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Hemorrhagic shock

MedGen UID:
11409
•Concept ID:
C0036982
•
Pathologic Function
Synonyms: Hemorrhagic Shock; Shock, Hemorrhagic
SNOMED CT: Hemorrhagic shock (355001)

Definition

Hypoperfusion of body tissues due to acute blood loss, resulting in cellular injury and vital organ dysfunction. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhagic shock

Professional guidelines

PubMed

Pediatric traumatic hemorrhagic shock consensus conference recommendations.
Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC
J Trauma Acute Care Surg 2023 Jan 1;94(1S Suppl 1):S2-S10. Epub 2022 Oct 17 doi: 10.1097/TA.0000000000003805. PMID: 36245074Free PMC Article
Guideline No. 431: Postpartum Hemorrhage and Hemorrhagic Shock.
Robinson D, Basso M, Chan C, Duckitt K, Lett R
J Obstet Gynaecol Can 2022 Dec;44(12):1293-1310.e1. doi: 10.1016/j.jogc.2022.10.002. PMID: 36567097
Evaluation and Treatment of Massive Hemoptysis.
Prey B, Francis A, Williams J, Krishnadasan B
Surg Clin North Am 2022 Jun;102(3):465-481. doi: 10.1016/j.suc.2021.11.002. PMID: 35671767

Recent clinical studies

Etiology

Norepinephrine and Vasopressin in Hemorrhagic Shock: A Focus on Renal Hemodynamics.
Fage N, Asfar P, Radermacher P, Demiselle J
Int J Mol Sci 2023 Feb 17;24(4) doi: 10.3390/ijms24044103. PMID: 36835514Free PMC Article
Trauma-induced hypocalcemia.
DeBot M, Sauaia A, Schaid T, Moore EE
Transfusion 2022 Aug;62 Suppl 1:S274-S280. Epub 2022 Jun 24 doi: 10.1111/trf.16959. PMID: 35748689
Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial.
Sims CA, Holena D, Kim P, Pascual J, Smith B, Martin N, Seamon M, Shiroff A, Raza S, Kaplan L, Grill E, Zimmerman N, Mason C, Abella B, Reilly P
JAMA Surg 2019 Nov 1;154(11):994-1003. doi: 10.1001/jamasurg.2019.2884. PMID: 31461138Free PMC Article
Hemorrhagic Shock and the Microvasculature.
Torres Filho I
Compr Physiol 2017 Dec 12;8(1):61-101. doi: 10.1002/cphy.c170006. PMID: 29357125
Complications of massive transfusion.
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407

Diagnosis

Management of Pelvic Trauma.
Baker JE, Werner NL, Burlew CC
Surg Clin North Am 2024 Apr;104(2):367-384. Epub 2023 Nov 22 doi: 10.1016/j.suc.2023.10.001. PMID: 38453308
Bleeding, Hemorrhagic Shock, and the Global Blood Supply.
Faria I, Thivalapill N, Makin J, Puyana JC, Raykar N
Crit Care Clin 2022 Oct;38(4):775-793. doi: 10.1016/j.ccc.2022.06.013. PMID: 36162910
Evaluation and Treatment of Massive Hemoptysis.
Prey B, Francis A, Williams J, Krishnadasan B
Surg Clin North Am 2022 Jun;102(3):465-481. doi: 10.1016/j.suc.2021.11.002. PMID: 35671767
Hemorrhagic Shock.
Cannon JW
N Engl J Med 2018 Jan 25;378(4):370-379. doi: 10.1056/NEJMra1705649. PMID: 29365303
Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
Chang R, Holcomb JB
Crit Care Clin 2017 Jan;33(1):15-36. doi: 10.1016/j.ccc.2016.08.007. PMID: 27894494Free PMC Article

Therapy

Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial.
Sims CA, Holena D, Kim P, Pascual J, Smith B, Martin N, Seamon M, Shiroff A, Raza S, Kaplan L, Grill E, Zimmerman N, Mason C, Abella B, Reilly P
JAMA Surg 2019 Nov 1;154(11):994-1003. doi: 10.1001/jamasurg.2019.2884. PMID: 31461138Free PMC Article
Resuscitation for Hypovolemic Shock.
Kalkwarf KJ, Cotton BA
Surg Clin North Am 2017 Dec;97(6):1307-1321. doi: 10.1016/j.suc.2017.07.011. PMID: 29132511
Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
Chang R, Holcomb JB
Crit Care Clin 2017 Jan;33(1):15-36. doi: 10.1016/j.ccc.2016.08.007. PMID: 27894494Free PMC Article
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Vasoactive drugs in circulatory shock.
Hollenberg SM
Am J Respir Crit Care Med 2011 Apr 1;183(7):847-55. Epub 2010 Nov 19 doi: 10.1164/rccm.201006-0972CI. PMID: 21097695

