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Hemophilic arthropathy

MedGen UID:
120487
•Concept ID:
C0263725
•
Disease or Syndrome
Synonyms: arthropathy in haemophilia; Arthropathy in hemophilia; arthropathy in hemophilia; Hemophilic arthritis; Hemophilic Arthritis; hemophilic arthritis; hemophilic arthropathy
SNOMED CT: Arthropathy in hemophilia (80813006); Hemophilic arthritis (80813006); Hemophilic arthropathy (80813006)
 
Monarch Initiative: MONDO:0043240

Definition

A form of arthritis that affects hemophiliacs, which is characterized by bleeding into the joint space. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemophilic arthropathy

Professional guidelines

PubMed

Management of Hemophilic Arthropathy of the Ankle.
Rodriguez-Merchan EC
Cardiovasc Hematol Disord Drug Targets 2017;17(2):111-118. doi: 10.2174/1871529X17666170908110758. PMID: 28891453
Nonsurgical management of hemophilic arthropathy.
Greene WB, McMillan CW
Instr Course Lect 1989;38:367-81. PMID: 2649587
Hemophilic arthropathy. Current concepts of pathogenesis and management.
Arnold WD, Hilgartner MW
J Bone Joint Surg Am 1977 Apr;59(3):287-305. PMID: 849938

Recent clinical studies

Etiology

Hemophilic arthropathy: Current knowledge and future perspectives.
Gualtierotti R, Solimeno LP, Peyvandi F
J Thromb Haemost 2021 Sep;19(9):2112-2121. Epub 2021 Jul 27 doi: 10.1111/jth.15444. PMID: 34197690Free PMC Article
Inhibitors in Hemophilia B.
Santoro C, Quintavalle G, Castaman G, Baldacci E, Ferretti A, Riccardi F, Tagliaferri A
Semin Thromb Hemost 2018 Sep;44(6):578-589. Epub 2018 Jun 20 doi: 10.1055/s-0038-1660817. PMID: 29925096
Current role for radioisotope synovectomy.
André V, Dalibard V, Dernis E, Varin S, Cormier G
Joint Bone Spine 2018 May;85(3):295-299. Epub 2017 Jun 23 doi: 10.1016/j.jbspin.2017.06.002. PMID: 28652100
Total joint replacement in patients with inhibitors.
Solimeno LP, Perfetto OS, Pasta G, Santagostino E
Haemophilia 2006 Jul;12 Suppl 3:113-6. doi: 10.1111/j.1365-2516.2006.01267.x. PMID: 16684005
Bacterial arthritis.
Ho G Jr
Curr Opin Rheumatol 1992 Aug;4(4):509-15. PMID: 1503874

Diagnosis

Soft Tissue Pathology.
Shane AM, Reeves CL, Nguyen GB, Ferrise TD, Calaj PM
Clin Podiatr Med Surg 2023 Jul;40(3):381-395. Epub 2023 Apr 28 doi: 10.1016/j.cpm.2023.02.003. PMID: 37236677
Hemophilic arthropathy: Current knowledge and future perspectives.
Gualtierotti R, Solimeno LP, Peyvandi F
J Thromb Haemost 2021 Sep;19(9):2112-2121. Epub 2021 Jul 27 doi: 10.1111/jth.15444. PMID: 34197690Free PMC Article
Hemophilic Arthropathy.
Nacca CR, Harris AP, Tuttle JR
Orthopedics 2017 Nov 1;40(6):e940-e946. Epub 2017 Jun 30 doi: 10.3928/01477447-20170619-05. PMID: 28662249
Hemophilic arthropathy: a review of imaging and staging.
Cross S, Vaidya S, Fotiadis N
Semin Ultrasound CT MR 2013 Dec;34(6):516-24. doi: 10.1053/j.sult.2013.05.007. PMID: 24332203
Hemophilic arthropathy.
Lan HH, Eustace SJ, Dorfman D
Radiol Clin North Am 1996 Mar;34(2):446-50. PMID: 8633126

Therapy

Hemostatic cover in orthopedic surgery.
Álvarez Román MT
Blood Coagul Fibrinolysis 2023 Jun 1;34(S1):S22-S25. doi: 10.1097/MBC.0000000000001201. PMID: 37254727
Inhibitors in Hemophilia B.
Santoro C, Quintavalle G, Castaman G, Baldacci E, Ferretti A, Riccardi F, Tagliaferri A
Semin Thromb Hemost 2018 Sep;44(6):578-589. Epub 2018 Jun 20 doi: 10.1055/s-0038-1660817. PMID: 29925096
Hemophilic arthropathy.
Luck JV Jr, Silva M, Rodriguez-Merchan EC, Ghalambor N, Zahiri CA, Finn RS
J Am Acad Orthop Surg 2004 Jul-Aug;12(4):234-45. doi: 10.5435/00124635-200407000-00004. PMID: 15473675
Hemophilic arthropathy. Current concepts of pathogenesis and management.
Arnold WD, Hilgartner MW
J Bone Joint Surg Am 1977 Apr;59(3):287-305. PMID: 849938
Hemophilic arthropathy.
Hilgartner MW
Adv Pediatr 1974;21:139-65. PMID: 4614656

