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Thyroglossal cyst

MedGen UID:
11810
•Concept ID:
C0040124
•
Congenital Abnormality
Synonym: Thyroglossal duct cyst
SNOMED CT: Thyroglossal duct cyst (39462005); Thyroglossal cyst (39462005)
 
HPO: HP:0010518
Monarch Initiative: MONDO:0006460
Orphanet: ORPHA489

Definition

An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroglossal cyst

Professional guidelines

PubMed

Ethanol ablation for the treatment of thyroglossal duct cysts: follow-up results for longer than 2 years.
Park SI, Baek JH, Chung SR, Choi YJ, Lee JH, Kim TY, Lee YM, Baek SM
Eur Radiol 2022 May;32(5):3525-3531. Epub 2022 Jan 7 doi: 10.1007/s00330-021-08402-x. PMID: 34993573
Chemical ablation using ethanol or OK-432 for the treatment of thyroglossal duct cysts: a systematic review and meta-analysis.
Park SI, Baek JH, Suh CH, Chung SR, Choi YJ, Kim TY, Lee YM, Lee JH
Eur Radiol 2021 Dec;31(12):9048-9056. Epub 2021 May 18 doi: 10.1007/s00330-021-08033-2. PMID: 34003346
Management of well-differentiated thyroid carcinoma presenting within a thyroglossal duct cyst.
Patel SG, Escrig M, Shaha AR, Singh B, Shah JP
J Surg Oncol 2002 Mar;79(3):134-9; discussion 140-1. doi: 10.1002/jso.10059. PMID: 11870661

Recent clinical studies

Etiology

¿Who was Sistrunk?
Girón Vallejo O
Cir Pediatr 2022 Apr 1;35(2):55-56. doi: 10.54847/cp.2022.02.11. PMID: 35485751
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Midline cervical swellings: What a paediatrician needs to know.
Nightingale M
J Paediatr Child Health 2017 Nov;53(11):1086-1090. doi: 10.1111/jpc.13759. PMID: 29148189
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555
Thyroglossal duct carcinoma.
Joseph TJ, Komorowski RA
Hum Pathol 1975 Nov;6(6):717-29. doi: 10.1016/s0046-8177(75)80080-3. PMID: 1102426

Diagnosis

Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Thyroglossal duct cyst.
Thompson LD
Ear Nose Throat J 2017 Feb;96(2):54-55. doi: 10.1177/014556131709600204. PMID: 28231361
Curiositas.
Ulster Med J 2015 Oct;84(3):215-6. PMID: 26668426Free PMC Article
Pediatric neck masses.
Curtis WJ, Edwards SP
Atlas Oral Maxillofac Surg Clin North Am 2015 Mar;23(1):15-20. Epub 2014 Nov 26 doi: 10.1016/j.cxom.2014.10.002. PMID: 25707561
Pediatric neck masses.
Goins MR, Beasley MS
Oral Maxillofac Surg Clin North Am 2012 Aug;24(3):457-68. doi: 10.1016/j.coms.2012.05.006. PMID: 22857718

Therapy

Acute Neck Swelling in a Child.
Veeraraghavan N, Bharwani H, Habib H
Am Fam Physician 2021 Apr 1;103(7):437-438. PMID: 33788515
Postoperative Disposition Following Pediatric Sistrunk Procedures: A National Database Query.
Brooks JA, Cunningham MJ, Hughes AL, Kawai K, Dombrowski ND, Adil E
Laryngoscope 2021 Jul;131(7):E2352-E2355. Epub 2021 Jan 11 doi: 10.1002/lary.29331. PMID: 33427321
Curiositas.
Ulster Med J 2015 Oct;84(3):215-6. PMID: 26668426Free PMC Article
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555
Thyroglossal duct carcinoma in children: case presentation and review of the literature.
Peretz A, Leiberman E, Kapelushnik J, Hershkovitz E
Thyroid 2004 Sep;14(9):777-85. doi: 10.1089/thy.2004.14.777. PMID: 15361266

