Surg 2010 Nov;143(5):704-5. Epub 2010 Aug 16 doi: 10.1016/j.otohns.2010.06.816. PMID: 20974345
Sinusitis of dental origin.
Bertrand B, Rombaux P, Eloy P, Reychler H
Acta Otorhinolaryngol Belg 1997;51(4):315-22. PMID: 9444378

Therapy

On the causes of persistent apical periodontitis: a review.
Nair PN
Int Endod J 2006 Apr;39(4):249-81. doi: 10.1111/j.1365-2591.2006.01099.x. PMID: 16584489
Root perforation repair: surgical and nonsurgical management.
Roda RS
Pract Proced Aesthet Dent 2001 Aug;13(6):467-72; quiz 474. PMID: 11544819
Periradicular curettage.
Lin LM, Gaengler P, Langeland K
Int Endod J 1996 Jul;29(4):220-7. doi: 10.1111/j.1365-2591.1996.tb01373.x. PMID: 9206437
Biological perspectives on the non-surgical endodontic management of periradicular pathosis.
Maalouf EM, Gutmann JL
Int Endod J 1994 May;27(3):154-62. doi: 10.1111/j.1365-2591.1994.tb00246.x. PMID: 7995649
Immunologic aspects of pulpal-periapical diseases. A review.
Morse DR
Oral Surg Oral Med Oral Pathol 1977 Mar;43(3):436-51. doi: 10.1016/0030-4220(77)90331-0. PMID: 320531

Prognosis

The Dilemma Of Management Of Cystic Lesions; An Uncertain Way Forward: A Case Report.
Umer F, Adnan N, Khan M, Qureshi MB
J Pak Med Assoc 2023 Nov;73(11):2269-2272. doi: 10.47391/JPMA.8601. PMID: 38013545
Endoscopic enucleation of large jaw cysts: Promising outcomes.
Abdelwahab M, Elfattah AMA, Khafagy YW, El-Degwi A
Auris Nasus Larynx 2018 Jun;45(3):578-584. Epub 2017 Sep 24 doi: 10.1016/j.anl.2017.08.008. PMID: 28951046
Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133
Huge radicular cyst.
Lee JY, Byun JY
Otolaryngol Head Neck Surg 2010 Nov;143(5):704-5. Epub 2010 Aug 16 doi: 10.1016/j.otohns.2010.06.816. PMID: 20974345
Periapical surgery.
Hirsch JM, Ahlström U, Henrikson PA, Heyden G, Peterson LE
Int J Oral Surg 1979 Jun;8(3):173-85. doi: 10.1016/s0300-9785(79)80016-2. PMID: 118123

Clinical prediction guides

Nlrp3 inflammasome drives regulatory T cell depletion to accelerate periapical bone erosion.
Wang K, Liu J, Yue J, Zhou L, Mao H, Li J, Sun Z, Chen Z, Zhang L
Int Endod J 2024 Aug;57(8):1110-1123. Epub 2024 Mar 5 doi: 10.1111/iej.14062. PMID: 38441141
Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
Liang ZZ, Li J, Huang SG
Genet Mol Res 2017 Mar 30;16(1) doi: 10.4238/gmr16019329. PMID: 28362997
Histopathological study of radicular cysts diagnosed in a Brazilian population.
Santos LC, Vilas Bôas DS, Oliveira GQ, Ramos EA, Gurgel CA, dos Santos JN
Braz Dent J 2011;22(6):449-54. doi: 10.1590/s0103-64402011000600002. PMID: 22189638
Biofilms and apical periodontitis: study of prevalence and association with clinical and histopathologic findings.
Ricucci D, Siqueira JF Jr
J Endod 2010 Aug;36(8):1277-88. Epub 2010 Jun 14 doi: 10.1016/j.joen.2010.04.007. PMID: 20647081
Proliferative activity in periapical lesions.
Tripi TR, Bonaccorso A, Rapisarda E, Bartoloni G
Aust Endod J 2003 Apr;29(1):31-3. doi: 10.1111/j.1747-4477.2003.tb00494.x. PMID: 12772970

Recent systematic reviews

Treatment options of periapical cysts of deciduous teeth: report of a case and systematic review of the literature.
Izzetti R, Giuca MR, Lardani L, Nisi M, Carli E
Eur J Paediatr Dent 2024 Jun 3;25(2):113-119. Epub 2024 Mar 1 doi: 10.23804/ejpd.2024.1993. PMID: 38533834
A novel histopathological classification of implant periapical lesion: A systematic review and treatment decision tree.
Gong J, Zhao R, Yu Z, Li J, Mei M
PLoS One 2022;17(12):e0277387. Epub 2022 Dec 22 doi: 10.1371/journal.pone.0277387. PMID: 36548276Free PMC Article
Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis.
Garg RK, O'Connor MK, Sterling DA, Jacob L, Hammoudeh JA, Andrews BT
J Craniofac Surg 2022 May 1;33(3):870-874. Epub 2021 Sep 23 doi: 10.1097/SCS.0000000000008201. PMID: 34560739
Prevalence of odontogenic cysts and tumors associated with impacted third molars: A systematic review and meta-analysis.
Mello FW, Melo G, Kammer PV, Speight PM, Rivero ERC
J Craniomaxillofac Surg 2019 Jun;47(6):996-1002. Epub 2019 Mar 30 doi: 10.1016/j.jcms.2019.03.026. PMID: 31005378
Frequency of odontogenic cysts and tumors: a systematic review.
Johnson NR, Gannon OM, Savage NW, Batstone MD
J Investig Clin Dent 2014 Feb;5(1):9-14. Epub 2013 Jun 14 doi: 10.1111/jicd.12044. PMID: 23766099

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