Prognosis

Cytokines in the pathogenesis of hemophilic arthropathy.
Wojdasiewicz P, Poniatowski ŁA, Nauman P, Mandat T, Paradowska-Gorycka A, Romanowska-Próchnicka K, Szukiewicz D, Kotela A, Kubaszewski Ł, Kotela I, Kurkowska-Jastrzębska I, Gasik R
Cytokine Growth Factor Rev 2018 Feb;39:71-91. Epub 2017 Nov 13 doi: 10.1016/j.cytogfr.2017.11.003. PMID: 29153709
Current role for radioisotope synovectomy.
André V, Dalibard V, Dernis E, Varin S, Cormier G
Joint Bone Spine 2018 May;85(3):295-299. Epub 2017 Jun 23 doi: 10.1016/j.jbspin.2017.06.002. PMID: 28652100
Pathophysiology of hemophilic arthropathy and potential targets for therapy.
Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP, van Vulpen LF
Pharmacol Res 2017 Jan;115:192-199. Epub 2016 Nov 24 doi: 10.1016/j.phrs.2016.11.032. PMID: 27890816
Advances and challenges in hemophilic arthropathy.
Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902Free PMC Article
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

Clinical prediction guides

Pathophysiology of hemophilic arthropathy and potential targets for therapy.
Pulles AE, Mastbergen SC, Schutgens RE, Lafeber FP, van Vulpen LF
Pharmacol Res 2017 Jan;115:192-199. Epub 2016 Nov 24 doi: 10.1016/j.phrs.2016.11.032. PMID: 27890816
Advances and challenges in hemophilic arthropathy.
Wyseure T, Mosnier LO, von Drygalski A
Semin Hematol 2016 Jan;53(1):10-9. Epub 2015 Oct 26 doi: 10.1053/j.seminhematol.2015.10.005. PMID: 26805902Free PMC Article
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216
Hemophilic arthropathy: a review of imaging and staging.
Cross S, Vaidya S, Fotiadis N
Semin Ultrasound CT MR 2013 Dec;34(6):516-24. doi: 10.1053/j.sult.2013.05.007. PMID: 24332203
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy.
Lobet S, Hermans C, Bastien GJ, Massaad F, Detrembleur C
Clin Biomech (Bristol) 2012 Jul;27(6):625-31. Epub 2012 Feb 29 doi: 10.1016/j.clinbiomech.2012.01.009. PMID: 22381586

Recent systematic reviews

Pathogenesis of osteoarthritis, rheumatoid arthritis, and hemophilic arthropathy: The role of angiogenesis.
Caliogna L, Berni M, Torriani C, Mancuso ME, Di Minno MND, Brancato AM, Jannelli E, Mosconi M, Pasta G
Haemophilia 2024 Nov;30(6):1256-1264. Epub 2024 Sep 19 doi: 10.1111/hae.15097. PMID: 39297375Free PMC Article
Efficacy of rehabilitation interventions on functioning in patients with hemophilic arthropathy: A systematic review with meta-analysis.
Lippi L, de Sire A, Turco A, Santi RM, Polverelli M, Ammendolia A, Follenzi A, Invernizzi M
J Back Musculoskelet Rehabil 2024;37(4):853-870. doi: 10.3233/BMR-230320. PMID: 38578880
Total Knee Arthroplasty in Hemophilia: Survivorship and Outcomes-A Systematic Review and Meta-Analysis.
Fenelon C, Murphy EP, Fahey EJ, Murphy RP, O'Connell NM, Queally JM
J Arthroplasty 2022 Mar;37(3):581-592.e1. Epub 2021 Oct 28 doi: 10.1016/j.arth.2021.10.015. PMID: 34756977
Biochemical marker research in hemophilic arthropathy: A systematic review.
van Bergen EDP, van Vulpen LFD, Schutgens REG, Mastbergen SC, Lafeber FPJG
Blood Rev 2021 May;47:100781. Epub 2020 Nov 22 doi: 10.1016/j.blre.2020.100781. PMID: 33277057
Synovium and cartilage biomarkers in hemophilic arthropathy.
Rodriguez-Merchan EC
Expert Rev Hematol 2016;9(4):409-14. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1141674. PMID: 26761216

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