Prognosis

Risk Factors for Neonatal/Maternal Morbidity and Mortality in African American Women with Placental Abruption.
Elkafrawi D, Sisti G, Araji S, Khoury A, Miller J, Rodriguez Echevarria B
Medicina (Kaunas) 2020 Apr 13;56(4) doi: 10.3390/medicina56040174. PMID: 32295061Free PMC Article
Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.
Pusateri AE, Moore EE, Moore HB, Le TD, Guyette FX, Chapman MP, Sauaia A, Ghasabyan A, Chandler J, McVaney K, Brown JB, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Sperry JL
JAMA Surg 2020 Feb 1;155(2):e195085. Epub 2020 Feb 19 doi: 10.1001/jamasurg.2019.5085. PMID: 31851290Free PMC Article
Acute kidney injury in trauma patients.
Harrois A, Libert N, Duranteau J
Curr Opin Crit Care 2017 Dec;23(6):447-456. doi: 10.1097/MCC.0000000000000463. PMID: 29035925
Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study.
Morrison JJ, Dubose JJ, Rasmussen TE, Midwinter MJ
Arch Surg 2012 Feb;147(2):113-9. Epub 2011 Oct 17 doi: 10.1001/archsurg.2011.287. PMID: 22006852
Complications of massive transfusion.
Sihler KC, Napolitano LM
Chest 2010 Jan;137(1):209-20. doi: 10.1378/chest.09-0252. PMID: 20051407

Clinical prediction guides

Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock.
Cralley AL, Vigneshwar N, Moore EE, Dubose J, Brenner ML, Sauaia A; AAST AORTA Study Group
JAMA Surg 2023 Feb 1;158(2):140-150. doi: 10.1001/jamasurg.2022.6393. PMID: 36542395Free PMC Article
Impact of Incorporating Whole Blood into Hemorrhagic Shock Resuscitation: Analysis of 1,377 Consecutive Trauma Patients Receiving Emergency-Release Uncrossmatched Blood Products.
Brill JB, Tang B, Hatton G, Mueck KM, McCoy CC, Kao LS, Cotton BA
J Am Coll Surg 2022 Apr 1;234(4):408-418. doi: 10.1097/XCS.0000000000000086. PMID: 35290259
Prediction of Massive Transfusion in Trauma.
Cantle PM, Cotton BA
Crit Care Clin 2017 Jan;33(1):71-84. doi: 10.1016/j.ccc.2016.08.002. PMID: 27894500
Optimal Fluid Therapy for Traumatic Hemorrhagic Shock.
Chang R, Holcomb JB
Crit Care Clin 2017 Jan;33(1):15-36. doi: 10.1016/j.ccc.2016.08.007. PMID: 27894494Free PMC Article
Hypoalbuminemia.
Gatta A, Verardo A, Bolognesi M
Intern Emerg Med 2012 Oct;7 Suppl 3:S193-9. doi: 10.1007/s11739-012-0802-0. PMID: 23073857

Recent systematic reviews

Resuscitative endovascular balloon occlusion of the aorta (REBOA) in patients with major trauma and uncontrolled haemorrhagic shock: a systematic review with meta-analysis.
Castellini G, Gianola S, Biffi A, Porcu G, Fabbri A, Ruggieri MP, Coniglio C, Napoletano A, Coclite D, D'Angelo D, Fauci AJ, Iacorossi L, Latina R, Salomone K, Gupta S, Iannone P, Chiara O; Italian National Institute of Health guideline working group on Major Trauma
World J Emerg Surg 2021 Aug 12;16(1):41. doi: 10.1186/s13017-021-00386-9. PMID: 34384452Free PMC Article
Permissive hypotension versus conventional resuscitation strategies in adult trauma patients with hemorrhagic shock: A systematic review and meta-analysis of randomized controlled trials.
Tran A, Yates J, Lau A, Lampron J, Matar M
J Trauma Acute Care Surg 2018 May;84(5):802-808. doi: 10.1097/TA.0000000000001816. PMID: 29370058
A Systematic Review of Neuroprotective Strategies during Hypovolemia and Hemorrhagic Shock.
Nistor M, Behringer W, Schmidt M, Schiffner R
Int J Mol Sci 2017 Oct 26;18(11) doi: 10.3390/ijms18112247. PMID: 29072635Free PMC Article
Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials.
Cossu AP, Mura P, De Giudici LM, Puddu D, Pasin L, Evangelista M, Xanthos T, Musu M, Finco G
Biomed Res Int 2014;2014:421291. Epub 2014 Sep 1 doi: 10.1155/2014/421291. PMID: 25254206Free PMC Article
Corticosteroids for dengue infection.
Zhang F, Kramer CV
Cochrane Database Syst Rev 2014 Jul 1;2014(7):CD003488. doi: 10.1002/14651858.CD003488.pub3. PMID: 24984082Free PMC Article

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