Prognosis

Congenital Neck Masses.
Ryu J, Igawa T, Mohole J, Coward M
Neoreviews 2023 Oct 1;24(10):e642-e649. doi: 10.1542/neo.24-10-e642. PMID: 37777610
Congenital Neck Masses.
Quintanilla-Dieck L, Penn EB Jr
Clin Perinatol 2018 Dec;45(4):769-785. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.012. PMID: 30396417
Branchial cleft anomalies and thymic cysts.
Prosser JD, Myer CM 3rd
Otolaryngol Clin North Am 2015 Feb;48(1):1-14. doi: 10.1016/j.otc.2014.09.002. PMID: 25442127
Congenital lesions of epithelial origin.
Hills SE, Maddalozzo J
Otolaryngol Clin North Am 2015 Feb;48(1):209-23. doi: 10.1016/j.otc.2014.09.014. PMID: 25439555
Management of congenital anomalies of the neck.
Enepekides DJ
Facial Plast Surg Clin North Am 2001 Feb;9(1):131-45. PMID: 11465000

Clinical prediction guides

Uncommon Insidious Dumbbell-shaped Double Thyroglossal Duct Cyst.
Guo Y, Huang Q, Chen H, Xu C
J Craniofac Surg 2023 Mar-Apr 01;34(2):e122-e124. Epub 2022 Aug 1 doi: 10.1097/SCS.0000000000008844. PMID: 36857559Free PMC Article
Postoperative Disposition Following Pediatric Sistrunk Procedures: A National Database Query.
Brooks JA, Cunningham MJ, Hughes AL, Kawai K, Dombrowski ND, Adil E
Laryngoscope 2021 Jul;131(7):E2352-E2355. Epub 2021 Jan 11 doi: 10.1002/lary.29331. PMID: 33427321
Tracheal injury complicating Sistrunk's thyroglossal cyst surgery.
Blanc F, Blanchet C, Mondain M, Akkari M
Eur Ann Otorhinolaryngol Head Neck Dis 2020 Mar;137(2):131-133. Epub 2019 Oct 22 doi: 10.1016/j.anorl.2019.10.005. PMID: 31653460
CT and MRI findings of developmental abnormalities and ectopia varieties of the thyroid gland.
Altay C, Erdoğan N, Karasu S, Uluç E, Sarsılmaz A, Mete B, Oyar O
Diagn Interv Radiol 2012 Jul-Aug;18(4):335-43. Epub 2012 Feb 13 doi: 10.4261/1305-3825.DIR.4913-11.2. PMID: 22328282
Thyroglossal duct cysts and branchial cleft anomalies.
Roback SA, Telander RL
Semin Pediatr Surg 1994 Aug;3(3):142-6. PMID: 7987629

Recent systematic reviews

Endoscopic management of intralingual thyroglossal duct cysts: Case series and systematic review.
Pereira NM, Drusin MA, Modi VK
Auris Nasus Larynx 2023 Feb;50(1):119-125. Epub 2022 Jun 2 doi: 10.1016/j.anl.2022.05.014. PMID: 35659788
Chemical ablation using ethanol or OK-432 for the treatment of thyroglossal duct cysts: a systematic review and meta-analysis.
Park SI, Baek JH, Suh CH, Chung SR, Choi YJ, Kim TY, Lee YM, Lee JH
Eur Radiol 2021 Dec;31(12):9048-9056. Epub 2021 May 18 doi: 10.1007/s00330-021-08033-2. PMID: 34003346
Thyroglossal Duct Cyst Carcinoma: A Systematic Review of Clinical Features and Outcomes.
Rayess HM, Monk I, Svider PF, Gupta A, Raza SN, Lin HS
Otolaryngol Head Neck Surg 2017 May;156(5):794-802. Epub 2017 Mar 21 doi: 10.1177/0194599817696504. PMID: 28322121
Surgical management outcomes of recurrent thyroglossal duct cyst in children--A systematic review.
Ibrahim FF, Alnoury MK, Varma N, Daniel SJ
Int J Pediatr Otorhinolaryngol 2015 Jun;79(6):863-867. Epub 2015 Mar 28 doi: 10.1016/j.ijporl.2015.03.019. PMID: 25890397
Risk of recurrence in children operated for thyroglossal duct cysts: A systematic review.
Galluzzi F, Pignataro L, Gaini RM, Hartley B, Garavello W
J Pediatr Surg 2013 Jan;48(1):222-7. doi: 10.1016/j.jpedsurg.2012.10.060. PMID: 23331819

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